Efficacy and safety of sequential hyperthermic intraperitoneal chemotherapy following surgery for pathological T staging 4 gastric cancer [0.03%]
分期T4胃癌术后序贯HIPEC有效性和安全性的研究
Wei-Long Lian,Li-Sheng Cai,Ming-Qiao Lian et al.
Wei-Long Lian et al.
Background: Peritoneal metastasis influences prognosis and quality of life in patients with gastric cancer. The efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) as postoperative adjuvant therapy for advanced ...
Long-term clinical outcomes with filgotinib in ulcerative colitis: 12-month results from the FILGUITO study [0.03%]
Filgo替尼治疗溃疡性结肠炎的长期临床结果：FILGUITO研究的12个月结果
Antonio M Caballero-Mateos,Claudio Trigo-Salado,Álvaro Suárez-Toribio et al.
Antonio M Caballero-Mateos et al.
Background: Filgotinib, a JAK1-preferential inhibitor, has demonstrated efficacy in pivotal clinical trials for moderate-to-severe ulcerative colitis (UC), leading to regulatory approvals. While emerging real-world studie...
Observational Study
World journal of gastroenterology. 2026 Feb 14;32(6):115941. DOI:10.3748/wjg.v32.i6.115941 2026
Synergistic antitumor effect of oroxylin A and donafenib in hepatocellular carcinoma through tumor protein p53 signaling pathway activation [0.03%]
黄芩素联合多纳非尼通过激活肿瘤蛋白p53信号通路协同抑制肝癌细胞生长转移作用及机制研究
Mei-Yuan Zhang,Rui-Qian Sun,Qi Min et al.
Mei-Yuan Zhang et al.
Background: The clinical application of donafenib in advanced hepatocellular carcinoma (HCC) is restricted by its limited therapeutic efficacy and a variety of treatment-associated adverse events. These factors collective...
Efficacy and safety of a novel sodium picosulfate oral tablet in a randomized controlled trial for bowel preparation [0.03%]
一项随机对照试验中新型硫酸钠口服片剂的疗效及安全性研究
Su Bum Park,Sang Bum Kang,Geom Seog Seo et al.
Su Bum Park et al.
Background: Oral sulfate tablets (OSTs) are commonly used in South Korea, but the requirement to ingest 28 tablets and concerns regarding renal and gastrointestinal safety may reduce patient compliance. DWJ1609 is a novel...
Predictors of one-year adverse outcomes after laparoscopic resection for hepatocellular carcinoma: Development and validation of an early-warning model [0.03%]
肝细胞癌腹腔镜切除术后一年内不良预后的预测因素：早期预警模型的构建和验证
Wei Feng,Qing-Wang Ye,Qi-Le Wang et al.
Wei Feng et al.
Background: The global burden of primary liver cancer (PLC) continues to rise. Although minimally invasive, especially laparoscopic, resection is increasingly performed for early-stage disease, 1-year adverse outcomes (re...
Emerging role of DNA polymerase epsilon non-exonuclease domain mutations in colorectal cancer: From sequence variants to clinical implications [0.03%]
DNA聚合酶epsilon非核酸外切域突变在结直肠癌中的作用及临床意义
Jia-Ju Xu,Chun-Xiao Ni,Jia-Ju Xu
Jia-Ju Xu
This editorial highlights the emerging significance of non-exonuclease domain mutations (non-EDMs) in DNA polymerase epsilon (POLE) in colorectal cancer (CRC), inspired by the recent study by Taskiran et al. Their study revealed an exceptio...
Endocrine-liver bidirectional regulation: From mechanistic research to multidisciplinary clinical practice [0.03%]
内分泌-肝脏双向调控研究：从机制解析到多学科临床实践
Kai-Rui Wan,Cheng Qian,Li-Mei Liu
Kai-Rui Wan
A close bidirectional regulatory network exists between endocrine disorders and liver dysfunction, and their reciprocal imbalance is a key driver of metabolic liver diseases and chronic liver diseases. Based on the review, this letter syste...
Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages [0.03%]
乳果糖结合益生菌对DA致肠上皮屏障损伤及巨噬细胞M1极化的保护机制研究
Peng-Chun Yang,Chun-Yan Xiao,Jing Wang et al.
Peng-Chun Yang et al.
Background: A high-fat diet (HFD) can cause systemic low-grade inflammation, metabolic and inflammatory diseases, and alter the composition of intestinal microbiota. Although probiotics mitigate intestinal inflammation, i...
Insights into the influencing factors of fecal gut microbiota in hepatocellular carcinoma [0.03%]
肝细胞癌肠道微生物群影响因素的研究进展
Yin-Ping Wang,Jia-Le Dai,Lan Li et al.
Yin-Ping Wang et al.
Recently, Feng et al published a significant study. Through multi-omics analysis, their research team revealed associations between fecal metabolome, gut bacteria, and serum indicators in patients with hepatocellular carcinoma (HCC). These ...
Effects of bariatric surgery on obesity associated gastroesophageal reflux disease: Insights from a systematic review and network meta-analysis [0.03%]
代谢手术治疗肥胖相关胃食管反流病的疗效分析：系统评价和网状Meta分析
Ying Xing,Wen-Mao Yan,Ri-Xing Bai
Ying Xing
Background: Obesity is a global epidemic frequently associated with gastroesophageal reflux disease (GERD). Metabolic and bariatric surgery (MBS) is the most effective treatment for weight reduction in patients with obesi...