Effects of Amino Acid Point Mutations on the Local Hydrophobicity, Structural Stability, and Conformational Flexibility of P-Glycoprotein [0.03%]
氨基酸点突变对P-糖蛋白的局部疏水性、结构稳定性和构象柔韧性的影响
Alexandra Ioana Năstasie,Adriana Isvoran
Alexandra Ioana Năstasie
P-glycoprotein (P-gp, ABCB1) plays a central role in multidrug resistance and drug pharmacokinetics. In this study, an integrated computational analysis of point amino acid substitutions across the P-gp sequence was performed to evaluate th...
Solvent-Free Mechanochemical Synthesis, Antispasmodic Activity, and Integrated In Silico Mechanistic Analysis of a Dapsone-Derived Phenylaminojuglone [0.03%]
无溶剂机械化学合成、抗痉挛活性及达帕森衍生酚氨基 juglone 的综合计算机辅助机制分析
Ricardo E Zavaleta-Miñano,Elena Mantilla-Rodríguez,Roberto O Ybañez-Julca et al.
Ricardo E Zavaleta-Miñano et al.
The structural hybridization of bioactive quinones is a promising strategy for generating pharmacologically active compounds through sustainable synthetic approaches. This study aimed to synthesize and evaluate a dapsone-derived phenylamino...
Green Fabrication of Keratin Nanoparticles from Yak Horn by Steam Flash Explosion: Structure-Property Evolution [0.03%]
蒸汽爆破法制备牦牛角角蛋白纳米颗粒及其结构性能演变研究
Zhisong Qian,Haiyue Feng,Kun Meng et al.
Zhisong Qian et al.
Yak horn represents a valuable resource for fabricating keratin-derived materials; however, its dense, highly cross-linked protein network resists efficient processing via conventional extraction methods. This study introduces a single-step...
p53-Dependent ENOX2 Downregulation Mediates the Apoptotic Responses to Heteroarene-Fused Anthraquinones in Colon Cancer Cells [0.03%]
P53依赖的ENOX2下调介导了异芳香环并蒽醌化合物对结肠癌细胞凋亡反应的影响
Chien-Yu Chen,Alexander S Tikhomirov,Yih-Farng Liou et al.
Chien-Yu Chen et al.
Anthraquinone-based intercalating compounds, such as doxorubicin and mitoxantrone, have long been used clinically due to their ability to induce DNA damage. More recently, heteroarene-fused anthraquinones have been developed to further enha...
Chemogenetic Activation of LC Noradrenergic Afferents Facilitates Cerebellar CF-PC LTD via Presynaptic α2A-AR/CDK5/PKA Signaling [0.03%]
化学遗传活化LC去甲肾上腺素能投射促进 cerebellar CF-PC长时程抑制造备突触α2A-AR/CDK5/PKA信号转导
Xu-Dong Zhang,Ying-Han Xu,Wang-Tong Wu et al.
Xu-Dong Zhang et al.
Cerebellar climbing fiber-Purkinje cell (CF-PC) long-term depression (LTD) plays a critical role in motor learning and is modulated by locus coeruleus (LC) noradrenergic afferents via distinct adrenergic receptor (AR) subtypes. Nevertheless...
Tyrosinase-Mediated Oxidation of Endocannabinoid and Endovanilloid N-Arachidonoyl Dopamine and N-Arachidonoyl Tyrosine [0.03%]
酪氨酸酶介导的大麻素和vanilloid类物质N-arachidonoyl多巴胺及N-arachidonoyl酪氨酸的氧化反应
Alessia Mariano,Davide Laurenti,Antonio Francioso et al.
Alessia Mariano et al.
Endocannabinoids are lipid mediators consisting of esters, amides and ethers of long-chain polyunsaturated fatty acids. In this work, attention was focused on N-arachidonoyl tyrosine (NA-Tyr) and N-arachidonoyl dopamine (NADA), the amides o...
Proteoglycans as Molecular Regulators of Bone Metastasis: Extracellular Matrix Remodeling, Tumor-Bone Crosstalk, Dormancy, and Therapeutic Opportunities [0.03%]
糖蛋白作为骨转移的分子调节器：细胞外基质重塑、肿瘤-骨骼相互作用、休眠和治疗机会
Zoila Mora Guzmán,Ibzan Jahzeel Salvador Ibarra,Patricia Juárez et al.
Zoila Mora Guzmán et al.
Background: Bone metastasis is a frequent and debilitating complication of advanced cancer, particularly in breast and prostate cancer, and is driven by complex interactions among tumor cells, bone-resident cells, immune populations, vascul...
Intercalated Motifs Contribute to Transcription Regulation in an Acidosis Model [0.03%]
酸中毒模型中插入式的调控模体对转录的调节作用
Varvara Sapozhnikova,Ekaterina Knizhnik,Dmitriy Shirokov et al.
Varvara Sapozhnikova et al.
The formation and function of intercalated motifs (iMs) in cytosine-rich regions of the human genome have long been debated. While these pH-sensitive structures are unlikely to govern gene expression in normal tissues, their contribution to...
Abdul Wahid,Md Tariqul Islam,Md Sohel Rana et al.
Abdul Wahid et al.
Hypertension-induced vascular remodeling is a major contributor to cardiovascular morbidity and is characterized by endothelial dysfunction, vascular smooth muscle cell phenotypic switching, fibrosis, and inflammation. Sirtuin 3 (SIRT3), a ...
Inorganic Polyphosphate in Hematolymphoid Malignancies: Biological Rationale and Emerging Research Gaps [0.03%]
无机多磷酸盐在血液淋巴系统恶性肿瘤中的生物学原理和新兴研究缺口
Francisco García-Domínguez,Cecilia Fernandez-Ponce,Carlota Salb-Pernas et al.
Francisco García-Domínguez et al.
Inorganic polyphosphates (polyP) are linear phosphate polymers that play essential functions in human physiology, such as coagulation and inflammation. Despite their recognized participation in solid tumor progression, there are few data on...