Integrated bulk RNA-seq and scRNA-seq identification of a novel "PET- SPI1- MYL9" transcriptional axis in lung adenocarcinoma driven by polyethylene terephthalate exposure [0.03%]
结合bulk RNA-seq和scRNA-seq鉴定出的新型“PET-SPI1-MYL9”转录轴在聚对苯二甲酸乙二醇酯暴露驱动的肺腺癌中的作用
Qian Su,Juanjuan Guo,Yilin Gu et al.
Qian Su et al.
Background: Airborne microplastic polyethylene terephthalate (PET) accumulates in human lungs and is linked to respiratory pathologies; however, its molecular role in lung adenocarcinoma (LUAD) remains unclear. This study...
Short-term response to alectinib and rapid progression in a lung squamous cell carcinoma patient harboring an EML4-ALK fusion: a case report [0.03%]
阿来替尼对携带EML4-ALK融合基因的肺鳞癌患者的短期反应及快速进展：病例报告
Shengshu Li,Xiaosong Du,Xinxin Zhang et al.
Shengshu Li et al.
Background: Anaplastic lymphoma kinase (ALK) rearrangement has been identified in approximately 1% of lung squamous cell carcinomas (LUSCCs). Due to its rarity, the efficacy of anaplastic lymphoma kinase-tyrosine kinase i...
Molecular landscape and biomarker associations of functional NTRK fusions: a real-world retrospective cohort study across solid tumors [0.03%]
功能性NTRK融合的分子图谱及生物标志物相关性的真实世界回顾队列研究（涵盖实体瘤）
Jianuo Zhou,Qinglan Zong,Ruijia Sun et al.
Jianuo Zhou et al.
Background: Although NTRK fusions are actionable targets for a wide array of solid tumors, treatment-relevant biomarkers are heterogeneous and remain incompletely characterized for real-world NTRK fusion-positive populati...
Molecular mechanisms of inhalable iron-containing particles driving lung carcinogenesis through the LCN2 signaling axis revealed by transcriptomic analysis [0.03%]
转录组分析揭示可吸入含铁颗粒物通过LCN2信号轴驱动肺部致癌的分子机制
Lei Wang,Boyi Jiang,Rui He et al.
Lei Wang et al.
Background: Iron, an essential trace element ubiquitously present in living organisms, is integral to various biological processes. Epidemiological studies have shown an elevated relative risk of lung cancer among male in...
Molecular subtyping and prognostic modeling of non-small cell lung cancer based on disulfidptosis-related genes [0.03%]
基于二硫化酶相关基因的非小细胞肺癌分子分型及预后模型构建
Jiaxuan Zhou,Na Li,Haoping Ma et al.
Jiaxuan Zhou et al.
Background: Non-small cell lung cancer (NSCLC) shows substantial molecular and immune heterogeneity, and prognosis varies widely even among patients with similar clinicopathologic stage, highlighting the need for biologic...
KCNK9 could be a prognostic biomarker in uterine corpus endometrial carcinoma [0.03%]
KCNK9可以作为子宫体子宫内膜癌的预后生物标志物
Zhang-Lu An,Yue-Qian Gao,Zhi-Ming Wang et al.
Zhang-Lu An et al.
Background: Uterine corpus endometrial carcinoma (UCEC) incidence is rising, necessitating novel prognostic biomarkers. Potassium two pore domain channel subfamily K member 9 (KCNK9) exhibits oncogenic functions in other ...
Development and validation of machine learning models for predicting synchronous lung metastasis in United States colorectal cancer patients: a SEER database analysis [0.03%]
基于SEER数据库开发和验证美国结直肠癌患者同步肺转移的机器学习预测模型及效度分析
Yuncan Xing,Guanhua Yu,Qingshan Wang et al.
Yuncan Xing et al.
Background: Colorectal cancer lung metastases (CRCLM) significantly influence treatment planning and prognosis in colorectal cancer (CRC). This study aimed to develop and validate machine learning-based models to support ...
Development and internal validation of a prognostic nomogram for lung metastasis in locally advanced rectal cancer incorporating molecular markers [0.03%]
结合分子标志物对局部晚期直肠癌肺转移预后预测模型的建立及内部验证
Shuwen Li,Songsong Wu,Ruiyan Wu et al.
Shuwen Li et al.
Background: Prediction models for lung metastasis in rectal cancer are limited, and gene mutations have not been incorporated. As genetic testing becomes more common in routine clinical practice, including RAS/BRAF mutati...
RNAscope-based HER2 mRNA detection shows high concordance with fluorescence in situ hybridization in invasive breast carcinoma: a retrospective study [0.03%]
基于RNA Scope的HER2 mRNA检测与荧光原位杂交在侵袭性乳腺癌中的高度一致性：一项回顾性研究
Wei Hua,Yunhe Gu,Ying Yuan et al.
Wei Hua et al.
Background: Human epidermal growth factor receptor 2 (HER2) status is critical for guiding targeted therapy in invasive breast cancer (BC). Immunohistochemistry (IHC) is routinely used for HER2 screening, but equivocal (I...
Quetiapine inhibits the oxidative phosphorylation in head and neck squamous cell carcinoma through suppressing NAT10-mediated ac4C modification [0.03%]
喹硫平通过抑制NAT10介导的ac4C修饰抑制头颈鳞癌细胞氧化磷酸化
Shanshan Du,Min Mao,Wanfen Wang et al.
Shanshan Du et al.
Background: N4-acetylcytidine (ac4C) is an RNA epigenetic modification, newly discovered to be catalyzed by the enzyme N-acetyltransferase 10 (NAT10). This study aimed to elucidate the functional role and regulatory mecha...