Altered Expression of m6A-Associated Genes Is Linked with Poor Prognosis in Pediatric Acute Myeloid Leukemia Patients [0.03%]
m６A相关基因的异常表达与儿童急性髓系白血病不良预后有关
Parminder Kaur,Bollipogu Rajitha,Richa Jain et al.
Parminder Kaur et al.
The dysregulation of m6A-related genes recognized as 'writers', 'readers', and 'erasers' is reported to be involved in the initiation, progression, and drug resistance of acute myeloid leukemia (AML). In the present study, we investigated t...
Depth Correction of TOF-SIMS Depth Profiling Images Using the Total Ion Count Images [0.03%]
基于总离子计数图像的TOF-SIMS深度分布图像深度校正方法
Melanie A Brunet,Brittney L Gorman,Mary L Kraft
Melanie A Brunet
Depth profiling time of flight secondary ion mass spectrometry (TOF-SIMS) enables imaging the distributions of unlabeled metabolites within cells. When depth profiling TOF-SIMS is performed on intact cells, the 3D renderings produced by sta...
Regulatory Ouabain Action on Excitatory Transmission in Rat Hippocampus: Facilitation of Synaptic Responses and Weakening of LTP [0.03%]
调节性鸟苷对大鼠海马兴奋性传递的作用：促进突触反应和削弱长时程增强作用
Yulia D Stepanenko,Dmitry A Sibarov,Sergei M Antonov
Yulia D Stepanenko
Cardiotonic steroids (CTS), including the endogenous compound ouabain, modulate neuronal Na/K-ATPase (NKA) activity in a concentration-dependent manner, affecting neuronal survival and function. While high concentrations of ouabain are neur...
Deciphering the Fasciola hepatica Glycocode and Its Involvement in Host-Parasite Interactions [0.03%]
解码肝片吸虫糖代码及其在宿主寄生相互作用中的作用
Jaclyn Swan,Timothy C Cameron,Terry W Spithill et al.
Jaclyn Swan et al.
The zoonotic disease fasciolosis poses a significant global threat to both humans and livestock. The causative agent of fasciolosis is Fasciola hepatica, which is commonly referred to as liver fluke. The emergence of drug resistance has und...
Serum Growth Differentiation Factor 15 (GDF15) Levels Reflect Ischemic Etiology in Heart Failure Patients with Iron Deficiency: A Cross-Sectional Study [0.03%]
缺铁性心力衰竭患者中血清生长分化因子15(GDF15)水平反映心肌缺血病因的一项横断面研究
Marta Tajes,Maria Del Mar Ras-Jiménez,Josefa Girona et al.
Marta Tajes et al.
Heart failure (HF), particularly of an ischemic etiology, is steadily increasing worldwide. Non-anemic iron deficiency (ID) is highly prevalent among HF patients, and it has been related to worse outcomes. Growth differentiation factor 15 (...
Targeting Focal Adhesion Kinase in Lung Diseases: Current Progress and Future Directions [0.03%]
靶向黏着斑激酶在肺部疾病中的作用：当前进展与未来方向
Ziyu Wan,Zefeng Zhu,Pengbin Wang et al.
Ziyu Wan et al.
Focal adhesion kinase (FAK) is a crucial protein component of focal adhesions (FAs) and belongs to the cytoplasmic non-receptor protein tyrosine kinase family. FAK primarily regulates adhesion signaling and cell migration and is highly expr...
Protective Effect of Low 2-O, 3-O Desulfated Heparin (ODSH) Against LPS-Induced Acute Lung Injury in Mice [0.03%]
低2-O、3-O脱硫酸肝素(ODSH)对脂多糖诱导的小鼠急性肺损伤的保护作用
Joyce Gonzales,Rahul S Patil,Thomas P Kennedy et al.
Joyce Gonzales et al.
Background: Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are critical conditions lacking effective pharmacologic therapies. Lipopolysaccharide (LPS), a bacterial endotoxin, is a...
Comparative Analysis of Aggregation of β- and γ-Synucleins in Vertebrates [0.03%]
脊椎动物β-和γ-突触核蛋白聚集的比较分析
Maria Carmela Bonaccorsi di Patti,Martina Meoni,Mattia Toni
Maria Carmela Bonaccorsi di Patti
This study explores the structural transitions and aggregation behaviour of recombinant β- and γ-synucleins from five vertebrate species-Cyprinus carpio, Danio rerio, Xenopus laevis, Anolis carolinensis, and Homo sapiens-using thioflavin ...
Comparative Study
Biomolecules. 2025 Aug 26;15(9):1231. DOI:10.3390/biom15091231 2025
A De Novo DNM1L Mutation in Twins with Variable Symptoms, Including Paraparesis and Optic Neuropathy [0.03%]
DNM1L新发突变致双生子神经系统异常症候群
Alessia Nasca,Alessia Catania,Andrea Legati et al.
Alessia Nasca et al.
Mitochondrial network dynamics, encompassing processes like fission, fusion, and mitophagy, are crucial for mitochondrial function and overall cellular health. Dysregulation of these processes has been linked to various human diseases. Part...
Case Reports
Biomolecules. 2025 Aug 26;15(9):1230. DOI:10.3390/biom15091230 2025
Obesity Risk Factors Promote Metabolic Reprogramming and Viral Infection in Airways with Type 1 High Inflammation [0.03%]
肥胖风险因素促进第1型高炎症气道中的代谢重构和病毒感染
Paige Hartsoe,Niccolette Schaunaman,Taylor Nichols et al.
Paige Hartsoe et al.
Obesity is a significant health issue, as it is related to human diseases such as asthma and respiratory viral infections. Asthma patients with obesity have more severe diseases, which can be presented with type 1 (e.g., IFN-γ) high inflam...