Plasma-derived exosomal miRNA as a promising diagnostic biomarker for detection of diffuse large B-cell lymphoma [0.03%]
血浆外泌体miRNA作为检测弥漫性大B细胞淋巴瘤的诊断生物标志物的潜力
Yunfei Zhao,Anna Su,Gulimire Adili et al.
Yunfei Zhao et al.
Background: Diffuse large B-cell lymphoma (DLBCL) is a malignant tumor with moderate-high aggressiveness and heterogeneity. In recent years, several studies have shown that tumor cell-derived exosomes are involved in the ...
Jinyang Yuan,Bin Xie,Xiaoqian Wen et al.
Jinyang Yuan et al.
Background: Circular RNAs (circRNAs) act as novel biomarkers associated with drug resistance in triple-negative breast cancer (TNBC). Our previous study has demonstrated that the Wnt/β-catenin pathway mediates TNBC chemo...
Individualized treatment and key prognostic biomarkers based on folate metabolism in patients with pancreatic cancer [0.03%]
基于叶酸代谢的胰腺癌患者个体化治疗及关键预后生物标志物研究
Duan Yan,Yi Liu,Shiyu Tang et al.
Duan Yan et al.
Background: Folate metabolism plays a pivotal role in tumor proliferation. However, the relationship between folate metabolism-related genes (FMGs) and the tumor immune microenvironment (TIME) in pancreatic cancer (PC) re...
Immune profiling in residual disease: refining risk stratification after neoadjuvant therapy in HER2-positive breast cancer [0.03%]
残留病灶的免疫谱分析：新辅助治疗后HER2阳性乳腺癌风险分层的优化
Marcelo Antonini,André Mattar,Francisco Pimentel Cavalcante et al.
Marcelo Antonini et al.
The construction and validation of a nomogram for lung metastasis of intrahepatic cholangiocarcinoma: a study based on the SEER database [0.03%]
基于SEER数据库的肝内胆管癌肺转移列线图的构建和验证
Shanfei Zhu,Jinfu Huang,Fan Wu et al.
Shanfei Zhu et al.
Background: Lung metastasis is the most common extrahepatic metastasis organ for intrahepatic cholangiocarcinoma (ICC), often leading to an unfavorable prognosis. Although nomograms exist for predicting the risk of distan...
Study on the inhibition of thyroid undifferentiated carcinoma metastasis by nanoparticles loaded with EZH2 inhibitor [0.03%]
EZH2抑制剂载药纳米粒子抑制甲状腺未分化癌转移的体内外研究
Shuang Wu,Changzhi Guo,Xiaoyue Zong et al.
Shuang Wu et al.
Background: Anaplastic thyroid carcinoma (ATC) is highly malignant with a poor prognosis. Current treatment methods fail to prolong patients' survival periods, and there is an urgent need to explore new strategies. EZH2 i...
Prognostic value of systemic inflammation indices in patients with metastatic colorectal cancer treated with TAS-102: a single-center retrospective real-world study [0.03%]
TAS-102治疗的转移性结直肠癌患者系统性炎症指标的预后价值：单中心回顾性真实世界研究
Ming Liu,Yue Cui,Lili Chen et al.
Ming Liu et al.
Background: While the efficacy of trifluridine/tipiracil (TAS-102) in late-line metastatic colorectal cancer (mCRC) is established in clinical trials, real-world predictive and prognostic factors remain poorly characteriz...
Curcumin inhibits the proliferation of diffuse large B-cell lymphoma by inducing ferroptosis via the ACSL4-SAT1-GPX4 axis [0.03%]
姜黄素通过ACSL4-SAT1-GPX4轴诱导铁死亡抑制弥漫性大B细胞淋巴瘤的增殖
Xiaohui Gao,Hui Zeng,Xiaoyan Zhao et al.
Xiaohui Gao et al.
Background: Curcumin exhibits anti-inflammatory, antioxidant, and anti-tumor effects. However, its specific mechanisms of action in diffuse large B-cell lymphoma (DLBCL) remain unclear. This study aims to investigate the ...
Development and validation of a cuproptosis-related lncRNA signature for predicting prognosis and immunotherapy response in breast cancer: a retrospective analysis of TCGA data [0.03%]
乳腺癌铜死亡相关长链非编码RNA预后及免疫治疗反应标志物的开发与验证：TCGA数据回顾性分析
Peng Hu,Jianxin Ye,Xiaying Han et al.
Peng Hu et al.
Background: Cuproptosis, a copper-dependent mode of regulated cell death, may expose metabolic liabilities in breast cancer (BRCA). Long non-coding RNAs (lncRNAs) can orchestrate metabolic and immune programs, yet their c...
Stigmasterol reverses rituximab resistance in diffuse large B-cell lymphoma via the MAPK1 signaling pathway [0.03%]
黄酮类化合物芸香苷通过MAPK1信号通路逆转弥漫性大B细胞淋巴瘤Rituximab耐药性的作用研究
Yesheng Wang,Jialin Gu,Jiege Huo
Yesheng Wang
Background: Rituximab (RIT) resistance significantly hampers the treatment efficacy in diffuse large B-cell lymphoma (DLBCL), leading to poor prognosis. We aim to investigate the potential of stigmasterol, a natural compo...