Models for antitubercular activity of 5â-O-[(N-Acyl)sulfamoyl]adenosines [0.03%]
5'-O-[(N-乙酰基)磺胺基]腺苷类抗结核活性的模型研究
Rakesh K Goyal,Harish Dureja,Gajendra Singh et al.
Rakesh K Goyal et al.
The relationship between topological indices and antitubercular activity of 5â-O-[(N-Acyl)sulfamoyl]adenosines has been investigated. A data set consisting of 31 analogues of 5â-O-[(N-Acyl)sulfamoyl]adenosines was selected for the present...
Synthesis, photochemical and photoinduced antibacterial activity studies of meso-Tetra(pyren-1-yl)porphyrin and its Ni, Cu and Zn complexes [0.03%]
次甲基四（吡啶-1-基）卟啉及其镍、铜和锌配合物的合成、光化学及光致抗菌活性研究
Tamara Zoltan,Franklin Vargas,Carlos Rivas et al.
Tamara Zoltan et al.
The synthesis of the meso-tetra(pyren-1-yl)porphyrin (1) was successfully accomplished by means of the pyrrole condensation with pyrene-1-carb-aldehyde in acidic media. Its metallization was carried out in an almost quantitative yield to ob...
New 4-thiazolidinones of nicotinic acid with 2-Amino-6-methylbenzothiazole and their biological activity [0.03%]
新型烟酸类4-噻唑烷酮及2-氨基-6-甲基苯并噻唑衍生物的合成及其活性研究
Navin B Patel,Faiyazalam M Shaikh
Navin B Patel
The title compounds 6aâj, 2-[(6-methyl-1,3-benzothiazol-2-yl)amino]-N-[2-(substituted phenyl/furan-2-yl)-4-oxo-1,3-thiazolidin-3-yl]nicotinamides, were prepared from 2-chloropyridine-3-carboxylic acid (1) and 2-amino-6-methyl-benzothiazole...
Synthesis and antimicrobial activity of long-chain 3,4-Epoxy-2-alkanones [0.03%]
长链3,4-环氧-2烷酮的合成及抗菌活性研究
William F Wood
William F Wood
3,4-Epoxy-2-dodecanone, a major component in the preorbital gland of the African grey duiker (Sylvicapra grimmia), showed antimicrobial activity in preliminary tests. The C(11) to C(17) homologues of this compound were prepared and their ac...
Effects of Garlic on Cytochromes P450 2C9- and 3A4-Mediated Drug Metabolism in Human Hepatocytes [0.03%]
大蒜对人类肝细胞中细胞色素P450 2C9和3A4介导的药物代谢的影响
Beatrice E Ho,Danny D Shen,Jeannine S McCune et al.
Beatrice E Ho et al.
Several reports suggest garlic supplements may inhibit the metabolism of cytochrome P450 (CYP) 2C9 and CYP3A4 substrates, such as warfarin and saquinavir. To characterize the effects of garlic extract on CYP2C9 and CYP3A4 enzyme activity im...