Natural Compounds as Modulators of Ferroptosis: Mechanistic Insights and Therapeutic Prospects in Breast Cancer [0.03%]
天然化合物作为铁死亡调节剂在乳腺癌中的机制洞察和治疗前景研究
Haotong He,Haoyang Yu,Hefeng Zhou et al.
Haotong He et al.
Breast cancer is the most prevalent malignant tumor in women. However, its clinical management is severely hindered by three interconnected challenges that limit long-term survival: treatment resistance, metastatic dissemination, and immuno...
Single-Vesicle Molecular Profiling by dSTORM Imaging in a Liquid Biopsy Assay Predicts Early Relapse in Colorectal Cancer [0.03%]
单 vesicle 分子分型在液体活检中通过 dSTORM 成像预测结直肠癌的早期复发
Gabriele Raciti,Giulia Cavallaro,Raffaella Giuffrida et al.
Gabriele Raciti et al.
Background and objectives: Colorectal cancer (CRC) is the third most diagnosed tumor type and the second leading cause of cancer-related mortality. Despite recent improvements in the clinical management of CRC patients bo...
Gene Duplication, Translocation, and Molecular Evolution of Dmrt1 and Related Sex-Determining Genes in Anurans [0.03%]
两栖类Dmrt1及相关性别决定基因的基因复制、易位及分子进化
Sagar S Shinde,Paris Veltsos,Wen-Juan Ma
Sagar S Shinde
Sex determination, the developmental process that directs embryos toward male or female fates, is controlled by master sex-determining genes whose origins and evolutionary dynamics remain poorly understood outside of a few model systems. In...
Isoniazid-Derived Hydrazones Featuring Piperazine/Piperidine Rings: Design, Synthesis, and Investigation of Antitubercular Activity [0.03%]
异烟肼衍生物哌嗪/哌啶杂环的设计、合成及抗结核活性研究
Esma Özcan,Siva Krishna Vagolu,Rasoul Tamhaev et al.
Esma Özcan et al.
Isoniazid (isonicotinic acid hydrazide, INH) is a key drug used to treat tuberculosis (TB), which continues to be the world's most lethal infectious disease. Nevertheless, the efficacy of INH has diminished because of the emergence of Mycob...
A Comprehensive Oncological Biomarker Framework Guiding Precision Medicine [0.03%]
精准医学的全面肿瘤生物标志物框架指南
Reza Bayat Mokhtari,Manpreet Sambi,Faezeh Shekari et al.
Reza Bayat Mokhtari et al.
Cancer remains a major cause of mortality worldwide, driving ongoing innovation in therapeutic strategies. Immunotherapy has transformed cancer care by leveraging the immune system to target tumors, but its effectiveness is limited by tumor...
Natural Product-Derived Drugs: Structural Insights into Their Biological Mechanisms [0.03%]
天然产物衍生物药物：结构视角下的生物学机制研究
Yujeong Choi,Younghyun Kim,Hye Joon Boo et al.
Yujeong Choi et al.
Natural product-derived drugs represent a cornerstone of modern pharmacotherapy, with many serving as essential therapeutic agents across diverse medical conditions. Recent advances in structural biology have provided unprecedented insights...
Nature's Synergy: Cellular and Molecular Evaluation of Snail Slime and Its Principal Component, Glycolic Acid, on Keratinocytes, with Preliminary Evidence from Endothelial Cells [0.03%]
天然协同作用——蜗牛 slime 及其主要成分甘醇酸对角质细胞的细胞及分子评估，初步探讨内皮细胞的证据
Muhammad Rashad,Alessia Ricci,Serena Pilato et al.
Muhammad Rashad et al.
Snail slime (SS) is a natural secretion rich in bioactive components such as glycoproteins, hyaluronic acid, glycolic acid (GA), and antimicrobial peptides. GA, a key component of SS, is known for its exfoliative properties. This study inve...
In Vivo Anti-Inflammatory Activity of Lipids Extracted from the Most Abundant Cyanobacterial Strains of the Therapeutic Euganean Thermal Muds [0.03%]
药用埃武阿温泉泥中优势类细菌菌株脂质的体外抗炎活性
Micol Caichiolo,Giuliana d&#x;Ippolito,Angela Grazioso et al.
Micol Caichiolo et al.
Cyanobacteria are a natural source of bioactive compounds increasingly recognized for their anti-inflammatory properties. In the Euganean Thermal District (Italy), thermal muds, used to cure arthro-rheumatic diseases, are prepared using nat...
Cerebrospinal Fluid Erythrocyte Burden Amplifies the Impact of PTAU on Entorhinal Degeneration in Alzheimer's Disease [0.03%]
脑脊液中红细胞负荷加重了PTAU在阿尔茨海默病内侧颞叶变性中的影响
Rafail C Christodoulou,Georgios Vamvouras,Vasileia Petrou et al.
Rafail C Christodoulou et al.
Background: Alzheimer's disease (AD) involves ongoing neurodegeneration, with phosphorylated tau (PTAU) intracellular accumulation closely associated with cortical shrinking. However, not everyone with high PTAU levels sh...
Pharmacokinetics of Novel Crystalline Buntanetap in Mice, Dogs, and Humans [0.03%]
布塔奈普在小鼠、犬和人体内的药代动力学研究
Alexander Morin,Michael Christie,Eve Damiano et al.
Alexander Morin et al.
Buntanetap is an orally bioavailable small molecule that has been shown to improve cognitive function in patients with Alzheimer's and Parkinson's diseases and holds promise for use in other neurodegenerative conditions. Until now, a crysta...