Ferroportin at the Crossroads of Iron Biology: Disease, Regulation and Modulation [0.03%]
铁生物学中的关键分子：疾病、调节和调控——铁转运蛋白位于十字路口
Pramudi Hasanga Rathnayake,Nina E Ryan,Ryan Atkins et al.
Pramudi Hasanga Rathnayake et al.
Iron is an essential element for almost all living beings. Ferroportin is the only known cellular iron exporter and is responsible for maintaining iron homeostasis. The hepcidin-ferroportin axis is central to iron regulation. Dysregulation ...
Plasticity of Non-Apoptotic Residual Tumor Cells After Neoadjuvant Immunochemotherapy: Epigenetic and Microenvironmental Determinants [0.03%]
新辅助免疫化疗后残余肿瘤细胞的非凋亡可塑性：表观遗传和微环境决定因素
Wenjun Meng,Ruiyue Li,Peiliang Xie et al.
Wenjun Meng et al.
Neoadjuvant immunochemotherapy (NICT), mainly anti-PD-1/PD-L1 therapy combined with cytotoxic chemotherapy, significantly improved perioperative outcomes for resectable solid tumors such as lung cancer and breast cancer. But a large number ...
Interaction of Alkannin with CPEB4 Contributes to Its Antitumor Effects in Melanoma [0.03%]
阿尔卡宁与CPEB4相互作用有助于其在黑色素瘤中的抗肿瘤作用
Parwen Parhat,Min Li,Wenying Li et al.
Parwen Parhat et al.
Melanoma is a highly aggressive malignancy characterized by strong invasive and metastatic potential. CPEB4 has been implicated in melanoma progression and may serve as a potential therapeutic target. Alkannin has previously been reported t...
Hesperidin and Hesperetin: Epigenetic-Stemness Crosstalk, Antitumor Mechanisms, Preclinical Data and Translation Barriers [0.03%]
芸香素和芸苔素：表观遗传-干细胞相互作用、抗肿瘤机制、临床前数据及转化障碍
Mengqi Guo,Linxin Shao,Huiqing Yin et al.
Mengqi Guo et al.
Hesperidin is a natural flavonoid derived from citrus plants, which can be hydrolyzed into hesperetin in vivo. Both compounds have anti-inflammatory, antioxidant and antitumor activities. At present, there is a lack of reviews focusing on t...
Lithium as a Potential Neuroprotective Strategy in Glaucoma: Mechanisms and Therapeutic Perspectives [0.03%]
锂作为青光眼神经保护策略的潜在手段：机制和治疗前景
Martucci Alessio,Napoleoni Giulia,Adornetto Annagrazia et al.
Martucci Alessio et al.
Glaucoma is a major global health concern, identified as the foremost cause of irreversible blindness, affecting nearly 95 million individuals. It is characterized by the progressive degeneration of retinal ganglion cells (RGCs), leading to...
Narrative Review of the Pathophysiology of Post-Infectious Bronchiolitis Obliterans [0.03%]
气道感染后闭塞性细支气管炎病理生理学综述
Alessandro Zago,Caterina Cocchi,Massimo Maschio et al.
Alessandro Zago et al.
Post-Infectious Bronchiolitis Obliterans (PIBO) is a rare chronic obstructive lung disease characterized by irreversible airflow limitation due to inflammation, fibrosis, and obliteration of the small airways following severe lower respirat...
GDF15 in Liver Fibrosis: Molecular Mechanisms, Immunoregulatory Functions, and Therapeutic Potential [0.03%]
肝纤维化中的GDF15：分子机制、免疫调节功能和治疗潜力
Xinyun Gan,Longze Zhang,Ting Yu et al.
Xinyun Gan et al.
Liver fibrosis is a chronic pathological process driven by the activation of hepatic stellate cell (HSC) and characterized by the excessive deposition of extracellular matrix (ECM) components in response to persistent liver injury. This con...
Bellidifolin Improves Pulmonary Artery Smooth Muscle Cells Proliferation by Targeting the IGFBP5-Mediated PI3K-AKT-mTOR Pathway and Dilates the Pulmonary Artery [0.03%]
铃芙林通过靶向IGFBP5介导的PI3K-AKT-mTOR途径改善肺动脉平滑肌细胞增殖并扩张肺动脉
Qiuqin Hu,Hongmai Wang,Yujie Qiao et al.
Qiuqin Hu et al.
Pulmonary hypertension (PH) is a progressive disease that severely compromises right ventricular function, characterized by two major pathological features: pulmonary arterial constriction and pulmonary arterial remodeling. Bellidifolin (BE...
Targeting Protein Tyrosine Phosphatase 1B: Recent Advances in Natural, Synthetic, and Multitarget Inhibitors for Diabetes Therapy [0.03%]
蛋白酪氨酸磷酸酶1B的靶向研究：糖尿病治疗中天然、合成和多目标抑制剂的最新进展
Laura Braconi,Lorenzo Mattolini,Maria Novella Romanelli et al.
Laura Braconi et al.
Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), represents a major global health challenge, driven by the increasing prevalence of obesity and sedentary lifestyles. T2DM is characterized by insulin resistance and progressiv...
DADA2 as a Model of Monogenic Immune Vasculopathy: From Immunopathogenesis to Precision Therapeutics [0.03%]
DADA2作为单基因免疫血管病模型：从免疫病理发病机制到精准治疗
Hao Peng,Chunxia Li,Chune Mo et al.
Hao Peng et al.
Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disorder caused by biallelic loss-of-function mutations in the ADA2 gene (formerly CECR1). First described in 2014, DADA2 has emerged as a paradigm for monogenic va...