The Content and Location of 3- O-Sulfated Glucosamine Enable Differentiation of Ovine, Bovine and Porcine Heparins [0.03%]
羊肝素、牛肝素和猪肝素中3-O硫酸氨基葡萄糖的结构与位置差异性分析
Arianna Somma,Elena Urso,Michela Parafioriti et al.
Arianna Somma et al.
Heparin, the naturally occurring, highly sulfated glycosaminoglycan drug, acts as a regulator of diverse biological processes by interacting with diverse specific proteins through a variety of sulfated structural motifs with varying degrees...
Effects of Red Onion Peel Extracts on Oxidative Stress in Caenorhabditis elegans [0.03%]
红 onion皮提取物对秀丽隐杆线虫氧化压力的影响
Héctor Palacios,Miguel Ángel Rodríguez,Nerea Abasolo et al.
Héctor Palacios et al.
Polyphenols are natural compounds with antioxidant properties that help prevent chronic diseases. Red onion (Allium cepa) peels are an underutilized source of polyphenols, offering a sustainable opportunity for the valorization of agricultu...
The ZFP36 Family as a Post-Transcriptional Immune Checkpoint in Immunity and Disease: Molecular Mechanisms and Functional Implications [0.03%]
ZFP36家族作为转录后免疫检查点在免疫和疾病中的作用：分子机制与功能意义
Yuting Yang,Wenhao Zhong,Qiang Huang et al.
Yuting Yang et al.
The zinc finger protein 36 (ZFP36) family, including ZFP36/tristetraprolin (TTP), ZFP36 CCCH-type-like 1 (ZFP36L1), and ZFP36 CCCH-type-like 2 (ZFP36L2), consists of conserved CCCH-type tandem zinc-finger RNA-binding proteins. These protein...
Structure-Based Screening of Antiviral Candidates Against Infectious Spleen and Kidney Necrosis Virus (ISKNV) Using Molecular Docking and In Vitro Evaluation [0.03%]
基于结构的抗感染脾肾坏死病毒(ISKNV)分子对接和体外试验筛选活性化合物研究
Eun-Jin Baek,Hyun-Deok Choi,Ye-Jin Jeong et al.
Eun-Jin Baek et al.
Infectious spleen and kidney necrosis virus (ISKNV) causes systemic infections and high mortality in various freshwater and marine fish species, posing a serious threat to aquaculture and ornamental fish industries. In this study, 72 antivi...
Physiology and Multi-Omics Provide Insights into Sperm Activation and Movement in Euryhaline Spotted Seabass (Lateolabrax maculatus) [0.03%]
生理学和多组学为副斑乌塘鱼（Lateolabrax maculatus）全盐性精子活化和运动提供见解
Qinghua Wang,Yuxin Zhang,Weiwei Zhang et al.
Qinghua Wang et al.
Sperm activation and movement are pivotal determinants of fertilization success in teleosts, yet the molecular mechanisms in euryhaline species remain largely unresolved. Here, we integrated physiology and multi-omics to elucidate the osmol...
Targeting the RSV and hMPV L Protein: Cryo-EM and Structure-Based Approaches to Antiviral Drug Discovery [0.03%]
针对RSV和hMPV L蛋白的靶向：基于冷冻电镜和结构的抗病毒药物发现方法
Yoon Ho Park,Rana Kim,Kun-Ho Song et al.
Yoon Ho Park et al.
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), members of the family Pneumoviridae, represent a foremost global cause of acute lower respiratory tract infection in infants, young children, the elderly, and immunocomprom...
Lumeng Zhang,Jun He
Lumeng Zhang
Functional imaging has become an important approach for evaluating tumor physiology in vivo beyond morphologic assessment. Radiotracers used for cancer imaging are designed to mimic endogenous substrates or substrate analogues, and their ac...
CD36 as a Context-Dependent Regulator of Metabolic Switching in Acute and Chronic Hypoxia [0.03%]
急性缺氧和慢性缺氧下CD36通过不同的信号途径调控代谢转换中的作用机制研究
Mihaela R Popescu,Anca M Panaitescu,Laura Cristina Ceafalan et al.
Mihaela R Popescu et al.
CD36 is a multifunctional scavenger receptor involved in long-chain fatty acid (LCFA) uptake, binding of oxidized lipids, and interactions with extracellular matrix proteins such as thrombospondin-1. Through association with Src family kina...
Maternal Metformin Exposure Induces Gut Microbial Shifts in Non-Diabetic Dams and Sex-Stratified Changes in Mouse Offspring [0.03%]
母体服用二甲双胍暴露诱导非糖尿病大鼠肠道微生物群变化并导致小鼠后代性别分化的改变
Dat Da Ly,Kate Phuong-Nguyen,Trang T T Truong et al.
Dat Da Ly et al.
Beyond being one of the most widely prescribed medications for type 2 diabetes, metformin has been increasingly used during pregnancy for gestational diabetes and polyendocrine metabolic ovarian syndrome. While it is considered safe for pre...
Molecular Mechanisms and Targeted Therapies of PTPN2 in Metabolic Diseases: A Review [0.03%]
PTPN2在代谢性疾病中的分子机制和靶向治疗：综述
Yue Yuan,Jing Xie,Mo Wang et al.
Yue Yuan et al.
Metabolic disorders encompass a spectrum of pathologies driven by the dysregulation of systemic metabolic homeostasis. Their escalating global prevalence has positioned these conditions at the forefront of contemporary biomedical research. ...