Haochuan You,Yixiang Zhao,Xiuyuan Wang et al.
Haochuan You et al.
Skeletal homeostasis relies on coordinated interactions among osteoblasts, osteoclasts, osteocytes, chondrocytes, and bone marrow stromal cells. Disruption of this balance contributes to the development of osteoporosis, osteoarthritis, impa...
Integrated Experimental and Preliminary In Silico Study of Myrtenyl Dihydrocaffeate: Biocatalytic Synthesis Optimization, Antioxidant Evaluation, and Oxidative Stabilization of Rapeseed Oil [0.03%]
薄荷基二氢咖啡酸酯的集成实验和初步计算研究：生物催化合成优化、抗氧化评价及油菜籽油的氧化稳定化
Bartłomiej Zieniuk,Jakub Gielmuda,Chimaobi James Ononamadu
Bartłomiej Zieniuk
Dihydrocaffeic acid (DHCA) is a naturally occurring phenolic acid with recognized antioxidant and biological properties. However, its relatively high polarity limits its applicability in lipid-based systems. In this study, myrtenyl dihydroc...
Inflammation-Associated Transcriptional Remodeling of Antioxidant and Stress Signaling Pathways in First-Trimester Placenta in Maternal Overweight and Obesity [0.03%]
母体超重和肥胖对早期胎盘抗氧化和应激信号通路的转录重塑的影响
Denise Hoch,Alejandro Majali-Martinez,Francisco Algaba Chueca et al.
Denise Hoch et al.
The first trimester (FT) of pregnancy is characterized by rapid placental growth and differentiation, rendering this period sensitive to maternal metabolic influences. Maternal obesity is associated with chronic low-grade inflammation and a...
Beyond Equilibrium Refractive-Index Shifts: Dynamical Information Encoded in Sensorgrams [0.03%]
平衡折射率变化之外：传感器图中编码的动力学信息
Giuseppina Simone
Giuseppina Simone
Disordered Ag-nanowire localized surface plasmon resonance sensorgrams for glycated hemoglobin (HbA1c) detection exhibit reproducible multi-component temporal structures that cannot be fully explained within conventional equilibrium refract...
Secretion Patterns of Leptin: A Key Component in the Regulation of Energy Homeostasis and Its Therapeutic Applications [0.03%]
促瘦素分泌模式及其在能量平衡调节和治疗中的作用关键因素
Chen Wang,Xianglu Rong
Chen Wang
Leptin is the oldest studied adipokine, and its mechanism of action in the regulation of energy metabolism remains a hot topic of current research. In this paper, we systematically review the progress of clinical and basic research on lepti...
Identification of Potential Biomarkers Associated with Impaired Fatty Acid Oxidation in Aged Skeletal Muscle Using Bioinformatics and Machine Learning Approaches [0.03%]
基于生物信息学和机器学习方法鉴定与衰老骨骼肌脂肪酸氧化障碍相关的潜在生物标志物
Haoyang Gao,Fangjie Yang,Jiabin Wu et al.
Haoyang Gao et al.
Objective: Impaired fatty acid oxidation (FAO) is considered an important metabolic mechanism underlying skeletal muscle aging and sarcopenia; however, the key regulatory molecules involved in this process remain incompletely defined. This ...
From GWAS Signals to Molecular Mechanisms: Explainable AI for Causal Gene Prioritization and Biomolecular Target Interpretation [0.03%]
从GWAS信号到分子机制：用于因果基因优先级排序和生物分子靶点解释的可解释人工智能
Mia Yang Ang,Li Chen,Lanni Song et al.
Mia Yang Ang et al.
Genome-wide association studies (GWAS) have identified thousands of loci associated with complex human diseases. However, the majority of the association signals reside in non-coding regions of the genome, and do not directly reveal the cau...
Heme Oxygenase-1 Contributes to Dampening Proinflammatory Activation in the Human Microglial Cell Line HMC3 and Controls the Transcription Factor IRF5 [0.03%]
血红素氧合酶-1通过抑制转录因子IRF5活化削弱人类小胶质细胞系HMC3的促炎反应
Anna Lisa Furfaro,Paola Mancini,Mario Passalacqua et al.
Anna Lisa Furfaro et al.
Neuroinflammation is recognized as a pivotal factor in promoting neurodegeneration. However, the molecular mechanisms underlying the dysregulation of proinflammatory signaling in microglial cells remain largely elusive. A prominent role has...
Wei Ma,Jinfen Zhang,Hongyu Liao et al.
Wei Ma et al.
The tree shrew is a small mammal characterized by a short gestation period, a relatively short lifespan, and low maintenance costs. It exhibits a close genetic relationship with primates and humans. The tree shrew possesses an eight-layered...
MicroRNA Profiling of the Pathophysiological Mechanisms Underlying Carotid Atherosclerosis Progression [0.03%]
颈动脉粥样硬化进展的病理生理机制的微小核糖核酸谱分析
Katarzyna Prus,Marco Sanvitti,Federico Bilotta
Katarzyna Prus
Carotid atherosclerosis is a major contributor to ischemic stroke, driven by complex interactions between inflammation, lipid metabolism, and vascular dysfunction. MicroRNAs (miRNAs) have emerged as key regulators of the molecular mechanism...