Unravelling the Connection Between Energy Metabolism and Immune Senescence/Exhaustion in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome [0.03%]
慢性疲劳综合症患者能量代谢和免疫衰老/耗竭之间联系的解析
Jente Van Campenhout,Yanthe Buntinx,Huan-Yu Xiong et al.
Jente Van Campenhout et al.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease, characterized by a diverse array of symptoms including post-exertional malaise (PEM), severe fatigue, and cognitive impairments, all of which drastically...
PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer [0.03%]
由ASIC1介导的PFKM依赖性糖酵解途径促进肝癌细胞在酸性微环境中的存活率
Xiaomin Wu,Boshi Wang,Yingjian Hou et al.
Xiaomin Wu et al.
The acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver canc...
Scrutinizing Stator Rotation in the Bacterial Flagellum: Reconciling Experiments and Switching Models [0.03%]
重新审查细菌鞭毛中的定子旋转：实验与切换模型的一致性
Ayush Joshi,Pushkar P Lele
Ayush Joshi
The bacterial flagellar motor is one of the few known rotary motors, powering motility and chemotaxis. The mechanisms underlying its rotation and the switching of its rotational direction are fundamental problems in biology that are of sign...
Malgorzata Kloc,Jarek Wosik
Malgorzata Kloc
Individual cells and cells within the tissues and organs constantly face mechanical challenges, such as tension, compression, strain, shear stress, and the rigidity of cellular and extracellular surroundings. Besides the external mechanical...
Application of Thyroid Hormones in Women's Hair for the Non-Invasive Prediction of Graves' Disease [0.03%]
甲状腺激素在女性头发中的应用以非侵袭性预测Graves病
Kouhei Igarashi,Chie Takita,Masako Matsumoto et al.
Kouhei Igarashi et al.
Graves' disease (GD) is an autoimmune disorder that can be difficult to distinguish from other diseases due to symptom similarity. The exacerbation of GD owing to delayed diagnosis is a serious issue, and a novel accessible health screening...
Synthesis, Antiproliferative Activity, and ADME Profiling of Novel Racemic and Optically Pure Aryl-Substituted Purines and Purine Bioisosteres [0.03%]
新型外消旋和光学纯的芳基取代嘌呤及嘌呤生物等排体的合成，抗增殖活性以及ADME特征分析
Martina Piškor,Astrid Milić,Sanja Koštrun et al.
Martina Piškor et al.
The aim of this study was to synthesize new racemic and optically pure aryl-substituted purine bioisosteres using ultrasound-assisted Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. Regioselective synthesis of α-azido alcohols was appli...
Cetuximab and Paclitaxel Drug Response in Head and Neck Tumor Stem Cells [0.03%]
头颈肿瘤干细胞中的西妥昔单抗和紫杉醇药物反应研究
Vilson Serafim Júnior,Glaucia Maria de Mendonça Fernandes,Bianca Barbério Bogdan Tedeschi et al.
Vilson Serafim Júnior et al.
Head and neck cancer (HNC) is one of the most common types of cancer in the world, characterized by resistance to conventional therapies and an unfavorable prognosis due to the presence of tumor stem cells (TSCs). TSCs are cell subpopulatio...
Ru(II) Complexes with 3,4-Dimethylphenylhydrazine: Exploring In Vitro Anticancer Activity and Protein Affinities [0.03%]
带有3,4-二甲基苯肼的Ru(II)复合物：探索体外抗癌活性和蛋白质亲和性
Jasmina Dimitrić Marković,Dušan Dimić,Thomas Eichhorn et al.
Jasmina Dimitrić Marković et al.
Two new Ru(II) complexes, mononuclear [RuCl2(η6-p-cymene)(3,4-dmph-κN)] (1) and the binuclear complex [{RuCl(η6-p-cymene)}2(μ-Cl)(μ-3,4-dmph-κ2N,N')]Cl (2; 3,4-dmph = 3,4-dimethylphenylhydrazine), are synthesized and experimentally an...
Renal Implications of Dysregulated Protein Homeostasis: Insights into Ubiquitin-Proteasome and Autophagy Systems [0.03%]
蛋白质稳态失调对肾的影响：关于泛素-蛋白酶体和自噬系统的新见解
Charlotte Delrue,Marijn M Speeckaert
Charlotte Delrue
The ubiquitin-proteasome system (UPS) and autophagy maintain protein homeostasis, which is critical to cellular function and survival. The dysregulation of these pathways has been recognized as a hallmark of acute kidney injury and chronic ...
Daniel E Johnson,Zhibin Cui
Daniel E Johnson
Pyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of cell death, canonical pyroptosis involves the specific cleavage of gasdermin...