A Review of Fluoroquinolones with a Focus on Veterinary-Approved Agents [0.03%]
氟喹诺酮类抗生素研究:focus于兽用氟喹诺酮类抗生素
Joseph M Blondeau
Joseph M Blondeau
Fluoroquinolones are broad-spectrum, bactericidal antibacterial agents used in both human and veterinary medicine. Some human-approved drugs are used off label in veterinary medicine while veterinary-approved drugs are not used in humans. V...
Naturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit-Risk Considerations in Policy and Clinical Development [0.03%]
用于治疗目的的天然来源赛洛西宾：政策和临床开发中证据、安全性和利弊考量的六项标准框架
Stefanie Enriquez-Geppert,Lisa Bevers,Arvid Rosander et al.
Stefanie Enriquez-Geppert et al.
Naturally derived psilocybin is widely used, yet its therapeutic potential, pharmacological distinctiveness and regulatory feasibility remain understudied. This review evaluates the potential of naturally derived psilocybin using a six-crit...
CFTR and ClC-3 Transport Fluoride Differently and Cause Dental Fluorosis in Different Ways [0.03%]
CFTR和ClC-3转运氟离子的方式不同且导致龋齿氟斑病的机制也不同
Yanli Zhang,Songya Mao,Xuan Wen et al.
Yanli Zhang et al.
Dental fluorosis (DF) is a common endemic disease that damages dental enamel. Traditionally, DF has been attributed to environmental fluoride overload. Accumulating evidence has demonstrated that genetic factors also modulate individual sus...
Network Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class) [0.03%]
网络拓扑和互作组分析揭示人类肽家族(Humanin蛋白家族(MTRNR2Lx类))的调控框架
Mohd Shahzaib,Domenico Aprile,Gianluigi Laporta et al.
Mohd Shahzaib et al.
This study presents an in-depth analysis of an interactome comprising approximately 1033 nodes, focusing on its topology, reliability, and functional implications, with particular attention to the small mitochondrial proteins of the Humanin...
HDAC3 as an Immunometabolic Rheostat: Molecular Mechanisms of Deacylation Plasticity, Lactylation Dynamics, and Spatiotemporal Regulation [0.03%]
组蛋白去乙酰化酶3：脱酰化可塑性、乳酰化动态及时空调节的免疫代谢调节点机制分子机制
Yifan Bu,Wanying Li,Songzhe Li et al.
Yifan Bu et al.
Histone deacetylase 3 (HDAC3) is a key node linking immunometabolism, chromatin regulation, and inflammatory transcriptional programs. Rather than functioning simply as a nuclear deacetylase, HDAC3 output is jointly shaped by corepressor-co...
Microbial Lignin Valorization to Protocatechuic Acid and Catechol: Biofunneling Pathways and Metabolic Engineering Strategies [0.03%]
微生物将木质素转化为原邻苯二酚和儿茶酚：生物漏斗路径及代谢工程策略
Yoganathan Kamaraj,Shehbaz Ali,Sethupathy Sivasamy et al.
Yoganathan Kamaraj et al.
Lignin, an abundant and renewable aromatic biopolymer, represents a largely underutilized resource for the sustainable production of high-value chemicals. Among lignin-derived intermediates, protocatechuic acid (PCA) and catechol have emerg...
Design, Synthesis, and Antitumor Activities of Novel Coumarin-Based Histone Deacetylase Inhibitors [0.03%]
新型香豆素类组蛋白去乙酰化酶抑制剂的设计、合成及抗肿瘤活性
Sichang Yan,Jie Chang,Dongyu Lei et al.
Sichang Yan et al.
Histone deacetylases (HDACs) are important epigenetic regulatory enzymes contributing to cancer proliferation, which could be critical targets in cancer therapy. The structural similarities of the existing HDAC inhibitors have resulted in a...
Prodigiosin Enhanced TMZ Chemosensitivity by Suppressing Focal Adhesion and Inhibiting Autophagy in Glioblastoma Cells [0.03%]
三价金属嗪化疗敏感性增强通过抑制焦点粘附和抑制自噬在胶质母细胞瘤细胞中抑制斑疹毒素
Shihui Dai,Xin Liu,Xiangyu Jin et al.
Shihui Dai et al.
Glioblastoma (GBM) remains a lethal brain tumor with poor prognosis and limited therapeutic efficacy from temozolomide (TMZ) treatment. Prodigiosin (PG), a bioactive secondary metabolite, has demonstrated anti-tumor activity across a broad ...
Hypoxic Preconditioning: An Underestimated Endogenous Protective Strategy? [0.03%]
低氧预处理：一种被低估的内源性保护策略？
Jinqiao Liu,Changhong Ren,Tariq Kermalli et al.
Jinqiao Liu et al.
Hypoxic Preconditioning (HPC) describes the phenomenon whereby brief, non-lethal hypoxic episodes enhance cellular resilience to subsequent severe hypoxia. Initially recognized in altitude studies, HPC has since been linked to broad protect...
Biological Activity and Structure-Activity Relationship of Mono- and Bis-Derivatives of 3-(Arylamino)propanehydrazides [0.03%]
单体和双体-3-(芳氨基)丙烷胲的生物活性及构效关系研究
Ingrida Tumosienė,Ilona Jonuškienė,Neringa Petrašauskienė et al.
Ingrida Tumosienė et al.
A series of N'-(4-nitrobenzylidene)propanehydrazides and corresponding bishydrazones, as well as N-(1,3-dioxoisoindolin-2-yl)propanamides and corresponding bis(propanamides), were synthesised. Antioxidant properties were assessed using redu...