Exploring the Inhibitory Potential of Six Porphyrin Compounds Against α-Amylase and α-Glucosidase Linked to Diabetes [0.03%]
六种卟啉化合物抑制淀粉酶和葡萄糖苷酶的活性研究
Shuo Zhang,Zi Liu,Qiurui Ma et al.
Shuo Zhang et al.
Diabetes mellitus is a characteristic metabolic disorder with diverse complications. α-Amylase and α-glucosidase, as key digestive enzymes regulating blood glucose, are important targets for diabetes prevention and management through thei...
The First Heterozygous TWNK Nonsense Mutation Associated with Progressive External Ophthalmoplegia: Evidence for a New Piece in the Puzzle of Mitochondrial Diseases [0.03%]
首个与进行性外眼肌麻痹相关的TWNK杂合无义突变：线粒体疾病的新证据
Diego Lopergolo,Gianna Berti,Gian Nicola Gallus et al.
Diego Lopergolo et al.
Background: The TWNK gene encodes a protein that colocalizes with mitochondrial DNA (mtDNA) in mitochondrial nucleoids. It acts as mtDNA helicase during replication, thus playing a pivotal role in the replication and main...
Therapeutic Effect of Selenium Nanoparticles, Sorafenib, and Selenium-Sorafenib Nanocomplex in the Lungs and Kidneys of Mice with TAA-Induced HCC [0.03%]
硒纳米颗粒、索拉非尼和硒-索拉非尼纳米复合物对TAA诱导的肝癌小鼠肺和肾脏的治疗作用
Egor A Turovsky,Sergey V Gudkov,Elena G Varlamova
Egor A Turovsky
Hepatocellular carcinoma is a primary malignant tumor of the liver, which is a serious health problem due to its aggressive nature, late diagnosis, and metastasis to other organs. We present, for the first time, the mRNA expression patterns...
The Years 2015-2025 as a Prospective Decade for the Identification of Specific Methylation Biomarkers of Prostate Cancer [0.03%]
2015至2025年前列腺癌特异性甲基化生物标志物鉴定的展望十年
Zohair Selmani,Paul Peixoto,Alexis Overs et al.
Zohair Selmani et al.
For ten years, DNA methylation appeared as a major step in the understanding and issues of prostate cancers. Indeed, although classical biochemical parameters are still useful for prostate cancer diagnosis, they have poor sensitivity and ar...
The Skin Microenvironment: A Dynamic Regulator of Hair Follicle Development, Cycling and Disease [0.03%]
皮肤微环境：动态调节毛囊发育、周期和疾病的因素
Weiguo Song,Mingli Peng,Qiqi Ma et al.
Weiguo Song et al.
As essential skin appendages, hair follicles exhibit complex developmental and regenerative processes shaped by the skin microenvironment. Imbalances in skin microenvironmental homeostasis are often accompanied by follicle miniaturization a...
Therapeutic Convergence in Neurodegeneration: Natural Products, Drug Repurposing, and Biomolecular Targets [0.03%]
神经退行性疾病治疗的趋同性：天然产物、药物再利用和生物分子靶点
Caterina Vicidomini,Giovanni N Roviello
Caterina Vicidomini
Neurodegenerative diseases pose an escalating global health burden, caused by their intricate pathophysiological mechanisms, and consequently, a persistent lack of curative therapies [...].
Patterny: A Troupe of Decipherment Helpers for Intrinsic Disorder, Low Complexity and Compositional Bias in Proteins [0.03%]
模式集：用于识别蛋白质内在无序、低复杂性和组合偏差的辅助诠释团队
Paul M Harrison
Paul M Harrison
Intrinsically disordered regions (IDRs) are sometimes considered parts of the 'dark proteomes', i.e., protein parts that have been largely under-appreciated, as are the overlapping phenomena of low-complexity or compositionally biased regio...
Inorganic Polyphosphate Modulates Chromosome Transmission Fidelity in the Fission Yeast Schizosaccharomyces pombe [0.03%]
无机多聚磷酸调节裂殖酵母染色体传递的保真度
Sarune Bollé,Elisa Koc,Adolfo Saiardi et al.
Sarune Bollé et al.
Chromosome transmission fidelity is vital for organism fitness. Yet, extrinsic and intrinsic changes can affect this process, leading to aneuploidy, the loss/gain of chromosomes, which is a hallmark of cancer. Here, using a haploid fission ...
MiR-92 Controls Synaptic Development Through Glial Vha55 Regulation [0.03%]
miR-92通过调控胶质细胞Vha55控制突触发育
Simon M Moe,Alicia Taylor,Alan P Robertson et al.
Simon M Moe et al.
MicroRNAs (miRNAs) have emerged as important biomarkers for complex neurological conditions. Modifications in synaptic morphology characterize several of these disease states, indicating a possible role of miRNA in modulating synaptic forma...
Tetrahydrocannabivarin (THCV) Dose Dependently Blocks or Substitutes for Tetrahydrocannabinol (THC) in a Drug Discrimination Task in Rats [0.03%]
四氢大麻酚酸(THCV)剂量依赖性地阻断或替代四氢大麻酚(THC)在药物辨别任务中的作用（英文）
Hakan Kayir,Larissa Kouroukis,Iman Aziz et al.
Hakan Kayir et al.
Delta-9-Tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid and structural analog of THC, exhibits a dual pharmacological profile as a CB1 receptor agonist/antagonist and a partial CB2 agonist. This study evaluated the effects ...