Brain tumor detection based on transcription regulation features identified from public cerebrospinal fluid cell-free DNA sequencing data [0.03%]
基于公共脑脊液细胞游离DNA测序数据识别的转录调控特征的脑肿瘤检测方法研究
Sixian Xia,Wei Dai,Jian Wu
Sixian Xia
Background: Characterization of the molecular features of a brain tumor is a critical step for patient treatment. Tissue-based detection methods are limited by the location of brain tumors and high intratumor heterogeneit...
Timing matters: concurrent vs. sequential immunotherapy in combination with chemoradiation in head and neck cancer [0.03%]
时机至关重要：同期与序贯免疫联合放化疗在头颈部肿瘤治疗中的应用
Lindsey M Bachmann,Dalia El-Gamal,Trisha M Wise-Draper
Lindsey M Bachmann
ITPG: an immune-related transcriptomic predictive model for gastric cancer prognosis [0.03%]
基于免疫相关的胃癌预后转录组预测模型ITPG
Musu Li,Yue Sun,Liaowei Zhang et al.
Musu Li et al.
Background: Although the global incidence of gastric cancer (GC) has declined over the past 5 years, it remains the fourth leading cause of cancer-related mortality worldwide. Given the molecular heterogeneity of GC, surv...
Multiomics study on the tertiary lymphatic structure signature of colon cancer [0.03%]
结肠癌三级淋巴结构的多组学研究
Jing Wang,Yuguo Sun,Yan Guo et al.
Jing Wang et al.
Background: Tertiary lymphoid structures (TLSs) are abnormal clusters of immune cells found in inflamed, infected, or cancerous tissues. These structures contain high concentrations of T cells, B cells, plasma cells, foll...
A novel gene signature based on Like-Smith family members-related genes for predicting the prognosis of hepatocellular carcinoma [0.03%]
基于类似史密斯家族相关基因的新型基因特征用于预测肝细胞癌预后
Sijun Chen,Xujian Chen,Xiaofang Sun et al.
Sijun Chen et al.
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths globally. The Like-Smith (LSM) family members are involved in RNA metabolism and tumor progression, but their role in HCC remains...
Exploring the lactate-metabolism related characteristics during the development of medulloblastoma through single-cell and bulk RNA-seq [0.03%]
通过单细胞和批量RNA测序探索乳酸代谢相关特征在髓母细胞瘤发展过程中的作用
Ce Wang,Rong Zhang,Shenglan Li et al.
Ce Wang et al.
Background: Medulloblastoma (MB) is a common central nervous system malignancy in children, and its relationship with lactate metabolism has become an important area of cancer research in recent years, especially in metab...
Comprehensive analysis of liquid-liquid phase separation-related genes in osteosarcoma: implications for prognosis, immune infiltration and drug sensitivity [0.03%]
骨肉瘤中液-液相分离相关基因的全面分析：对预后、免疫浸润和药物敏感性的意义
Cao Han,Zhuo Zhao,Xinghan Zhao et al.
Cao Han et al.
Background: Liquid-liquid phase separation (LLPS) contributes to osteosarcoma (OS) regulatory mechanisms. This investigation focused on evaluating the predictive potential of LLPS-related genes (LRGs) for OS. ...
Single-cell analysis of UNC13D-mediated immune and dedifferentiation heterogeneity in acute myeloid leukemia and development of a prognostic model [0.03%]
基于UNC13D介导的免疫和去分化异质性的单细胞急性髓系白血病分析及其预后模型的开发
Ziqian Wang,Daobin Zhou
Ziqian Wang
Background: Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy, with its pathogenesis closely associated with cellular states at various stages of differentiation. Existing clinical prognostic m...
Construction and validation of a prognostic model associated with chromatin remodeling in hepatocellular carcinoma [0.03%]
与肝细胞癌染色质重塑相关的预后模型的构建和验证
Chuang Zhou,Ding Li,Lin Sun
Chuang Zhou
Background: Abnormal chromatin remodeling figures prominently in the progression and treatment of malignancies. However, the prognostic significance of chromatin remodeling-related genes (CRRGs) in hepatocellular carcinom...
Cuprotosis-related gene subtypes, prognostic modeling, and tumor microenvironment remodeling in breast cancer [0.03%]
铜死亡相关基因亚型、预后建模及乳腺癌肿瘤微环境重塑
Tian-Wei Sun,Min-Yuan Li,Jie Ma et al.
Tian-Wei Sun et al.
Background: A newly discovered mode of cell death is called cuprotosis. Current evidence confirms that cuprotosis is involved in the occurrence and development of malignant tumors. However, the prognostic significance and...