Adjuvant chemotherapy for completely resected stage IB-IIA non-small cell lung cancer according to the AJCC 8th edition staging system: a real-world retrospective cohort study based on the SEER database [0.03%]
基于AJCC第八版分期系统的SEER数据库真实世界队列研究：II期非小细胞肺癌患者术后辅助化疗的疗效分析
Zewen Sun,Changtai Zhao,Kexin Feng et al.
Zewen Sun et al.
Background: Whether adjuvant chemotherapy confers greater survival benefit than observation alone in patients with completely resected stage IB-IIA non-small cell lung cancer (NSCLC), particularly those with high-risk fea...
NOTCH4 as a driver of epithelial-mesenchymal transition, angiogenesis, and stromal remodeling in lung adenocarcinoma: integrated transcriptomic and protein-level validation [0.03%]
NOTCH4通过整合转录组和蛋白水平验证促进肺腺癌上皮间质转化、血管生成及间质重塑的作用机制研究
Young Wha Koh,Jae-Ho Han,Seokjin Haam et al.
Young Wha Koh et al.
Background: Although NOTCH4 plays an important role in tumor progression, its role in lung adenocarcinoma (LUAD) remains unclear. We examined the role of NOTCH4 in LUAD progression, its influence on the tumor microenviron...
Integrated management of immunotherapy and radiotherapy for patients with metastatic non-small cell lung cancer: a narrative review of current landscape and future directions [0.03%]
免疫治疗与放疗在转移性非小细胞肺癌患者中联合应用的管理：现状及未来方向叙事综述
Xinquan Liang,Fengxue Li,Yingying Zhang et al.
Xinquan Liang et al.
Background and objective: Despite advancements in systemic therapy, metastatic non-small cell lung cancer (NSCLC) remains largely incurable. Immunotherapy, primarily immune checkpoint inhibitors (ICIs), has improved outco...
A radiomics nomogram integrated with radiological features for preoperative prediction of lung nodule invasiveness: comparison with Lung-RADS [0.03%]
基于影像组学的列线图模型预测肺结节恶性侵犯价值研究：与Lung-RADS对比
Siwei Miao,Zhaojie Han,Fei Wang et al.
Siwei Miao et al.
Background: Preoperative identification of early-stage lung adenocarcinoma, particularly minimal lesions, holds critical implications for clinical decision-making. However, accurate diagnosis of pulmonary nodules' maligna...
Development and validation of a habitat-based computed tomography radiomics model for differentiating isolated lung cancer, isolated tuberculoma, and coexistence of tuberculosis with lung cancer: a dual-center retrospective study [0.03%]
基于生境的CT影像组学模型在孤立型肺癌、孤立型肺结核球及并存肺结核与肺癌之间的鉴别诊断中应用的价值研究：一项双中心回顾性研究
Ning Shi,Zhenzhen Wan,Limin Wen et al.
Ning Shi et al.
Background: Isolated lung cancer (ILC), isolated tuberculoma, and coexistence of tuberculosis with lung cancer (CTBLC) exhibit similarities in computed tomography (CT) imaging features but great differences in pathology, ...
Mediastinal staging and restaging techniques in locally advanced non-small cell lung cancer in the era of neoadjuvant and perioperative chemoimmunotherapy-a narrative review [0.03%]
新辅助和围手术期免疫化疗时代的局部晚期非小细胞肺癌的纵隔分期和再分期技术-叙述性综述
María Izquierdo-Chamarro,Aylen Vanessa Ospina-Serrano,Mariano Provencio-Pulla
María Izquierdo-Chamarro
Background and objective: Lung cancer (LC) is the leading cause of cancer-related death in worldwide. Approximately 70% of patients have advanced or locally advanced non-small cell lung cancer (LA-NSCLC) at diagnosis, whi...
B cell-driven refractory hemocytopenia in immune checkpoint inhibitor therapy: a report of two cases [0.03%]
免疫检查点抑制剂治疗相关的B细胞驱动型难治性血细胞减少症两例报告
Feng Li,Chunyan Wang,Guohua Yao et al.
Feng Li et al.
Background: The integration of immune checkpoint inhibitors (ICIs) with chemotherapy has revolutionized lung cancer treatment, yet it amplifies the risk of severe hematologic toxicities. ...
Neoadjuvant or conversion anti-PD-1/PD-L1 immunotherapy combined with chemotherapy improves 2-year survival and achieves high pathological complete response rate in patients with stage IIB-IIIB small-cell lung cancer [0.03%]
新辅助或转化抗PD-1/PD-L1免疫疗法联合化疗可提高IIb至IIIb期小细胞肺癌患者的2年生存率并实现较高的病理完全缓解率
Zhiyuan Gao,Zhengxuan Li,Xin Yao et al.
Zhiyuan Gao et al.
Background: Limited-stage small-cell lung cancer (LS-SCLC) is an aggressive malignancy, and patients with this disease have a poor long-term survival when treated with current standard chemoradiotherapy. Although neoadjuv...
Proposal on incorporating consolidation-to-tumor ratio into the clinical T1 classification in patients with invasive lung adenocarcinoma [0.03%]
关于在浸润性肺腺癌患者中将巩固瘤比纳入临床T1期分类的建议
Molin Zhang,Chaoqiang Deng,Fangqiu Fu et al.
Molin Zhang et al.
Background: The prognostic implication of consolidation-to-tumor ratio (CTR) in patients with part-solid nodules (PSNs) remains ambiguous. The aim of this study is to explore the potential of CTR for refining prognostic s...
The 2025 lung cancer landscape: advances in screening, molecular taxonomy and therapeutic strategy: a narrative review [0.03%]
2025年肺癌格局：筛查、分子分类和治疗策略进展：叙述性综述
Wenhai Fu,Xusen Zou,Tianrui He et al.
Wenhai Fu et al.
Background and objective: In 2025, lung cancer research advanced rapidly across the disease continuum, from population-level risk assessment and screening to mechanistic studies of early carcinogenesis and therapeutic inn...