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Increasing Bioactive Compound Production in Lettuce by Application of Trichoderma sp. Strain STP8 [0.03%]
利用尖孢镰刀菌STP8增加生菜中有益次级代谢产物的积累
Božidar Benko,Mia Dujmović,Sanja Radman et al.
Božidar Benko et al.
Improving the nutritional quality of food through advanced and sustainable agricultural practices has become a key objective of modern vegetable crop production. Emphasis is placed on increasing the content of health-promoting bioactive com...
Dubravka Svob Strac,Vedrana Filic,Ana Filosevic Vujnovic et al.
Dubravka Svob Strac et al.
Mitochondrial dysfunction is increasingly recognized as a major contributor to central nervous system (CNS) disorders, including neurodegenerative and neuropsychiatric diseases. Animal models are essential for elucidating disease mechanisms...
Integrative Multi-Omics Reveal Metabolic Reprogramming by Ketogenic Diet in Melanoma Xenografts [0.03%]
整合多组学揭示酮体饮食通过重新编程代谢治疗黑色素瘤异种移植模型
Rohit Dnyansagar,Natalie Bordag,Rodolphe Poupardin et al.
Rohit Dnyansagar et al.
The ketogenic diet (KD) has demonstrated anti-proliferative effects across multiple tumor types, yet the underlying metabolic and transcriptomic mechanisms remain incompletely understood. This study employed integrated multi-omics analysis ...
GDF15: A Hijacked Metabo-Hormone Orchestrating Cachexia and Immunosuppression in Cancer [0.03%]
癌症恶病质和免疫抑制中的被劫持代谢激素GDF15的作用机制研究
Dong-Yang Qi,Yong-Fei Wang,Wei-Lin Jin
Dong-Yang Qi
Cancer is responsible for systemic burdens, most notably cachexia and immunosuppression, that extend far beyond local tumor growth and collectively dictate poor outcomes. While often studied separately, these debilitating syndromes are deep...
Coffee Pulp and Silverskin Mitigate Fructose-Induced Intestinal Alterations in Rats [0.03%]
咖啡果皮和银皮缓解大鼠肠内果糖异常现象研究
Francisca Silva,Nelson Andrade,Ilda Rodrigues et al.
Francisca Silva et al.
Excessive fructose consumption is associated with metabolic syndrome (MS). This study evaluated the effect of two coffee by-products, coffee pulp (CP) and coffee silverskin (SK), on fructose-induced intestinal changes. Sprague-Dawley rats w...
Helicobacter pylori Vacuolating Cytotoxin A: Structure, Biological Functions, Genetic Polymorphisms, and Therapeutic Perspectives [0.03%]
幽门螺杆菌细胞毒伴性菌毛A:结构、生物学功能、基因多态性和治疗前景
Xiaona Song,Xiaoqiong Tang,Alfred Tay et al.
Xiaona Song et al.
VacA (vacuolating cytotoxin A) is a key virulence factor in Helicobacter pylori infection, contributing to chronic gastritis and gastric adenocarcinoma. It induces vacuolation, disrupts cellular functions, and modulates immune responses, ai...
The Cytoplasmic Domain of MHC Class I Molecules as a Molecular Switch: A Perspective from Short Linear Motifs and Intrinsically Disordered Regions [0.03%]
MHC I类分子胞浆肽段的动态调控机制——SLiMs和IDRs角度的新观点
Fernando A Arosa,Elsa M Cardoso
Fernando A Arosa
Classical Major Histocompatibility Complex Class I (MHC-I) molecules are traditionally viewed as stable peptide-presenting structures expressed on the surface of all nucleated cells. Their expression by professional antigen-presenting dendr...