Protein Translocation Control in E. coli via Temperature-Dependent Aggregation: Application to a Conditionally Lethal Enzyme, Levansucrase [0.03%]
温度依赖聚集控制的大肠杆菌蛋白转移及在条件致死酶levansucrase中的应用
Young Kee Chae
Young Kee Chae
Precise control of protein translocation is essential for synthetic biology and protein engineering. Here, we present a temperature-responsive system using elastin-like polypeptides (ELPs) to regulate the translocation of a conditionally le...
Dual Regulation of Mitochondrial Complexes by H2S via S-Sulfhydration Controls Respiration in Type 1 Diabetic Hearts [0.03%]
H2S通过硫巯基化对线粒体复合物的双重调节控制1型糖尿病心脏呼吸功能
Tong Su,Li Han Zhu,Jun Xian Liu et al.
Tong Su et al.
Hydrogen sulfide (H2S) has been established to regulate mitochondrial respiration and ATP production, but whether the regulation is through S-sulfhydration (-SSH) of mitochondrial complexes is not well understood. Recently, H2S is known to ...
Recent Advances in the Role of Fibroblast Growth Factors in Hair Follicle Growth [0.03%]
近年来成纤维细胞生长因子在毛囊生长中的作用研究进展
Junchao Wang,Lusheng Wang,Shuang Gao et al.
Junchao Wang et al.
Hair follicles are essential to hair formation and cyclic regeneration, experiencing growth and degeneration, and quiescence phases involving complex signaling pathways. Among these, fibroblast growth factors (FGFs) play a critical role in ...
Humanized Monoclonal Antibody Against Citrullinated Histone H3 Attenuates Myocardial Injury and Prevents Heart Failure in Rodent Models [0.03%]
抗瓜氨酸组蛋白H3的人源化单克隆抗体可减轻啮齿动物模型的心肌损伤并预防心力衰竭
Matthew Weber,Yuchen Chen,Xinyu Zhou et al.
Matthew Weber et al.
Background: Excessive formation of neutrophil extracellular traps (NETs) leads to NETosis, accompanied by the release of citrullinated histone H3 (CitH3), a key mediator of septic inflammation. However, the role of CitH3 in sterile inflamma...
Extracellular Vesicles Derived from Breast Cancer Cells: Emerging Biomarkers of Tumor Progression and Metastasis [0.03%]
乳腺癌细胞衍生的胞外囊泡：肿瘤进展和转移的新兴生物标志物
Sona Bernatova,Andreas Nicodemou,Michaela Cehakova et al.
Sona Bernatova et al.
Breast cancer (BC) remains one of the most prevalent and life-threatening malignancies worldwide, marked by significant heterogeneity and complex mechanisms of progression. Despite major advances in understanding its molecular and cellular ...
Study of the Lipophilicity of Tetracyclic Anticancer Azaphenothiazines [0.03%]
四环抗癌 azaphenothiazine 的疏水性研究
Małgorzata Jeleń,Beata Morak-Młodawska,Małgorzata Dołowy et al.
Małgorzata Jeleń et al.
Although chlorpromazine is primarily used in psychiatry, it has been shown since its introduction to influence the course of neoplastic diseases. According to the strategy of drug repurposing, chlorpromazine has been successfully tested for...
A TRPM2-Driven Signalling Cycle Orchestrates Abnormal Inter-Organelle Crosstalk in Cardiovascular and Metabolic Diseases [0.03%]
TRPM2介导的信号循环协调心血管和代谢性疾病中的细胞器异常互作
Maali AlAhmad,Esra Elhashmi Shitaw,Asipu Sivaprasadarao
Maali AlAhmad
Cardiovascular and metabolic disorders significantly reduce healthspan and lifespan, with oxidative stress being a major contributing factor. Oxidative stress, marked by elevated reactive oxygen species (ROS), disrupts cellular and systemic...
The Role of BRCT Domain from LmjPES in Leishmania major Pathogenesis [0.03%]
布氏冈比亚原生质体BRCT结构域在利什曼原生质体致病性中的作用研究
Esther Larrea,José Peña-Guerrero,Celia Fernández-Rubio et al.
Esther Larrea et al.
Leishmaniasis is caused by protozoan parasites from the genus Leishmania and remains one of the major threats to global health, impacting millions of people worldwide as well as animals including dogs. Several treatments have been used for ...
Changes in Artemin Correlate with Anxiety- and Depression-like Behaviors in a Lipopolysaccharide-Induced Rat Neuroinflammation Model [0.03%]
脂多糖诱导的大鼠神经炎症模型中，Artemin与焦虑和抑郁样行为的相关性研究
Hasan Çalışkan,Seda Koçak
Hasan Çalışkan
Artemin is a neurotrophic factor that belongs to the four-member family of Glial-derived growth factors. This study aims to investigate changes in artemin correlated with anxiety and depression-like behaviors in a neuroinflammation rodent m...
Contribution and Regulation of HIF-1α in Testicular Injury Induced by Diabetes Mellitus [0.03%]
HIF-1α在糖尿病睾丸损伤中的作用及调控研究进展
Defan Wang,Zhenghong Zhang,Renfeng Xu et al.
Defan Wang et al.
Diabetes mellitus, as a metabolic disorder, has received growing attention for its detrimental effects on the male reproductive system (particularly the testes) manifesting as increased oxidative stress, reduced blood perfusion, heightened ...