Zinc Therapy in Mild Cognitive Impairment: Cognitive Stabilization in Pharmacodynamically Responsive Patients in the ZINCAiD Trial [0.03%]
微量锌治疗轻度认知障碍：ZINCAiD试验中药动学有反应的患者的认知功能稳定化
Rosanna Squitti,Alberto Benussi,Silvia Fostinelli et al.
Rosanna Squitti et al.
Dysregulation contributes to Alzheimer's disease (AD) pathophysiology. Zinc therapy promotes enterocyte copper sequestration, potentially reducing systemic copper. Individual biological responses may vary. ...
Clinical Trial
Biomolecules. 2025 Sep 1;15(9):1268. DOI:10.3390/biom15091268 2025
PPARγ Agonism Modulates Synovial Macrophage and Cartilage Responses in an Equine Model of Synovial Inflammation-Implications for Joint Therapy [0.03%]
PPARγ激动剂调节马滑膜炎模型中滑膜巨噬细胞和软骨的反应及其对关节治疗的影响
Slàine F Chaimbeul,Nubia N P Rodrigues,Danny D Thurston et al.
Slàine F Chaimbeul et al.
Synovitis resolution is critical for joint homeostasis and prevents the progression of osteoarthritis (OA). Treatments like NSAIDs and intra-articular corticosteroids relieve symptoms by blocking pro-inflammatory mediators, but also impair ...
From Obscurity to Prominence: IPMK's Expanding Role in Cellular Signaling, Physiology, and Disease [0.03%]
从鲜为人知到备受关注：IPMK在细胞信号转导、生理学和疾病中的作用日益重要
Subrata H Mishra,Sujan Chatterjee,Loretta Viera-Preval et al.
Subrata H Mishra et al.
Once a protein of relative obscurity, inositol polyphosphate multikinase (IPMK) emerged as a versatile and indispensable enzyme in cellular biology. With dual inositol and lipid kinase activities, IPMK generates pivotal signaling molecules ...
Pharmacological Characterization of the Novel CRF1 Receptor Antagonist, Thiazolo[4,5-d] Pyrimidine Analog, M43 [0.03%]
新型CRF1受体拮抗剂噻唑并[4,5-D]吡啶类似物M43的药理学特征研究
Spyridon Marios Giatro,George Komontachakis,Aikaterini Kalantidou et al.
Spyridon Marios Giatro et al.
The corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1R) play a key role in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Dysregulation of the HPA axis is associated with congenital adrenal hyperplasia (CA...
Isotopic N, N-Dimethyl Leucine-Based Mass Spectrometric Quantification of Metabolites Following Copper Exposure [0.03%]
铜暴露后基于同位素N,N-二甲基亮氨酸的代谢组学定量分析mass spectrometry（质谱法）
Olga Riusech,Lingjun Li
Olga Riusech
Crustaceans are particularly sensitive to copper toxicity, and although the downstream effects of increased copper exposure on the metabolome are often postulated and observed, they are rarely measured. To perform absolute quantification of...
Neutrophil Extracellular Traps in Cardiovascular Diseases: Pathological Roles and Therapeutic Implications [0.03%]
中性粒细胞胞外诱捕网与心血管疾病：病理作用及治疗意义
Yan Ma,Jun Zhang,Yaxuan Qi et al.
Yan Ma et al.
Cardiovascular disease (CVD) is currently recognized as one of the leading health threats to humanity. Neutrophils play an important role in innate immune response. The activation of neutrophils leads to the release of neutrophil extracellu...
Neuromyotonia and CASPR2 Antibodies: Electrophysiological Clues to Disease Pathophysiology [0.03%]
CASPR2抗体相关的神经肌阵挛症的电生理特征及疾病病理生理机制探究
João Moura,Pietro Antenucci,Ester Coutinho et al.
João Moura et al.
Contactin-associated protein-like 2 (CASPR2) is a transmembrane protein of the neurexin superfamily, essential for clustering voltage-gated potassium channels, particularly Kv1, at the juxtaparanodal regions of myelinated axons. This precis...
Drucy Borowitz
Drucy Borowitz
Although the pancreas is the organ that produces the most critical digestive enzymes, there are other important contributors to the cleavage of food into absorbable units. Pre-pancreatic digestion of carbohydrates occurs through the action ...
The Effects of Microgravity on the Structure and Function of Cardiomyocytes [0.03%]
微重力对心肌细胞结构和功能的影响
Luis Fernando González-Torres,Daniela Grimm,Marcus Krüger
Luis Fernando González-Torres
Spaceflight and microgravity (μg) environments induce numerous cardiovascular changes that affect cardiac structure and function, and understanding these effects is essential for astronaut health and tissue engineering in space. This revie...
Modulating Effect of Carbohydrate Antigen 125 on the Prognostic Value of High-Sensitivity C-Reactive Protein in Heart Failure [0.03%]
心脏衰竭患者中糖类抗原125对高灵敏度C反应蛋白预后价值的调节作用
Enrique Santas,Arancha Martí-Martínez,Elena Revuelta-López et al.
Enrique Santas et al.
Inflammation and congestion are key pathophysiological processes in heart failure (HF). Our aim was to evaluate the potential modulatory effect of carbohydrate antigen 125 (CA125) on inflammation, assessed by high-sensitivity C-reactive pro...