From Natriuretic Peptides to microRNAs: Multi-Analyte Liquid Biopsy Horizons in Heart Failure [0.03%]
从利钠肽到microRNA：心力衰竭的多成分液体活检视野
Evelina Charidemou,Kyriacos Felekkis,Christos Papaneophytou
Evelina Charidemou
Heart failure (HF) is a leading cause of morbidity and mortality worldwide, underscoring the need for improved diagnostic, prognostic, and therapeutic strategies. Circulating microRNAs (c-miRNAs) have emerged as promising non-invasive bioma...
Apelin-13-Mediated Upregulation of METTL3 Ameliorates Alzheimer's Disease via Inhibiting Neuroinflammation Through m6A-Dependent Regulation of lncRNA BDNF-AS [0.03%]
Apelin-13通过m6A依赖性调控BDNF-AS抑制神经炎症从而改善阿尔茨海默病的METTL3上调机制研究
Li Han,Siwen Wei,Rong Wang et al.
Li Han et al.
Apelin-13, a neuropeptide, has been recognized for its neuroprotective properties. Our previous study found apelin-13 improves cognitive function in Alzheimer's disease (AD) rats by inhibiting neuroinflammation through upregulation of BDNF/...
Expression of Reelin, Aβ1-42, Tau and FTH1 in Idiopathic Epiretinal Membranes: Exploring the Link Between Reelin and Neurodegenerative Biomarkers [0.03%]
自身免疫性视网膜前膜中Reelin、Aβ1-42、Tau和FTH1的表达：探索Reelin与神经退行性生物标志物之间的联系
Bijorn Omar Balzamino,Esposito Graziana,Cosimi Pamela et al.
Bijorn Omar Balzamino et al.
Growing evidence suggests that Reelin signals and cleavages are affected in neurodegenerative diseases, prospecting a potential role for Reelin in the pathogenesis of neurodegenerative processes occurring in insulted retinas. We sought to d...
Dynamic Interplay Between miR-124-3p and EGF in the Regulation of Overgrowth via RNA Signaling [0.03%]
miR-124-3p和EGF在RNA信号转导调控过度生长过程中的动态交互作用
Keziban Korkmaz Bayram,Arslan Bayram,Zeynep Yilmaz Sukranli et al.
Keziban Korkmaz Bayram et al.
Background: Epigenetic mechanisms and RNA signalling profoundly impact body growth during the early stages of embryonic development. RNA molecules, like microRNAs, play a vital role in early embryonic development, laying the groundwork for ...
Obesity-Mediated Inflammation and Its Influence on Inflammatory Bowel Disease: Pathophysiology, Clinical Impact, and Therapeutic Implications [0.03%]
肥胖介导的炎症及其对炎症性肠病的影响：病理生理学、临床影响和治疗意义
Diego Casas-Deza,Santiago García-López,Vanesa Bernal-Monterde et al.
Diego Casas-Deza et al.
Obesity and inflammatory bowel disease (IBD) are two chronic conditions whose prevalence continues to rise globally. Emerging evidence suggests a bidirectional interplay between them, mediated by shared pathophysiological pathways. This nar...
Exploring the Role of Ferroptosis in the Pathophysiology and Circadian Regulation of Restless Legs Syndrome [0.03%]
探究铁死亡在不安腿综合征病理生理和昼夜调节中的作用
Maria Paola Mogavero,Giovanna Marchese,Giovanna Maria Ventola et al.
Maria Paola Mogavero et al.
The study objectives were to investigate the role of ferroptosis, the mechanism linking iron accumulation, oxidative stress, and dopaminergic dysfunction, in restless legs syndrome (RLS), and to explore its connection with circadian regulat...
Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM [0.03%]
靶向HMGCS2：酮体合成抑制加速2型糖尿病合并NAFLD的进展，而鼠李糖芸香苷改善2型糖尿病并发NASH
Yongsheng Shu,Wanqing Shen,Wanyu Feng et al.
Yongsheng Shu et al.
Patients with concurrent non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) exhibit increased susceptibility to non-alcoholic steatohepatitis (NASH), advanced hepatic fibrosis, cirrhosis, and hepatocellular carcin...
Engineering Protein-Peptide Interfaces via Combinatorial Mutagenesis and Mass Photometric Screening [0.03%]
基于组合突变和质量光度筛查的蛋白质-肽相互作用工程化设计
Bitasadat Hosseini,Mohammed Ashraf,Philip Kitchen et al.
Bitasadat Hosseini et al.
The SpyTag-SpyCatcher system, developed by the Howarth lab, is based on splitting the CnaB2 domain from Streptococcus pyogenes into two parts: a 13-amino-acid SpyTag and a 116-amino-acid SpyCatcher. Upon incubation, they spontaneously form ...
Reconstructing the Antibiotic Pipeline: Natural Alternatives to Antibacterial Agents [0.03%]
重建抗生素供应链：抗菌药物的天然替代品
Chiemerie T Ekwueme,Ifeoma V Anyiam,David C Ekwueme et al.
Chiemerie T Ekwueme et al.
The discovery of penicillin led to remarkable progress in the treatment of diseases and far-reaching advancements in novel antibiotics' development and use. However, the uncontrolled use and abuse of antibiotics in subsequent years have led...
Discovery of Novel 2-Substituted Aniline Pyrimidine Based Derivatives as Potent Mer/c-Met Dual Inhibitors with Improvement Bioavailability [0.03%]
高口服生物利用度的新型2位取代苯胺嘧啶类化合物作为有效Mer/c-Met双靶点抑制剂的研究与发现
Jixia Yang,Daowei Huang,Ruojin Wang et al.
Jixia Yang et al.
This study reports the rational design and systematic evaluation of a novel series of 2-substituted aniline pyrimidine derivatives as dual Mer/c-Met inhibitors. Among the synthesized compounds, 17c demonstrated potent dual kinase inhibition...