PFAS Exposure and Metabolic Disorders: Mechanistic Insights into Lipid and Glucose Homeostasis [0.03%]
PFAS暴露与代谢紊乱：脂质和葡萄糖稳态的机制见解
Xinyi Chen,Weijing Wen,Simeng Gu et al.
Xinyi Chen et al.
Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic fluorinated chemicals characterized by high environmental persistence and widespread occurrence, which have attracted increasing attention due to their potential adverse ef...
Role of Endogenous Myoglobin in Anthracycline Response in Breast Cancer [0.03%]
乳腺癌中内源性肌红蛋白在蒽环类药物响应中的作用
Ilona Rybinska,Andreas Petry,Thomas Hankeln et al.
Ilona Rybinska et al.
Anthracyclines such as doxorubicin (DOX) remain central components of breast cancer (BC) chemotherapy, although their efficacy is frequently limited by drug resistance. Myoglobin (MB), an oxygen-binding heme protein expressed in breast tumo...
Analytical Methods and Application of Single-Cell and Single-Nucleus Transcriptomics in the Study of Ischemic Stroke [0.03%]
单细胞和单核转录组分析技术在缺血性脑卒中研究中的应用及挑战
Changqing Mu,Yuchuan Ding,Alexander Weiss et al.
Changqing Mu et al.
Background: Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, with complex and heterogeneous pathophysiological processes. Single-cell and single-nucleus RNA sequencing (sc/snRNA-seq...
Shrinking of Extracellular Space During Metabolic Stress Accelerates Amyloid-β Aggregation [0.03%]
代谢压力下细胞外空间缩小可加速淀粉样蛋白-β聚集
Laura F De Oliveira,Kanchana Karunarathne,Dalton Zona et al.
Laura F De Oliveira et al.
Pathological states associated with metabolic stress, such as traumatic brain injury (TBI), hypoxia, ischemic stroke, and migraine, are considered elevated risk factors for developing Alzheimer's disease (AD). However, the mechanism underly...
Polysaccharide-Based Approaches for Inflammation Treatment: Anti-Inflammatory Mechanisms, Delivery Approaches and Translational Prospects [0.03%]
基于多糖的抗炎策略：抗炎机制、递送方式及转化前景
Xiaoyu Ren,Yuan Zhou,Fei Liu et al.
Xiaoyu Ren et al.
Inflammation is a physiological response of the body to infection and tissue damage; dysregulated inflammatory signaling can cause the initiation and aggravation of a variety of chronic diseases. Although anti-inflammatory drugs have been c...
From Unmet Medical Need to Drug Candidate: A Translational Therapeutic Development Roadmap Illustrated by Dual-Payload Antibody-Drug Conjugates [0.03%]
从临床需求出发发现候选药物——基于双负载抗体偶联药物的转化型新药研发路线图
Takeshi Honda,Gui-Dong Zhu
Takeshi Honda
Transformative therapeutic innovation should not begin with a molecule-or even a molecular target. It should begin with a clearly defined unmet clinical need. Here, we present a seven-step Translational Therapeutic Development Roadmap that ...
ENO1 as an Immunoregulatory Hub in Cancer: Mechanisms and Translational Implications [0.03%]
癌症中的免疫调节枢纽ENO1：机制与转化意义
Giovanni Perconti,Angela Bonura,Patrizia Rubino et al.
Giovanni Perconti et al.
Alpha-enolase (ENO1) is a multifunctional protein frequently overexpressed in solid tumors, where elevated levels are associated with aggressive behavior and poor prognosis. Beyond its canonical glycolytic role, ENO1 participates in immunor...
AUKAT: Conditional VAE-Driven Augmentation and Neural Modeling of Enzyme Turnover Numbers [0.03%]
基于条件VAE的酶周转数增强和神经网络建模(AUKAT)
Mengmeng Liu,Xialong Ni,Michal Brylinski
Mengmeng Liu
Accurate prediction of enzyme turnover numbers (kcat) is essential for applications in systems biology, metabolic engineering, and drug discovery, yet remains challenging due to the limited availability and uneven distribution of experiment...
The Role of AP-1 in Cancer: Regulation, Tumor Microenvironment and Therapeutic Targeting [0.03%]
AP-1在癌症中的作用：调节、肿瘤微环境和治疗靶点
Maria A Katsianou,Dimitrios Vrachas,Christos Adamopoulos
Maria A Katsianou
The activator protein-1 (AP-1) transcription factor is a regulatory dimeric transcription factor complex, that responds to a wide range of intracellular and extracellular stimuli and controls gene expression involved in tumor initiation and...
Expression of Rate-Limiting Enzymes of Melatonin Synthesis in Several Extrapineal Organs During Pregnancy in Ewes [0.03%]
母羊怀孕期间几种非松果体器官中合成褪黑素限速酶的表达
Yanshu Xu,Haozhe Hou,Yang Yang et al.
Yanshu Xu et al.
Melatonin is not only produced by the pineal gland but is also synthesized in extrapineal organs. It plays a key role in antioxidant defense and immune regulation during pregnancy. Two key rate-limiting enzymes are involved in the melatonin...