Postmortem Stability Analysis of Lipids and Polar Metabolites in Human, Rat, and Mouse Brains [0.03%]
人类、大鼠和小鼠脑组织中脂质及极性代谢物的腐败稳定性分析
Marina Zavolskova,Dmitry Senko,Olga Bukato et al.
Marina Zavolskova et al.
Lipids and polar metabolites are emerging as promising indicators of the brain's molecular phenotype in both clinical and fundamental research. However, the impact of postmortem delay on these compounds, unavoidable in human brain studies, ...
Human Stem Cell-Based Embryo Models in Implantation Research: Regulation, Consistency and Potential [0.03%]
基于人类干细胞的胚胎模型在着床研究中的应用：规范、一致性和潜力
Søren Holm
Søren Holm
The use of human stem cell-based embryo models (hSCBEM) in implantation research is developing rapidly. This raises regulatory and ethical issues as these models become more complex and get closer to morphological and functional identity wi...
Optogenetics: A Novel Therapeutic Avenue for Age-Related Macular Degeneration [0.03%]
光遗传学：年龄相关性黄斑变性的新疗法途径研究
Pier Luigi Grenga,Chiara Ciancimino,Alessandro Meduri et al.
Pier Luigi Grenga et al.
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly, characterized by progressive degeneration of the retinal pigment epithelium (RPE) and photoreceptors in the macula. Current treatment opti...
Synthesis and Bioevaluation of Chalcones as Broad-Spectrum Antiviral Compounds Against Single-Stranded RNA Viruses [0.03%]
茋类化合物衍生物对冠状病毒3CL蛋白酶的抑制作用及机制研究
Lorael K M Kirton,Nasser N Yousef,Griffith D Parks et al.
Lorael K M Kirton et al.
Chalcones are flavonoid compounds containing an α,β-unsaturated ketone core that are often found in plants and have diverse biological activities including antiviral activity. For example, chalcone 8o was previously shown to have antivira...
In Situ Synthesis of Bacterial Cellulose-Supported CoAl-Layered Double Hydroxide as a Peroxymonosulfate Activator for Enhancing the Removal of Tetracycline [0.03%]
原位合成细菌纤维素负载CoAl层状双氢氧化物作为过一硫酸盐活化剂高效去除四环素抗生素
Xiuzhi Bai,Yongsheng Du,Zhongxiang Liu et al.
Xiuzhi Bai et al.
This study employed the hydrothermal coprecipitation method to grow CoAl-layered double hydroxide (LDH) onto bacterial cellulose (BC) in situ, successfully preparing the CoAl-LDH@BC composite. This composite was then used to activate peroxy...
The Impact of Glucagon-like Peptide-1 Receptor Agonists on Erectile Function: Friend or Foe? [0.03%]
glucagon-like肽-1受体激动剂对勃起功能的影响：是好是坏？
Dimitris Kounatidis,Natalia G Vallianou,Eleni Rebelos et al.
Dimitris Kounatidis et al.
Erectile dysfunction (ED) is a common yet frequently underrecognized microvascular complication of diabetes, affecting up to three out of four individuals. Key contributing factors include advancing age, long-standing disease duration, and ...
Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum [0.03%]
联合辐射：跨辐射谱的混合辐射生物效应
Orfeas Parousis-Paraskevas,Angeliki Gkikoudi,Amer Al-Qaaod et al.
Orfeas Parousis-Paraskevas et al.
Combined radiation exposures-pairings of ionizing and non-ionizing radiation-are increasingly relevant in medical, spaceflight, and environmental contexts. This systematic review evaluates their radiobiological effects and therapeutic appli...
Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target [0.03%]
烟酰胺N-甲基转移酶在心血管疾病中扮演代谢调节及新兴治疗靶点的作用
Jawaria,Yusra Zarlashat,Márton Philippovich et al.
Jawaria et al.
Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide, arising from complex interactions among metabolic, genetic, and environmental factors. Nicotinamide N-methyltransferase (NNMT) has recently emerged a...
A Novel Culture System for Inhibiting In Vitro Differentiation of Ovine Granulosa Cells [0.03%]
一种新的培养体系可抑制卵泡颗粒细胞体外分化
Yufen Zhao,Haijiang Liu,Zhe Mu et al.
Yufen Zhao et al.
The in vitro granulosa cell (GC) model presents a valuable tool to explore antral follicle development. A full understanding of the reasons and blocking methods that occur during in vitro luteinization of sheep GCs, stimulated by serum cult...
Molecular and Computational Studies Reveal That Per- and Polyfluoroalkyl Substances Can Impair Protamine-DNA Interaction, Potentially Inducing DNA Damage [0.03%]
分子和计算研究表明全氟和多氟烷基物质可干扰protamine-DNA相互作用，从而可能诱导DNA损伤
Federica Musella,Maria Grazia Guarnieri,Simona Amore et al.
Federica Musella et al.
Interactions between protamines and DNA are essential for the correct structure of human sperm chromatin. Reproductive health can be adversely affected by environmental pollutants like per- and polyfluoroalkyl substances (PFAS). We previous...