ALK-tyrosine kinase inhibitor resistance due to acquired MET amplification in ALK-fusion positive advanced NSCLC effectively treated by lorlatinib-vebreltinib combination: a case report and literature review [0.03%]
获得性MET扩增导致的ALK融合阳性晚期NSCLC对ALK酪氨酸激酶抑制剂耐药，采用劳拉替尼和维博瑞汀联合治疗有效：一例报告及文献回顾
Peng Song,Dahong Liu,Yi Liu
Peng Song
Background: Molecular testing has become an essential part of managing non-small cell lung cancer (NSCLC). The detection of EGFR, BRAF, and MNNG HOS transforming gene (MET) mutations, and the analysis of anaplastic lympho...
Perioperative anxiety and depression predict long-term survival after neoadjuvant therapy in non-small cell lung cancer: a multicenter analysis [0.03%]
术前焦虑和抑郁可预测新辅助治疗后非小细胞肺癌患者的长期生存：一项多中心分析研究
Yuxing Lin,Qichang Xie,Maojie Pan et al.
Yuxing Lin et al.
Background: Anxiety and depression are common yet not timely valued in thoracic oncology. The prognostic value of perioperative trajectories of anxiety and depression has not been well-quantified in neoadjuvant-treated. T...
Perioperative inflammation, anesthesia modulation and cellular signaling in lung cancer: an integrated transcriptomic and single-cell analysis [0.03%]
基于转录组和单细胞的肺癌围术期炎性反应、麻醉调控及细胞信号转导集成分析
Weixiang Lu,Qing Ai,Ze Wang et al.
Weixiang Lu et al.
Background: Patients undergoing lung cancer surgery experience significant systemic inflammatory responses and anesthetic interventions during the perioperative period, which can affect immune status and the tumor microen...
Clonal relationship in a rare pulmonary mixed tumor: shared ALK fusion in atypical carcinoid and adenocarcinoma-a case report [0.03%]
罕见肺混合瘤的克隆关系：atypical carcinoid和腺癌共有的ALK融合-病例报告
Kyoung Min Kim,Jong Hun Kim,Myoung Ja Chung
Kyoung Min Kim
Background: Pulmonary mixed neuroendocrine and non-neuroendocrine neoplasms (MiNENs) are currently described in the World Health Organization (WHO) classification primarily as combinations of non-small cell lung cancer (N...
Pre-clinical efficacy of trastuzumab deruxtecan plus sotorasib in KRASG12C -mutant non-small cell lung cancer and exploratory HER2 profiling in human tumors [0.03%]
新型抗癌药组合治疗非小细胞肺癌的临床前有效性研究及人源肿瘤HER2探索性谱分析
Hilal Ozakinci,Bina Desai,Denise Kalos et al.
Hilal Ozakinci et al.
Background: KRASG12C inhibitors such as adagrasib and sotorasib have shown promise in treating KRASG12C- mutant non-small cell lung cancer (NSCLC), but treatment resistance remains a major challenge. In this study, we inv...
Evaluating the early therapeutic response of radiofrequency ablation in rabbit VX2 lung tumors: a comparison of four diffusion weighted imaging models [0.03%]
四种扩散加权成像模型评估兔VX2肺肿瘤射频消融早期疗效的对比研究
Qinqin Yan,Wen Ye,Fei Shan et al.
Qinqin Yan et al.
Background: Radiofrequency ablation (RFA) is a widely used treatment for unresectable lung tumors; however, conventional anatomical imaging has limited ability to assess early treatment response, while functional paramete...
Prognostic nomogram for extensive-stage small-cell lung cancer in the immunotherapy era: a multicenter study of first-line platinum-etoposide with or without a PD-1/PD-L1 inhibitor [0.03%]
免疫治疗时代广泛期小细胞肺癌预后预测列线图：一线铂类-依托泊苷联合或不联合PD-1/PD-L1抑制剂多中心研究
Yuhao Jing,Yifan Zhao,Zhenbao Zhou et al.
Yuhao Jing et al.
Background: In the immunotherapy era, most patients with extensive-stage small-cell lung cancer (ES-SCLC) still experience early progression, whereas only a minority derive more durable benefit. Most existing prognostic m...
Distinct mutation landscape with similar immune microenvironment in primary simultaneous operable squamous cell carcinoma and peripheral-type small-cell lung cancer [0.03%]
原发性可手术鳞状细胞癌和周围型小细胞肺癌具有不同的突变特征但相似的免疫微环境
Xiaoke Chen,Liqiang Qian,Jia Huang et al.
Xiaoke Chen et al.
Background: Patients with both primary simultaneous squamous cell carcinoma (SQ) and peripheral-type small-cell lung cancer (SCLC) are extremely rare clinically, and an in-depth molecular characterization and tumor microe...
Methylated circulating tumor DNA: technical challenges and clinical applications in non-small cell lung cancer patients-a narrative review [0.03%]
血甲基化循环肿瘤DNA的技术挑战及在非小细胞肺癌患者中的临床应用-综述文章
Manon Robert,Chloé Sauzay,Sandrine Théoleyre et al.
Manon Robert et al.
Background and objective: Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Tissue biopsies are invasive and often limite...
Identification of prognostic biomarkers and immunotherapy response predictors in lung adenocarcinoma: integrative Mendelian randomization and machine learning analysis [0.03%]
基于孟德尔随机化和机器学习分析的肺腺癌预后生物标志物及免疫治疗反应预测因子鉴定研究
Chenlin Cao,Wan Qin,Ruoxuan Gong et al.
Chenlin Cao et al.
Background: Lung adenocarcinoma (LUAD), the most prevalent and clinically heterogeneous form of lung cancer, lacks robust biomarkers for prognosis and immunotherapy response prediction. This study aimed to identify key pr...