Activin A Secreted by Cancer-Associated Fibroblasts Reduces the Sensitivity of Breast Cancer Cells to Ixazomib via Inhibition of Proteasome Activity [0.03%]
癌相关成纤维细胞分泌的活化素A通过抑制蛋白酶体活性降低乳腺癌细胞对伊沙佐米的敏感性
Shuaiming Geng,Siyao Liu,He Liu et al.
Shuaiming Geng et al.
Breast cancer (BC) remains a leading cause of cancer-related mortality among women globally, and the role of cancer-associated fibroblasts (CAFs) in promoting BC progression is well established. Ixazomib, a proteasome inhibitor approved for...
Plasminogen Activator Inhibitor-1 in Skin Malignancies: Therapeutic Implications of Its Inhibition [0.03%]
皮肤恶性肿瘤中的纤溶酶原激活物抑制剂-1及其抑制的治疗意义
Taku Fujimura,Yusuke Muto,Yoshihide Asano
Taku Fujimura
Plasminogen activator inhibitor-1 (PAI-1), a key regulator of fibrinolysis, has emerged as a critical stromal factor that contributes to tumor progression in various malignancies, including skin cancers. Beyond its classical role in inhibit...
The Role of Reactive Oxygen Species in Lung Cancer Development: Nanomedicine as a Therapeutic Strategy [0.03%]
活性氧在肺癌发生发展中的作用及纳米药物的治疗策略
Manuel Olazábal-Morán,Elena Pérez,Adrián Esteban-Arranz et al.
Manuel Olazábal-Morán et al.
Lung cancer remains a leading cause of mortality worldwide, driven by increased tobacco use, industrialization, and air pollution. Despite advancements in diagnostics and treatments, effective therapies are still lacking. Reactive oxygen sp...
Coming Clean and Avoiding Bubble Trouble-Using Detergents Wisely in the Purification of Membrane Proteins for Cryo-EM Studies [0.03%]
坦诚相见，避免“泡沫”困扰——膜蛋白冷冻电镜研究中洗涤剂的合理应用
Bowen Chen,Peter Harrison,Vasileios Kargas et al.
Bowen Chen et al.
Detergent solubilisation remains the most commonly used but potentially problematic method to extract membrane proteins from lipid bilayers for Cryo-EM studies. Although recent advances have introduced excellent alternatives-such as amphipo...
PARP1 and PARG Are the Draft Horses for Polycomb-Trithorax Chromatin Regulator Machinery [0.03%]
聚腺苷二磷酸核糖聚合酶1和聚腺苷二磷酸核糖糖基转移酶是染色质调节机器Polycomb-Trithorax的主力成员
Guillaume Bordet,Alexei V Tulin
Guillaume Bordet
During tissue differentiation, gene expression patterns are committed to the epigenetic cellular memory machinery, including Polycomb and Trithorax groups (PcG and TrxG), which label chromatin with repressive or active histone marks. Histon...
Strand Displacement Chain Reaction (SDCR): New Hybrid Amplification Technique for Fast and Sensitive Detection of Genetic Materials [0.03%]
链置换连锁反应(SDCR)：用于快速灵敏地检测遗传物质的新杂交放大技术
Evgeniya V Smirnova,Ekaterina V Barsova,Dmitriy A Varlamov et al.
Evgeniya V Smirnova et al.
Nucleic acid amplification methods are widely used in science, medicine and forensics for molecular biological assays and for the detection of genetic material. The newly developed strand displacement chain reaction (SDCR) method is a hybri...
Pharmacological and Therapeutic Potential of Chrysopogon zizanioides (Vetiver): A Comprehensive Review of Its Medicinal Applications and Future Prospects [0.03%]
香附子草（ Vetiver）的药理和治疗潜力：对其医药应用和未来前景进行全面回顾
Conjeevaram J Gunasekar,Amin F Majdalawieh,Imad A Abu-Yousef et al.
Conjeevaram J Gunasekar et al.
Chrysopogon zizanioides (Linn.) Nash, commonly known as vetiver, has been an integral component of traditional medicinal systems across India and Asia for centuries. The roots and essential oils of this aromatic grass have been widely utili...
Dual Perspectives on Peptide-Zinc Complexation: Highlighting Aquatic Sources While Contextualizing Other Natural Origins [0.03%]
肽-锌配位的双重视角：突出水生来源并结合其他天然来源进行分析
Lingyu Han,Nuo Dong,Jixin Yang et al.
Lingyu Han et al.
Zinc is an essential mineral for the body, with chelated zinc valued for its superior absorption efficiency and bioavailability. This review systematically examines peptide-zinc interactions, covering fundamental concepts, historical evolut...
Overview of Proteomic Analysis of Amyloid Plaques and Neurofibrillary Tangles in Alzheimer's Disease [0.03%]
阿尔茨海默病淀粉样斑块和神经纤维缠结的蛋白质组分析概述
Amber Grewal,Simran Raikundalia,Joseph Zaia et al.
Amber Grewal et al.
In this review, we describe the methods used for the extraction and mass spectrometry proteomics analysis of amyloid plaques and neurofibrillary tangles (NFTs), the two primary pathological hallmarks of Alzheimer's disease (AD). We also pro...
Novel Animal Models for Multiple Sclerosis: R-Ras GTPases in Myelin Pathophysiology [0.03%]
新型动物模型与多发性硬化症的关系：R-Ras GTP酶与髓鞘病理生理学之间的联系
Gema M Esteban-Ortega,Gonzalo Garcia-Martin,Beatriz Cubelos
Gema M Esteban-Ortega
Demyelinating diseases, such as multiple sclerosis, involve oligodendrocyte death, myelin loss, and neuronal death. These processes have been extensively studied, and a causal relationship has been demonstrated between them: destruction of ...