Proteomics Approaches for Discovering Novel Protein Biomarkers in Inflammatory Bowel Disease-Related Cancer [0.03%]
炎症性肠病相关癌症中用于发现新型蛋白质生物标志物的蛋白质组学方法
Tommaso Saccon,Matilde Bergamo,Cinzia Franchin
Tommaso Saccon
Inflammatory bowel disease (IBD) is an autoimmune condition with an increasing incidence worldwide, which manifests in two pathological forms: Crohn's disease (CD) or ulcerative colitis (UC). Both cause chronic inflammation of the digestive...
Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment [0.03%]
丙酮酸激酶M2连接代谢和表观遗传学：肝脏疾病治疗的新靶标
Xiaoya Zhang,Danmei Zhang,Jin Guo et al.
Xiaoya Zhang et al.
The aberrant activation of glycolysis plays a pivotal role in the progression of liver diseases. Pyruvate kinase M2 (PKM2), one of the rate-limiting enzymes of glycolysis, not only regulates cellular metabolism but also translocates to the ...
Bile Acids Are Potential Negative Allosteric Modulators of M1 Muscarinic Receptors [0.03%]
胆酸可能是M1毒蕈碱受体的潜在负变构调节剂
Wenbo Yu,Alexander D MacKerell Jr,David J Weber et al.
Wenbo Yu et al.
The proposed physiological roles of bile acids have expanded beyond the digestion of fats to encompass cell signaling via the activation of a variety of nuclear and plasma membrane receptors in multiple organ systems. The current in silico ...
Pinocembrin Downregulates Vascular Smooth Muscle Cells Proliferation and Migration Leading to Attenuate Neointima Formation in Balloon-Injured Rats [0.03%]
Pinocembrin通过下调血管平滑肌细胞增殖和迁移抑制 balloon injury 诱导的新生内膜形成
Hyeonhwa Kim,Jihye Jung,Young-Bob Yu et al.
Hyeonhwa Kim et al.
The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are a primary cause of cardiovascular diseases such as atherosclerosis and restenosis after angioplasty. Pinocembrin (5,7-dihydroxyflavanone, PCB), a natural f...
EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage [0.03%]
基于EET的治疗可减轻索拉非尼相关的肾小球细胞损伤
Abhishek Mishra,Marcus de Bourg,Rawand S Mohamed et al.
Abhishek Mishra et al.
Background: This study investigates how sorafenib induces toxicity in glomerular cells and examines the protective role of 8,9-epoxyeicosatrienoic acid (8,9-EET) analogs in reducing this kidney damage. ...
AARS1 and AARS2: From Protein Synthesis to Lactylation-Driven Oncogenesis [0.03%]
AARS1和AARS2：从蛋白质合成到乳酰化驱动的致癌作用
Lingyue Gao,Jihua Guo,Rong Jia
Lingyue Gao
Aminoacyl-tRNA synthetases (AARSs), traditionally recognized for their essential role in protein synthesis, are now emerging as critical players in cancer pathogenesis through translation-independent functions. Lactate-derived lactylation, ...
LRRK2-Mediated Neuroinflammation-Induced Neuronal Dysfunctions in a Parkinson's and Alzheimer's Disease Cellular Model [0.03%]
LRRK2介导的神经炎症诱导帕金森病和阿尔茨海默病细胞模型中的神经元功能障碍
Veronica Mutti,Giulia Carini,Moira Marizzoni et al.
Veronica Mutti et al.
Chronic neuroinflammation plays a crucial role in the progression of neurodegenerative diseases (NDs), including Parkinson's disease (PD) and Alzheimer's disease (AD). Leucine-Rich Repeat Kinase 2 (LRRK2), a gene linked to familial and spor...
Agnieszka Antonowicz,Patryk Lipiński,Michał Popow et al.
Agnieszka Antonowicz et al.
Hypophosphatemia is a rare ion disorder in children, but it carries the risk of serious clinical sequelae in tissues and organs with high energy requirements, such as bone tissue. This article discusses the metabolism of phosphate in the bo...
Copper Chelation by Penicillamine Protects Against Doxorubicin-Induced Cardiomyopathy by Suppressing FDX1-Mediated Cuproptosis [0.03%]
铜螯合剂青霉胺通过抑制FDX1介导的杯毒症防治阿霉素心肌病
Mohammad El-Nablaway,Hany M A Sonpol,Yaser Hosny Ali Elewa et al.
Mohammad El-Nablaway et al.
Background: The cardiotoxic effects of doxorubicin (DOX), a powerful chemotherapeutic drug, are widely recognized. Cuproptosis, a unique copper-dependent form of controlled cell death, may be involved in DOX-induced cardi...
Population-Level Dynamics and Community-Mediated Resistance to Antimicrobial Peptides [0.03%]
群体水平的动力学和社区介导的抗抗菌肽抵抗力
Theresia Mekdessi,Aracely Devora,Sattar Taheri-Araghi
Theresia Mekdessi
Antimicrobial peptides (AMPs) are crucial components of innate immunity and promising leads for new anti-infective therapies, prized for their broad-spectrum activity and membrane-disruptive mechanisms. However, traditional models of antimi...