Transmembrane Protein 97 (TMEM97): Molecular Target and Treatment in Age-Related Macular Degeneration (AMD) [0.03%]
跨膜蛋白97(TMEM97)：年龄相关性黄斑变性的分子靶标与治疗
Alyssa Stathopoulos,Joshua J Wang,Stephen F Martin et al.
Alyssa Stathopoulos et al.
Age-related macular degeneration (AMD) is a common eye disease that significantly affects daily activities and impedes the quality of life in aging adults, yet effective treatments to halt or reverse disease progression are currently lackin...
LncRNA TSPEAR-AS2 Maintains the Stemness of Gastric Cancer Stem Cells by Regulating the miR-15a-5p/CCND1 Axis [0.03%]
长链非编码RNA TSPEAR-AS2通过调控miR-15a-5p/CCND1轴维持胃癌干细胞特性
Qiong Li,Yanan Wang,Liyang Chen et al.
Qiong Li et al.
Cancer stem cells (CSCs), a subpopulation of tumor cells endowed with self-renewal capacity, drive cancer initiation and progression. While long non-coding RNAs (lncRNAs) are increasingly recognized as critical regulators of CSC stemness, t...
From Corncob By-Product to Functional Lignins: Comparative Analysis of Alkaline and Organosolv Extraction Followed by Laccase Treatment [0.03%]
从玉米芯副产物到功能性木质素：碱法和有机溶剂抽提结合漆酶处理的比较分析
Elise Martin,Swarnima Agnihotri,Fabrice Audonnet et al.
Elise Martin et al.
Corncobs, produced globally at over 200 million tons annually with 11-18% lignin content, represent an abundant and underexploited lignocellulosic resource for sustainable lignin valorization. In this study, two distinct extraction methodol...
Comparative Study
Biomolecules. 2025 Aug 26;15(9):1226. DOI:10.3390/biom15091226 2025
Active Peptides from Crayfish Shell: Isolation, Purification, Identification and Cytoprotective Function on Cells Damaged by H2O2 [0.03%]
活性肽的提取、分离、鉴定及其对H2O2损伤细胞的细胞保护作用研究
Chan Bai,Wenqing Wang,Guowei Huang et al.
Chan Bai et al.
This study presents a strategy to develop crayfish shell peptides with enhanced antioxidant and angiotensin-I-converting enzyme (ACE) inhibitory properties. Crayfish shell protein hydrolysates (CSPH1-3) with different molecular weights were...
Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells [0.03%]
Icatibant对人皮肤肥大细胞中的MRGPRX2呈平衡配体作用
Zhuoran Li,Jean Schneikert,Gürkan Bal et al.
Zhuoran Li et al.
MRGPRX2 (Mas-related G protein-coupled receptor member X2) is implicated in mast cell (MC)-driven disorders due to its ability to bind diverse ligands, which may be G-protein-biased or balanced, with the latter activating both G-proteins an...
Beneficial Effects of Different Types of Exercise on Diabetic Cardiomyopathy [0.03%]
不同类型运动对糖尿病心肌病的有益作用
Xiaotong Ma,Haoyang Gao,Ze Wang et al.
Xiaotong Ma et al.
Diabetic cardiomyopathy (DCM) is a serious complication of type 2 diabetes mellitus (T2DM), characterized by cardiac dysfunction, inflammation, and fibrosis. In this study, a T2DM mouse model was established by administering a high-fat diet...
Metabolic Interactions of Side-chain Extended and Unsaturated Vitamin D Analogs with Cytochrome P450 Enzymes: Integrating Theoretical and Experimental Approaches [0.03%]
侧链延长和不饱和维生素D类似物与细胞色素P450酶的代谢相互作用：理论和实验方法的整合
Teresa Żołek,Mayur Kadam,Sharmin Nadkarni et al.
Teresa Żołek et al.
The clinical use of 1,25-dihydroxycholecalciferol (1,25D3), the active form of vitamin D3, is limited by its calcemic side effects and rapid metabolic degradation. To overcome these limitations, we designed novel vitamin D analogs with exte...
Unraveling the Mystery of Hemoglobin in Hypoxia-Accelerated Neurodegenerative Diseases [0.03%]
缺氧加速神经退行性疾病中解密血红蛋白的奥秘
Zhengming Tian,Feiyang Jin,Zhuowen Geng et al.
Zhengming Tian et al.
Hypoxic stress is increasingly recognized as a convergent pathological factor in various age-related neurodegenerative diseases (NDDs), encompassing both acute events such as stroke and traumatic brain injury (TBI), and chronic disorders in...
The Dual Role of Macrophage Extracellular Traps in Host Defense and Disease: Mechanisms and Therapeutic Implications [0.03%]
巨噬细胞胞外诱捕网在宿主防御和疾病中的双刃剑作用：机制与治疗意义
Zhiyu Chen,Fei Gao
Zhiyu Chen
Macrophage extracellular traps (METs), which are extracellular immune structures released by macrophages, consist primarily of double-stranded DNA, histones, elastase, matrix metalloproteinase, myeloperoxidase, and other components. Recent ...
Cannabidiol in Skin Health: A Comprehensive Review of Topical Applications in Dermatology and Cosmetic Science [0.03%]
大麻二酚在皮肤健康中的作用：皮肤病学和化妆品科学中的外用应用综合评述
Aura Rusu,Andreea-Maria Farcaș,Octavia-Laura Oancea et al.
Aura Rusu et al.
Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa L., has emerged as a promising multifunctional agent in dermatology and cosmetic science. The review provides an updated synthesis of CBD's topical therapeu...