Nanocomposite Biomaterials for Tissue-Engineered Hernia Repair: A Review of Recent Advances [0.03%]
组织工程疝修补的纳米复合生物材料研究进展综述
Octavian Andronic,Alexandru Cosmin Palcau,Alexandra Bolocan et al.
Octavian Andronic et al.
Hernia repair is among the most frequent procedures in general surgery, traditionally performed with synthetic meshes such as polypropylene. While effective in reducing recurrence, these materials are biologically inert and often trigger ch...
Marilena Di Salvo,Alessandra Ventre,Enrica Dato et al.
Marilena Di Salvo et al.
Antioxidant mechanisms consist of both enzymatic and non-enzymatic compounds, which can be either endogenous or exogenous and play a crucial role in counteracting oxidative stress. These compounds are primarily obtained through the diet. Ve...
MYC and Metabolomics: Can We Use What We Know for DLBCL Subtyping and Diagnosis? [0.03%]
MYC和代谢组学：我们能否利用现有的知识对DLBCL进行分类和诊断？
Adrian Florentin Suman,Davide De Luca,Melania Gaggini et al.
Adrian Florentin Suman et al.
Diffuse large B-cell lymphoma (DLBCL) is a molecular and clinical heterogenous entity, and, over the past 30 years, many efforts have been made in trying to dissect this diverseness and identify biomarkers capable of efficiently stratifying...
Perspectives on Alzheimer's Disease Treatment Based on Counteracting Oxidative Stress [0.03%]
基于对抗氧化应激的阿尔茨海默病治疗观点
Rafał Bilski,Stanisław Dąbkowski,Igor Kozieł et al.
Rafał Bilski et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and one of the most pressing global health challenges. Increasing evidence highlights oxidative stress as a key factor in its pathogenesis, contributing to amyloid-β accu...
NLRP3 Inflammasome in Stress-Related Neuropsychiatric Disorders: Mechanisms of Neuron-Microglia-Astrocyte Crosstalk, HPA Axis Dysregulation, and Therapeutic Perspective [0.03%]
应激相关神经精神障碍中的NLRP3炎性小体：神经元-小胶质细胞-星形胶质细胞串话、HPA轴功能失调及治疗靶点展望
Izabela Woźny-Rasała,Ewa Alicja Ogłodek
Izabela Woźny-Rasała
Chronic stress disrupts neuroimmune homeostasis and initiates CNS inflammation. This paper examines the molecular and cellular mechanisms that connect stress to the interplay among the nervous, endocrine, and immune systems, with a focus on...
Interaction Between Heparan Sulfate Oligosaccharide and the Receptor-Binding Domain of the Wild-Type and Omicron Variant of the SARS-CoV-2 Spike Protein [0.03%]
硫酸肝素寡糖与野生型和omicron变异株SARS-CoV-2刺突蛋白受体结构域的相互作用
Marco Mandalari,Michela Parafioriti,Minghong Ni et al.
Marco Mandalari et al.
Heparan sulfate proteoglycans serve as initial attachment sites for several viruses and bacteria. Recent studies suggest that SARS-CoV-2 similarly exploits these glycosaminoglycans, facilitating conformational changes in the spike protein t...
Role of Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) in Patients with Chronic Heart Failure [0.03%]
glucagon样肽-1受体激动剂(GLP-1RA)治疗慢性心力衰竭患者的疗效及机制研究进展
Pasqual Llongueras-Espí,Elena García-Romero,Josep Comín-Colet et al.
Pasqual Llongueras-Espí et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in the management of type 2 diabetes and obesity due to their metabolic benefits. Beyond weight loss and glycemic control, emerging evidence suggests they may also exert c...
Investigation of the Effect of 2,3-Dihydrobenzoic Acid Acid (2,3-DHBA) on the Lipid Profiles of MCF-7 and MDA-MB-231 Human Breast Cancer Cells via an Untargeted Lipidomic Approach [0.03%]
采用非靶向脂质组学方法研究2,3-氢化苯甲酸(2,3-DHBA)对人乳腺癌MCF-7和MDA-MB-231细胞脂质轮廓的影响
Büşra Daş,Serap Şahin
Büşra Daş
Breast cancer (BC) is a primary cause of cancer-related mortality in women, making the development of novel therapeutic strategies essential. Altered lipid metabolism is a recognized hallmark of cancer, presenting a key therapeutic vulnerab...
Allosteric Control Overcomes Steric Limitations for Neutralizing Antibodies Targeting Conserved Binding Epitopes of the SARS-CoV-2 Spike Protein: Exploring the Intersection of Binding, Allostery, and Immune Escape with a Multimodal Computational Approach [0.03%]
别构调控克服了中和抗体靶向SARS-CoV-2刺突蛋白保守结合表位的立体位阻限制：采用多模式计算方法探索结合、别构和免疫逃逸的交汇点
Mohammed Alshahrani,Vedant Parikh,Brandon Foley et al.
Mohammed Alshahrani et al.
Understanding the atomistic basis of multi-layer mechanisms employed by broadly reactive neutralizing antibodies of the SARS-CoV-2 spike protein without directly blocking receptor engagement remains an important challenge in coronavirus imm...
Mitochondrial Reactive Oxygen Species: A Unifying Mechanism in Long COVID and Spike Protein-Associated Injury: A Narrative Review [0.03%]
线粒体反应性氧簇：长期新冠和刺突蛋白相关损伤的统一机制：叙述性综述
Eunseuk Lee,Adaobi Amelia Ozigbo,Joseph Varon et al.
Eunseuk Lee et al.
Post-acute sequelae of SARS-CoV-2 infection (long COVID) present with persistent fatigue, cognitive impairment, and autonomic and multisystem dysfunctions that often go unnoticed by standard diagnostic tests. Increasing evidence suggests th...