Prognostic role of lymph node-related indices and development/internal validation of a novel nomogram in colorectal cancer patients with synchronous lung metastases: a study based on the SEER database [0.03%]
基于SEER数据库的结直肠癌肺转移患者淋巴结相关指标预后价值及新型预测列线图的创建和内部验证研究
Kexing Xi,Yingyun Xi,Youbo Wu et al.
Kexing Xi et al.
Background: Patients with colorectal cancer (CRC) and synchronous lung metastases face a poor prognosis, yet effective prognostic predictors or models for this specific population remain limited. This study aimed to asses...
Construction and validation of risk prediction model for glioblastoma associated with cancer stem cells and disulfidptosis [0.03%]
与癌症干细胞和不全死亡相关的胶质母细胞瘤风险预测模型的构建及验证
Dang Tang,Zhongkun Ren,Bibo Gao et al.
Dang Tang et al.
Background: Glioblastoma (GBM) is the most common malignant brain tumor, and effective therapeutic strategies remain scarce. Therefore, the study aims to screen biomarkers to reveal the molecular mechanisms of cancer stem...
Identification of potential hub biomarkers for gastric high-grade intraepithelial neoplasia early diagnosis: evidence from gene expression profiles and pathological characters [0.03%]
基因表达谱和病理特征鉴别胃高级别上皮内瘤变潜在生物标志物证据
Dan Yu,Jihan Qi,Xinsheng Nie et al.
Dan Yu et al.
Background: Gastric cancer (GC) is highly prevalent worldwide, and early detection methods are needed to improve patient survival rates. This study aimed to identify crucial biomarkers associated with the progression of g...
A ferroptosis-related competing endogenous RNA network: HOX transcript antisense intergenic RNA/miR-129-5p/brain and acute leukemia, cytoplasmic axis contributes to the malignant progression of esophageal squamous cell carcinoma [0.03%]
与铁死亡相关的竞争性内源RNA网络：HOX反义间隔非编码RNA/miR-129-5p/BALC小脑急性白血病细胞轴促进食管鳞状细胞癌的恶性进展
Hui Cai,Haotian Jin,Diying Jiang et al.
Hui Cai et al.
Background: Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related mortality globally, characterized by high incidence, poor prognosis, and limited therapeutic options. While long non-coding RNAs (...
ZNF460 inhibits HMGCL and promotes PI3K pathway in colon cancer [0.03%]
锌指蛋白ZNF460通过抑制HMGCL促进结肠癌PI3K途径激活
Wenpei Hou,Jia Wang,Yuqiang Wu et al.
Wenpei Hou et al.
Background: Zinc finger protein 460 (ZNF460) is highly expressed in colon cancer, but its specific mechanism of action and downstream targets have not yet been clarified. Therefore, this study aimed to investigate the exp...
Co-assembled structures of Fe3O4 nanoparticles for therapy of cervical cancer by inducing apoptosis and autophagy [0.03%]
通过诱导凋亡和自噬联合治疗宫颈癌的Fe3O4纳米颗粒组装结构研究
Sumiao Dong,Waner Liu,Dou Yu et al.
Sumiao Dong et al.
Background: Cervical cancer is one of the most common cancers among women globally, and its treatments remain limited, urgently needing new strategies. In recent years, the use of enzyme-like Fe3O4 nanoparticles (NPs) has...
Pre-clinical anti-tumor activity and preliminary safety of METTL3 inhibitors STM2457 and UZH1a in neuroblastoma [0.03%]
新型m6A甲基化酶METTL3抑制剂STM2457和UZH1a治疗神经母细胞瘤的抗肿瘤活性及安全性研究
Tian Lin,Xinghe Chen,He Huang et al.
Tian Lin et al.
Background: Neuroblastoma (NB) is one of the most common malignant tumors in children, characterized by high heterogeneity and poor prognosis, posing notable therapeutic challenges. The objective of the present study was ...
Identification of papillary thyroid carcinoma-associated epithelial cell subpopulations and diagnostic biomarkers: integrating machine learning with single-cell analysis [0.03%]
结合单细胞分析与机器学习鉴定乳头状甲状腺癌相关上皮细胞亚群及诊断生物标志物
Xinyu Zhai,Xue Gu,Shengcan Zhang et al.
Xinyu Zhai et al.
Background: Papillary thyroid carcinoma (PTC) represents the most prevalent sort of thyroid malignancy, and its incidence has been consistently increasing worldwide. Although most PTC cases exhibit indolent behavior, a su...
Analysis of prognostic factors in ovarian clear cell carcinoma: a retrospective cohort study [0.03%]
卵巢透明细胞癌预后因素的分析：回顾性队列研究
Xingyun Xie,Yuting Wei,Chenying Liu et al.
Xingyun Xie et al.
Background: Ovarian clear cell carcinoma (OCCC) is a rare histological subtype of ovarian cancer, often associated with endometrial lesions, and characterized by poor prognosis and a high propensity for recurrence and met...
Targeting the gut microbiota-metabolite-immune axis in cancer immunotherapy: mechanistic interplay, therapeutic strategies, and translational applications-a narrative review [0.03%]
针对肿瘤免疫治疗中肠菌-代谢物-免疫轴的靶向作用：机制、策略和转化应用——叙述性综述
Meng Huang,Yunzhao Chen,Xiaobin Cui
Meng Huang
Background and objective: Microbiota and their metabolites form a dynamic regulatory network that modulates the tumor microenvironment (TME) and immune cell functionality, emerging as critical targets in cancer immunother...