Transcriptomic Profiling Identifies Disease-Specific miRNA-mRNA Regulatory Networks in Systemic Sclerosis [0.03%]
基于系统性硬化症的转录谱分析鉴定疾病特异性miRNA-mRNA调控网络
Dóra Csige,János Rózsa,Monika Bodoki et al.
Dóra Csige et al.
Systemic sclerosis (SSc) is a severe autoimmune rheumatic disease with high mortality. Epigenetic factors, particularly micro-RNAs (miRNAs), may contribute to its pathogenesis by regulating gene expression. In this cross-sectional study, we...
Extracellular Particles Isolated from Leftover Discarded Formalin-Fixed Tissues Exhibit Atypical Extracellular RNA Profiles [0.03%]
废弃甲醛固定组织的细胞外颗粒表现出非典型的细胞外RNA谱型
Vyshnavi Tallapaneni,Bryson C Okeoma,Ravi Sachidanandam et al.
Vyshnavi Tallapaneni et al.
This study reports atypical findings indicating that extracellular particles (EPs) isolated from leftover discarded formalin-fixed tissues (FFTs) contain atypical RNA profiles that may be highly fragmented. Using particle purification liqui...
Molecular Networks and Key Regulators Underlying Resilience of the Human Brain to Aging and Dementia [0.03%]
人类大脑抵抗衰老和痴呆的分子网络及关键调节因子
Lei Guo,Nicholas Grimaldi,Minghui Wang et al.
Lei Guo et al.
Alzheimer's disease (AD) is an aging-related neurodegenerative disease characterized by an initial memory impairment that progresses to a widespread cerebrocortical failure, culminating in death. Understanding the molecular mechanisms that ...
Brandon T James,Emma P Kosmeder,Meng Wang
Brandon T James
Reactive aldehydes are potent electrophiles that damage DNA and can ultimately promote cancer. While many aldehydes are ubiquitous in the environment, mammalian metabolism also generates high levels of endogenous aldehydes sufficient to thr...
Sensitive Molecules Involved in Spatial Learning and Memory Impairment of Mice Induced by 4.3 GHz Microwave Radiation [0.03%]
4.3吉赫兹微波辐射诱导小鼠空间学习记忆损伤的相关敏感分子研究
Tingting Qian,Wenjing Cheng,Lequan Song et al.
Tingting Qian et al.
With the widespread application of microwave technology in communication and medical fields, concerns regarding its biosafety, particularly the effects on the central nervous system, have increased. The brain is considered a sensitive targe...
Traditional Chinese Medicine Intervention Based on Metabolic-Epigenetic Axis: Mechanism and Treatment Strategy of Chronic Heart Failure [0.03%]
基于代谢-表观遗传轴的中医干预：慢性心力衰竭治法方药的科学内涵研究机制及策略探讨
Ji-Chao He,Jia-Ming Wei,Bin Wang et al.
Ji-Chao He et al.
Chronic heart failure [CHF] is a progressive clinical syndrome characterized by structural and functional impairment of the myocardium, in which energy metabolic remodeling plays a central role. Increasing evidence suggests that metabolic d...
Reduced Synaptophysin-like 2 (MG29/SYPL2) Levels Mimic Age-Related Alterations in Skeletal Muscle Calcium Homeostasis and Lipid Signaling [0.03%]
类肌球蛋白受体A/synaptophysin like 2(Myrfa/Sypl2)水平下降影响骨骼肌钙代谢和脂质信号通路事件模仿衰老相关变化
Kamal Awad,Jian Huang,Marian N Aziz et al.
Kamal Awad et al.
Sarcopenia is characterized by progressive loss of skeletal muscle mass and function and is a major contributor to frailty, disability, and mortality in older adults. Store-operated calcium entry (SOCE) is a crucial regulator of skeletal mu...
Mitochondria-Targeting Metal Complexes: Design Principles, Mechanisms of Action, and Translational Perspectives [0.03%]
线粒体靶向金属复合物：设计原则、作用机制及转化前景
Donatella Coradduzza,Giacomo Senzacqua,Rosita Cappai et al.
Donatella Coradduzza et al.
Mitochondria-targeting metal complexes (MTMCs) are a mechanistically distinct class of metallopharmaceuticals. Unlike first-generation platinum drugs that form nuclear DNA adducts, MTMCs exploit organelle-specific vulnerabilities such as hy...
Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular Mechanisms [0.03%]
从分子机制角度探究听力损失与认知障碍的关系
Lu Wang,Ziqi Zhou,Xingqian Shen et al.
Lu Wang et al.
Dementia is primarily characterized by cognitive dysfunction, which is one of the major causes of disability. As hearing loss has been identified as the largest modifiable risk factor for dementia, understanding the intrinsic relationship b...
Apolonia Witecka,Julia Zuzanna Kamińska,Klaudia Ślusarczyk et al.
Apolonia Witecka et al.
Orphan enzymes are recognized and classified enzymatic activities that lack associated amino acid sequences. Since the term was coined in the mid-2000s, the proportion of orphan enzymes has substantially decreased; however, it is estimated ...