Beyond the BMI Paradox: Unraveling the Cellular and Molecular Determinants of Metabolic Health in Obesity [0.03%]
超越BMI悖论：解开肥胖症代谢健康细胞和分子决定因素之谜
Kyoichiro Tsuchiya,Takahiro Tsutsumi
Kyoichiro Tsuchiya
Obesity has traditionally been considered a major risk factor for numerous metabolic disorders and diseases. However, a subset of individuals with obesity, classified as having "metabolically healthy obesity" (MHO), display relatively norma...
Thymol Preserves Spermatogenesis and Androgen Production in Cisplatin-Induced Testicular Toxicity by Modulating Ferritinophagy, Oxidative Stress, and the Keap1/Nrf2/HO-1 Pathway [0.03%]
百里酚通过调节铁死亡自噬、氧化应激和Keap1/Nrf2/HO-1信号通路来保护顺铂诱导的生精毒性和雄激素生成损伤
Amira M Badr,Sheka Aloyouni,Yasmin Mahran et al.
Amira M Badr et al.
Cisplatin (CDDP) is a widely used chemotherapeutic agent, but its off-target toxicity, including testicular damage, limits clinical use. Bioactive compounds may help mitigate chemotherapy-induced reproductive toxicity. This study investigat...
Peroxisome Proliferator-Activated Receptors (PPARs): A Themed Issue in Honor of Prof. Walter Wahli [0.03%]
纪念Walter Wahli教授的专刊——过氧化物酶体增殖激活受体(PPARs)
Hervé Guillou,Manuel Vázquez-Carrera
Hervé Guillou
It is with great pleasure that we introduce this Special Issue dedicated to Peroxisome Proliferator-Activated Receptors (PPARs), honoring the pioneering contributions of Professor Walter Wahli [...].
Label-Free and Ultrasensitive APE1 Detection Based on Hybridization Chain Reaction Combined with G-Quadruplex [0.03%]
基于杂交链式反应结合G-四联体的免标记及超灵敏APE1检测方法
Yarong Zhang,Hongyan Ma,Zhenyao Gao et al.
Yarong Zhang et al.
Apurinic/apyrimidinic endonuclease 1 (APE1) selectively cleaves the apurinic/apyrimidinic site (AP site) in DNA, playing a critical role in base excision repair and genomic stability maintenance. Aberrant APE1 expression has been linked to ...
Multi-Temperature Crystallography of S-Adenosylmethionine Decarboxylase Observes Dynamic Loop Motions [0.03%]
多温度晶体学观测到S-腺苷甲硫氨酸脱羧酶的动态环状运动
Jenitha R Patel,Timothy J Bonzon,Timothy F Bakht et al.
Jenitha R Patel et al.
S-adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the polyamine biosynthesis pathway and plays a key role in the synthesis of the polyamines spermidine and spermine, polycationic alkylamines that are present in millimo...
Global Fibrosis Burden and a Transcriptional Biomarker-Based Strategy for Early Detection in Resource-Limited Settings [0.03%]
全球纤维化负担及资源有限条件下的早期检测转录生物标志物策略
Qinqin Deng,Longjiang Wu,Chenlu Zhang et al.
Qinqin Deng et al.
Fibrotic diseases contribute to nearly half of all deaths in industrialized countries, yet effective early detection strategies remain lacking, particularly in low-resource settings. This study aimed to quantify the global burden of fibrosi...
Multiple Applications of Nanomaterials in the Diagnosis and Treatment of Hemorrhagic Stroke [0.03%]
纳米材料在出血性卒中的诊断和治疗中的多种应用
Boyao Yuan,Taotao Jiang,Jingjing Han et al.
Boyao Yuan et al.
Hemorrhagic stroke is a severe cerebrovascular disease with a high rate of disability and mortality. Its complex pathological mechanisms, such as blood-brain barrier damage, neuroinflammation, and oxidative stress, along with the restrictiv...
Association of Inflammatory and Oxidative Stress Biomarkers Adjusted by Personal, Psychological, Biochemical, Anthropometric, and Physiological Variables with Global DNA Methylation in a Sample of Mexican Individuals [0.03%]
调整个人、心理、生化、人体测量和生理变量的炎症和氧化应激生物标志物与墨西哥人全球DNA甲基化的关联性研究
Heriberto Jacobo-Cuevas,Jorge Ivan Gamez-Nava,Saúl Ramírez-De Los Santos et al.
Heriberto Jacobo-Cuevas et al.
Global DNA methylation has been associated with numerous traits and conditions; however, its relationship with inflammation and oxidative stress biomarkers has not been fully elucidated. The objective of this study is to determine the corre...
Serdar M Dursun,Leman H Dursun,Glen B Baker
Serdar M Dursun
Most amino acids contain a chiral center and thus, can exist as L- and D-isomers. For many years, it was thought that only the L-isomers were present in mammals. However, in recent decades it has been demonstrated that D-isomers are also pr...
Anatomical, Physiological, and Transcriptome Analyses Revealing Pod Shattering of Medicago ruthenica Associated with Pericarp Lignin Biosynthesis [0.03%]
基于果皮木质素生物合成的大豆胞分离相关的大豆异株的解剖学、生理学和转录组分析
Lin Zhu,Maowei Guo,Zhiyong Li et al.
Lin Zhu et al.
Background: Medicago ruthenica, a perennial legume forage valuable for ecological restoration and improved breeding, suffers significant harvest losses due to pod shattering. Pod shattering is a trait not only linked to not only pod ventral...