Repetitive DNAs and Karyotype Evolution in Phyllostomid Bats (Chiroptera: Phyllostomidae) [0.03%]
柄叶蝠科翼手目动物的DNA重复序列与染色体进化关系研究
Geize Aparecida Deon,Tariq Ezaz,José Henrique Forte Stornioli et al.
Geize Aparecida Deon et al.
Bats are great models for studying repetitive DNAs due to their compact genomes and extensive chromosomal rearrangements. Here, we investigated the repetitive DNA content of two phyllostomid bat species, Artibeus lituratus (2nn = 30♀/31♂)...
Consequences of Adhesion Molecule Close Homolog of L1 Deficiency for Neurons and Glial Cells in the Mouse Spinal Cord After Injury [0.03%]
黏附分子L1同源物的缺乏对小鼠脊髓损伤后神经元和胶质细胞的影响后果
Igor Jakovcevski,Ayse Acar,Benjamin Schwindenhammer et al.
Igor Jakovcevski et al.
After spinal cord injury, pathological changes predominantly proceed caudal to the site of injury. To what extent these changes contribute to abnormalities during regeneration is poorly understood. Here, we addressed this question with a lo...
A Novel Clonorchis sinensis Mitogenome: Elucidating Multiregional Strain Phylogeny and Revising the Digenean Mitochondrial Genome Tree [0.03%]
一种新型的肝吸虫线粒体基因组：多地区谱系系统发育及推翻眼鞭毛纲线粒体基因组树修订
Yuxuan Liu,Kaisong Hu,Yanan Zhang et al.
Yuxuan Liu et al.
Clonorchis sinensis, a parasitic liver fluke, is the primary aetiological agent of clonorchiasis, a disease predominantly characterized by liver-related clinical manifestations. Currently, research on the complete mitochondrial (mt) genome ...
Targeting Integrin α2 to Overcome Imatinib Resistance in Chronic Myeloid Leukemia Cells [0.03%]
靶向整合素α2以克服慢性粒细胞白血病细胞的伊马替尼耐药性
Yalda Hekmatshoar,Tulin Ozkan,Arzu Zeynep Karabay et al.
Yalda Hekmatshoar et al.
Chronic myeloid leukemia (CML) is a blood disorder caused by a genetic alteration that creates the BCR-ABL fusion gene, leading to continuous activation of cell growth signals and uncontrolled proliferation of the blood cells. Imatinib (IMA...
Florentina Pluteanu,Boris Musset,Andreas Rinne
Florentina Pluteanu
The cytosolic pH (pHi) of mammalian cells is tightly maintained at values ~7.2. Cytoplasmic acidosis (pHi < 6.8) occurs when the intracellular proton concentration ([H+]i) exceeds the buffering capacity of the cytosol and transport processe...
CD45 and Basigin (CD147) Are Functional Ligands for Galectin-8 on Human Leukocytes [0.03%]
人白细胞上CD45和基底素(CD147)是半乳糖凝集素-8的功能性配体
Jean-Philippe F Gourdine,Porfirio Nava,Alexander J Noll et al.
Jean-Philippe F Gourdine et al.
The interactions of leukocyte glycoproteins with adhesion and signaling molecules through glycan recognition are not well understood. We previously demonstrated that galectin-8, a tandem-repeat lectin with N- and C-terminal carbohydrate bin...
Inhibition of Astrocyte Reactivity by Mdivi-1 After Status Epilepticus in Rats Exacerbates Microglia-Mediated Neuroinflammation and Impairs Limbic-Cortical Glucose Metabolism [0.03%]
Mdivi-1抑制癫痫持续状态后星形胶质细胞活化加剧小胶质细胞介导的神经炎症并损害海马-皮层糖代谢
Francisca Gómez-Oliver,Rubén Fernández de la Rosa,Mirjam Brackhan et al.
Francisca Gómez-Oliver et al.
The lithium-pilocarpine rat model of status epilepticus (SE) is a well-established paradigm for studying epileptogenesis. Astrocyte reactivity has been implicated in modulating seizure susceptibility and neuroinflammation, yet its functiona...
Transcriptome Analysis Unravels CD4+ T-Cell and Treg-Cell Differentiation in Ovarian Cancer [0.03%]
转录组分析揭示卵巢癌中CD4+T细胞和Treg细胞的分化过程
Baoyi Shao,Bo Sun,Zhongdang Xiao
Baoyi Shao
Background: Ovarian cancer ranks as the fifth leading cause of cancer-related mortality among women worldwide. Owing to its insidious onset and lack of early symptoms, over 70% of patients are diagnosed at advanced stages...
The Impact of PCSK9 on Diabetic Cardiomyopathy: Mechanisms and Implications [0.03%]
PCSK9在糖尿病心肌病中的作用机制及意义
Haixia Wang,Pei Wang,Yubo Wang et al.
Haixia Wang et al.
Diabetic cardiomyopathy (DCM) is a common and clinically relevant complication of diabetes mellitus, defined by myocardial dysfunction in the absence of overt coronary artery disease or systemic hypertension. Recent studies have identified ...
Behavioral and Brain Gene and Protein Changes in Female Mice Consuming Ethanol During Pregnancy and Lactation [0.03%]
孕期和哺乳期摄入乙醇的雌性小鼠的行为及大脑基因和蛋白质变化分析
Daniela Navarro,Francisco Navarrete,Nerina Villalba et al.
Daniela Navarro et al.
Alcohol consumption during pregnancy and lactation remains a significant global issue. Preventive policies have proven insufficient, and consumption rates remain high, mainly due to a lack of awareness, the misconception that only high alco...