Ivana Jovčevska,Alja Videtič Paska,Katarina Kouter
Ivana Jovčevska
The complement system is a vital component of innate immunity. Besides its roles in pathogen defense, its significance in neurodevelopment, neurodegeneration, and cancer progression is beginning to be recognized. We performed a comprehensiv...
Targeting Lactylation: From Metabolic Reprogramming to Precision Therapeutics in Liver Diseases [0.03%]
靶向乳酰化：从代谢重构到肝脏疾病的精确诊疗
Qinghai Tan,Mei Liu,Xiang Tao
Qinghai Tan
Lactylation, a recently identified post-translational modification (PTM) triggered by excessive lactate accumulation, has emerged as a crucial regulator linking metabolic reprogramming to pathological processes in liver diseases. In hepatic...
Cell Settling, Migration, and Stochastic Cancer Gene Expression Suggest Potassium Membrane Flux May Initiate pH Reversal [0.03%]
细胞沉降、迁移及随机癌症基因表达表明钾膜通量可能启动pH逆转
Marie E Beckner
Marie E Beckner
Attraction of glioblastoma cells to potassium was suspected when glioblastoma cells clustered around dying cells and migrated towards serum (high [K+]) and increased potassium. Potassium channel proteins (KCN family, 90 members) mediating a...
Erman Chen,Jingjing Zhang,Han Chen et al.
Erman Chen et al.
Cellular senescence is a fundamental contributor to numerous dysfunctions and degenerative diseases, including osteoporosis. In genetically modified and preclinical animal models, therapeutic strategies targeting persistent senescent cells ...
Novel Neuroactive Steroid Analogs and Voltage-Dependent Blockers of CaV3.2 Currents, B372 and YX23, Are Effective Anti-Nociceptives with Diminished Sedative Properties in Intact Female Mice [0.03%]
新型神经活性甾体类似物和电压依赖性CaV3.2通道阻断剂B372和YX23在完整雌性小鼠中具有有效的镇痛作用，且致静坐作用较小
Benjamin Volvovitz,Rakib Miah,Kibeom Park et al.
Benjamin Volvovitz et al.
Although opioids are effective in treating pain, they cause serious side effects. The use of regional anesthesia, although effective in the perioperative period, may not be suitable if mobility and lack of numbness is desired. Hence, there ...
The Multifaceted Functions of Lactoferrin in Antimicrobial Defense and Inflammation [0.03%]
乳铁蛋白在抗菌防御和炎症中的多重功能
Jung Won Kim,Ji Seok Lee,Yu Jung Choi et al.
Jung Won Kim et al.
Lactoferrin (Lf) is a multifunctional iron-binding glycoprotein of the transferrin family that plays a central role in host defense, particularly in protection against infection and tissue injury. Abundantly present in colostrum, secretory ...
Hepatic Expression of ACBP Is a Prognostic Marker for Weight Loss After Bariatric Surgery [0.03%]
胃旁路手术后体重减轻的预示标志物：肝内ACBP表达水平的作用
Moritz Meyer,Paul Gruber,Christina Plattner et al.
Moritz Meyer et al.
The incidence and prevalence of obesity and related cardio-metabolic diseases are on the rise, posing a critical health care challenge to systems across the globe. Bariatric surgery is a therapeutic cornerstone for morbidly obese patients, ...
Glycosylated SARS-CoV-2 RBD Antigens Expressed in Glycoengineered Yeast Induce Strong Immune Responses Through High Antigen-Alum Adsorption [0.03%]
甘露糖基化SARS-CoV-2 RBD抗原在甘露糖酵母中表达通过高抗原吸附诱导强烈免疫反应
Ai Li,Tiantian Wang,Bin Zhang et al.
Ai Li et al.
Glycosylation plays a pivotal role in regulating the functions and immunogenicity of antigens. Targeting the receptor-binding domain (RBD) of the spike protein (S protein) of SARS-CoV-2, we examined the impact of different glycoforms on RBD...
Low Levels of Adropin Predicted New Incidents of Atrial Fibrillation in Patients with Heart Failure with Preserved Ejection Fraction [0.03%]
低水平的Adropin预测心力衰竭伴射血分数保留患者的房颤新发事件
Tetiana A Berezina,Oleksandr O Berezin,Evgen V Novikov et al.
Tetiana A Berezina et al.
Background: Atrial fibrillation (AF) is common complication of heart failure with preserved ejection fraction (HFpEF) that sufficiently intervenes in the prognosis. The aim of the study is a) to investigate the possible d...
PRDM2-The Key Research Targets for the Development of Diseases in Various Systems [0.03%]
PRDM2-各系统疾病发生发展的关键研究靶点
Shiqi Deng,Hui Li,Chenyu Zhu et al.
Shiqi Deng et al.
PR/SET domain 2 (PRDM2)/RIZ is a member of the histone/protein methyltransferases (PRDMs) superfamily. Discovered to have the ability to bind retinoblastoma in the mid-1990s, PRDM2 was assumed to play a role in neuronal development. Like ot...