Nadezhda Bakalenko,Evdokiya Kuznetsova,Konstantin Dergilev et al.
Nadezhda Bakalenko et al.
Mesothelial cells line serosal cavities and internal organs, playing a vital role in maintaining serosal integrity and homeostasis. Their remarkable plasticity and ability to undergo mesothelial-to-mesenchymal transition (MMT) position them...
Phosphomimetic Thrombospondin-1 Modulates Integrin β1-FAK Signaling and Vascular Cell Functions [0.03%]
丝氨酸磷酸化模拟的 thrombospondin-1 对整合素β1-FAK 信号通路及血管细胞功能的调节作用
Assala Raya,Bálint Bécsi,Anita Boratkó
Assala Raya
Thrombospondin-1 (TSP1) is a multifunctional glycoprotein that plays a crucial role in angiogenesis and vascular remodeling. Ser93 of TSP1 has recently been identified as a novel phosphorylation site, influencing angiogenic properties; howe...
Emerging Roles of Tubulin Isoforms and Their Post-Translational Modifications in Microtubule-Based Transport and Cellular Functions [0.03%]
微管依赖的运输和细胞功能中的新生tublin异构体及其修饰的作用
Aishwarya R Nair,Nived Saroj,Ambarish Kunwar
Aishwarya R Nair
Microtubules are hollow cylindrical polymers made up of tubulin. This heterodimeric protein, tubulin, exists in multiple forms: tubulin isotypes and tubulin isoforms. Distinct α- and β-tubulin genes give rise to tubulin isotypes, which di...
Telomere-to-Telomere Genome Assembly of Two Hemiculter Species Provide Insights into the Genomic and Morphometric Bases of Adaptation to Flow Velocity [0.03%]
端粒到端粒基因组组装揭示两种中华钩口虾科鱼类适应流速的基因组和形态基础
Jie Liu,Denghua Yin,Fengjiao Ma et al.
Jie Liu et al.
Flow velocity is a key environmental factor that exerts multifaceted effects on fish growth and adaptation. Through long-term natural selection, fish have evolved adaptability to specific flow conditions, which not only relate to oxygen sup...
Isolation and Characterization of a Biocontrol Serine Protease from Pseudomonas aeruginosa FZM498 Involved in Antagonistic Activity Against Blastocystis sp. Parasite [0.03%]
一株铜绿假单胞菌(FZM498)拮抗溶组织内阿米巴原虫的生物防治蛋白酶的分离和鉴定
Fatimah Z Almilad,Essam Kotb,Hanadi B Baghdadi et al.
Fatimah Z Almilad et al.
The intestine is considered a habitat for both bacteria and parasites. In this study, many fecal bacterial isolates and the protozoan Blastocystis sp. were recovered from stool samples of individuals with gastrointestinal conditions. Isolat...
Effect of Sulfated Polysaccharides and Laponite in Composite Porous Scaffolds on Osteogenesis [0.03%]
复合多孔支架中硫酸化多糖和拉泊タイト对成骨的影响
Angelina Karamesouti,Maria Chatzinikolaidou
Angelina Karamesouti
The design of biomaterial scaffolds for bone tissue engineering requires a balance between bioactivity, porosity, mechanical stability, and osteoinductivity. Kappa- (KC) and iota-carrageenan (IC) have been explored for scaffold fabrication ...
Trends in Inhibitors, Structural Modifications, and Structure-Function Relationships of Phosphodiesterase 4: A Review [0.03%]
磷二酯酶4抑制剂、结构修饰及构效关系研究进展综述
Antonio Sánchez-Belmonte,Adrián Matencio,Irene Conesa et al.
Antonio Sánchez-Belmonte et al.
Phosphodiesterase 4 (PDE4) is a key enzyme responsible for the hydrolysis of cyclic adenosine monophosphate (cAMP), thereby regulating essential signaling pathways involved in inflammation and immune modulation. Structural studies have demo...
Mechanism of T7 Primase Selecting Active Priming Sites Among Genome [0.03%]
T7 原核酶选择作用基因组中有效引发位点的机制研究
Zhiming Zhang,Jiang Chen,Wenyue Liu et al.
Zhiming Zhang et al.
In bacteriophage T7, the primase synthesizes primer at a specific site, 5'-(G/T)2GTC-3'. However, the pentanucleotide alone cannot define the activity of the primase. In this study, we demonstrated that the 10-nt sequence flanking the 3' en...
Crystalline Insights into Nasal Mucosa Inflammation and Remodeling: Unveiling Role of Galectin-10 [0.03%]
鼻黏膜炎症和重塑的结晶洞察：揭示半乳糖凝集素-10的作用
Olga Maria Manna,Velia Malizia,Andrea Perri et al.
Olga Maria Manna et al.
Background: Galectin-10 (Gal-10), the main constituent of Charcot-Leyden crystals, is a recognized marker of eosinophilic inflammation, yet its role in nasal mucosal remodeling in Seasonal Allergic Rhinitis (SAR) remains ...
Ionotropic Receptors as Potential Targets Against Insect-Transmitted Diseases [0.03%]
离子型受体作为针对昆虫传播疾病潜在靶标的潜力
João Pessoa
João Pessoa
Insects can remotely detect human temperature, odor, and other stimuli as part of their host-seeking strategy. Such detection involves specific biomolecules, whose inhibition could limit host spotting and decrease the spread of insect-trans...