Expression of Anion Exchanger 1 (AE1) and Its Potential Involvement in Human Granulosa Cell Physiology: An In Vitro Pilot Study [0.03%]
阴离子交换器1(AE1)在人颗粒细胞中的表达及其潜在作用机制的体外研究初探
Loris Marin,Chiara Sabbadin,Claudia Maria Radu et al.
Loris Marin et al.
The anion exchanger 1 (AE1), traditionally known for its role in erythrocyte anion transport and acid-base homeostasis, has recently been identified in non-erythroid tissues, suggesting broader physiological functions. In the present study,...
Sulfhydryl Sulfobetaine Stabilized Palladium Nanoparticles with High Peroxidase-like Activity for Enhanced Glutathione Detection and Tumor Suppression [0.03%]
用于增强谷胱甘肽检测和肿瘤抑制的高类过氧化物酶活性的硫醇硫酸胆碱稳定型钯纳米颗粒
Ruyu Li,Yanshuai Cui,Shukai Li et al.
Ruyu Li et al.
Glutathione (GSH)-responsive nanozymes have attracted increasing attention for biosensing and cancer therapy. However, their practical applications are often limited by aggregation and insufficient catalytic activity. Herein, we report a zw...
Design, Synthesis, and Biological Evaluation of Novel Morpholine-Coumarin Derivatives for Inflammation-Associated Depression [0.03%]
新型吗啉香豆素衍生物的设计、合成及炎症相关抑郁活性评价
Hui Liu,Lina Hu,Yalan Wang et al.
Hui Liu et al.
The tryptophan-kynurenine pathway, mediated by indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), is critically involved in the pathogenesis of depression. A series of novel morpholine-coumarin derivatives were desig...
Evaluation of Topical Reconstituted HDL as a Treatment for Diabetic Wounds in Murine and Porcine Models [0.03%]
评估 topical reconstituted HDL 治疗糖尿病伤口的疗效：小鼠和猪模型研究
Juan E Camacho Londoño,Sharelle Sturgeon,Yun Dai et al.
Juan E Camacho Londoño et al.
Chronic, non-healing foot ulcers are the most common complication of diabetes and are associated with high morbidity, mortality, and substantial health-care costs. Impaired wound healing in diabetes results from a complex pathophysiology in...
Bioelectrical Regulation of Vascular Endothelial Function in Atherosclerosis [0.03%]
动脉粥样硬化中的血管内皮功能的生物电调节作用研究
Julienne Marie Custodio,Jianhua J Liu,Lu Zhang et al.
Julienne Marie Custodio et al.
Atherosclerosis is a chronic inflammatory disease characterized by progressive vascular dysfunction and remains a leading cause of cardiovascular morbidity and mortality worldwide. Endothelial dysfunction is an early and critical event in a...
8oxoG:A Is Structurally Accommodated in the Nucleosome Core Particle, Yet Inaccessible to MUTYH-Initiated DNA Repair [0.03%]
8-羟基鸟嘌呤A可在核小体核心颗粒中容纳，但仍无法启动DNA修复的MUTYH酶访问
Abigayle F Vito,Justin A Ling,Julia C Ferrara et al.
Abigayle F Vito et al.
Eukaryotic genomic DNA is packaged into chromatin as nucleosomes, where it remains susceptible to reactive oxygen species (ROS) that generate the mutagenic lesion 8-oxo-7,8-dihydroguanine (8oxoG). While 8-oxoguanine DNA glycosylase 1 (OGG1)...
FGF21 and SHBG as Putative Hepatic Axes in Maternal Metabolic Adaptation: A Hypothetical Framework for Postpartum Insulin Sensitivity Restoration [0.03%]
母体代谢调节中的FGF21和SHBG潜在肝轴在产后胰岛素敏感性恢复的假设框架
Kornelia Purc-Bandurko,Katarzyna Trojnar,Angelika Masiarz et al.
Kornelia Purc-Bandurko et al.
Pregnancy is a physiological state of transient, reversible insulin resistance accompanied by major adaptations in glucose and lipid metabolism. Although placental hormones are key drivers of gestational insulin resistance, the mechanisms u...
Altered Iron Metabolism in Dogs with Naturally Occurring Cardiac Disease [0.03%]
自然发生的铁代谢异常与犬心脏疾病的关系研究
Carolina Frizzo-Ramos,Pavlos Doulidis,Ursula S Kolm et al.
Carolina Frizzo-Ramos et al.
Cardiac disease represents a major cause of morbidity and mortality in dogs. In human cardiology, iron deficiency is a highly prevalent and clinically relevant comorbidity, contributing to exercise intolerance, symptom burden, and impaired ...
Osteopontin in the Central Nervous System: Roles in Development, Injury, Neurodegeneration, and Neuro-Oncology [0.03%]
中枢神经系统的骨桥蛋白：在发育、损伤、神经退行性疾病和神经肿瘤学中的作用
Wei Zhang,Xianji Wei,Minyou Chen et al.
Wei Zhang et al.
Osteopontin (OPN), encoded by the SPP1/Spp1 gene, is increasingly recognized as an extracellular matrix-associated immunoregulatory molecule in the central nervous system (CNS). In CNS-related contexts, OPN does not act as a uniformly prote...
miR-132-y Targets YAP1 and Modulates Sertoli Cell Viability-Associated Transcriptional Responses in Southdown × Hu F1 Sheep [0.03%]
miR-132-y靶向YAP1并调节南_down×胡羊杂交_f1精子细胞存活相关的转录反应
Binpeng Xi,Zengkui Lu,Rui Zhang et al.
Binpeng Xi et al.
Sertoli cells are essential for testicular development and spermatogenesis, but the post-transcriptional mechanisms regulating their function in sheep remain incompletely understood. This study investigated the regulatory relationship betwe...