Sequence-Anchored Shared Tumor-Specific Epitopes for Pre-Manufactured HLA-Matched mRNA Cancer Vaccine Libraries: A Pan-Cancer Framework [0.03%]
基于序列的共享肿瘤特异性表位用于预生产的HLA匹配型mRNA癌症疫苗库：一种泛癌框架
Sarfaraz K Niazi
Sarfaraz K Niazi
A single vaccine cannot prevent or treat all cancers; however, recurrent tumor-specific epitopes may facilitate the development of pre-manufactured, HLA-matched mRNA vaccines tailored for specific molecular subgroups. We define the shared t...
High Corticosterone Affects Somite Development During Early Avian Embryogenesis [0.03%]
高皮质酮在早期禽类胚胎发育中的作用
Deeksha Aarti Nursimulu,Anita Heiß,Jiazhao Song et al.
Deeksha Aarti Nursimulu et al.
Maternal stress has been associated with altered embryonic and fetal development, yet the mechanisms by which stress hormones influence early developmental processes remain poorly understood. Early embryogenesis is particularly sensitive be...
Reference Genes for Circadian Profiling of Core Clock Genes in the Blood of Obstructive Sleep Apnea Patients [0.03%]
用于阻塞性睡眠呼吸暂停患者血液中核心生物钟基因昼夜节律分析的参考基因
Katarina Nahtigal,Ana Halužan Vasle,Tinkara Kreft et al.
Katarina Nahtigal et al.
Circadian rhythm disruptions are increasingly recognized in disorders such as obstructive sleep apnea (OSA), yet analysis of 24 h gene expression patterns remains challenging due to the lack of reliable reference genes for normalization. Ev...
Myostatin Orchestrates miR-124-Mediated Epigenetic Silencing of ITGB1 to Suppress Skeletal Muscle Growth [0.03%]
肌营养不良蛋白通过miR-124介导的ITGB1表观遗传沉默抑制骨骼肌生长
Qi Chen,Xianyu Wen,Mengting Li et al.
Qi Chen et al.
Although myostatin is a well-established inhibitor of myogenesis, its downstream mediators remain poorly characterized. This study identified integrin β1 (ITGB1), an integrin family member, as a novel mediator in myostatin signaling. Our r...
Cyclodextrin-Based Delivery Systems in Cosmeceuticals: Current Advances and Future Perspectives [0.03%]
化妆品中环糊精基递送系统：目前的研究进展和未来展望
Catarina Amaro,Tomasz Kowalczyk,Laurent Picot et al.
Catarina Amaro et al.
Cyclodextrins are cyclic carbohydrates capable of forming inclusion complexes with a wide range of molecules, thereby improving their solubility, stability, and bioavailability. Traditionally, cyclodextrins have been extensively applied in ...
S-Adenosyl-L-Homocysteine Hydrolase (SAHH): Structure, Function, and Applications [0.03%]
腺苷蛋氨酸脱羧酶（SAMHD1）的结构、功能及应用展望
Jinsha Huang,Qingpu Chen,Haihua He et al.
Jinsha Huang et al.
S-adenosyl-L-homocysteine hydrolase (SAHH) is an evolutionarily conserved enzyme present in eukaryotes, bacteria, and archaea. As the rate-limiting enzyme in the methionine cycle, it catalyzes the reversible hydrolysis of S-adenosyl-L-homoc...
Effects of Cigarette Smoking on Oxidative Stress, DNA Damage, Immunological Profile, Viral Susceptibility, and Survival in Patients with Chronic Obstructive Pulmonary Disease [0.03%]
吸烟对慢性阻塞性肺疾病患者氧化应激、DNA损伤、免疫状况、病毒易感性和生存率的影响
Antonio de Iure,Laura Vitiello,Stefania Proietti et al.
Antonio de Iure et al.
Background: Cigarette smoking promotes persistent systemic alterations in COPD, yet the interplay among genetic susceptibility, oxidative stress, immune dysregulation, impaired control of persistent viral replication, and...
Observational Study
Biomolecules. 2026 Jul 10;16(7):1009. DOI:10.3390/biom16071009 2026
The Inflammaging-Redox-InflammamiR Axis in Metabolic Aging: From Diagnostic Clusters to Integrated Risk Phenotypes [0.03%]
代谢衰老中的炎症-氧化-炎症微RNA轴：从诊断亚型到综合风险表型
Nurzhanyat Ablaikhanova,Ingkar Okhas,Aidos Bolatov et al.
Nurzhanyat Ablaikhanova et al.
Age-associated metabolic dysfunction is commonly defined by abnormalities in adiposity, glucose regulation, lipid metabolism, and blood pressure. Although clinically useful, these criteria do not fully capture the biological heterogeneity t...
Kevin Castillo-Mendieta,Guillermin Agüero-Chapin,Edgar A Márquez Brazón et al.
Kevin Castillo-Mendieta et al.
Bioactive peptides constitute a highly diverse and therapeutically relevant molecular class, yet their systematic exploration remains challenging because of the vast size, heterogeneity, and fragmented annotation of peptide chemical space. ...
GPX4 in the Tumor Microenvironment: Not Just Inhibiting Ferroptosis, but Immuno-Metabolic Regulation [0.03%]
肿瘤微环境中的GPX4：不仅仅是抑制铁死亡，还有免疫代谢调节
Xinzhe Li,Manxuan Zhang,Zenan Xu et al.
Xinzhe Li et al.
Glutathione peroxidase 4 (GPX4) is canonically viewed as the primary suppressor of ferroptosis, yet its role in the tumor microenvironment (TME) extends far beyond antioxidant catalysis to encompass immuno-metabolic regulation. In this revi...