Simultaneous determination of different polyamines and their mono-acetylated derivatives in gastric tissue by HPLC with post-column derivatization [0.03%]
毛细管电泳-安培检测法用于同时测定人精液中的多巴胺、去甲肾上腺素和苯乙醇胺
Muhammad Raza,Othman A Al-Shabanah
Muhammad Raza
A simple and highly sensitive procedure is described enabling the simultaneous determination of biogenic polyamines (PAs) and their related monoacetyl derivatives in stomach tissue. The method is based on HPLC using octane sulfonate as an i...
3D-QSAR design of new escitalopram derivatives for the treatment of major depressive disorders [0.03%]
用于治疗重度抑郁症的新艾司西酞普兰衍生物的三维定量结构活性关系（QSAR）设计研究
Speranta Avram,Catalin Buiu,Daniel M Duda-Seiman et al.
Speranta Avram et al.
Antidepressants are psychiatric agents used for the treatment of different types of depression being at present amongst the most commonly prescribed drug, while their effectiveness and adverse effects are the subject of many studies and com...
Evaluation of the pharmaceutical quality of docetaxel injection using new stability indicating chromatographic methods for assay and impurities [0.03%]
采用新的稳定性指示色谱法测定多西他赛注射液的药学质量评估方法及杂质鉴定方法评估
Annarapu Malleswara Reddy,Nagaraju Banda,Shinde Govind Dagdu et al.
Annarapu Malleswara Reddy et al.
New stability indicating chromatographic methods have been developed for estimation of Assay and Impurities of Docetaxel in Docetaxel injection for evaluation of pharmaceutical quality. With this method, the process related impurities and d...
Pharmacophore elucidation and molecular docking studies on 5-phenyl-1-(3-pyridyl)-1h-1,2,4-triazole-3-carboxylic acid derivatives as COX-2 inhibitors [0.03%]
5-苯基-1-(3-吡啶基)-1H-1,2,4-三氮唑-3-甲酸衍生物作为COX-2抑制剂的药效团分析及分子对接研究
Marc Lindner,Wolfgang Sippl,Awwad A Radwan
Marc Lindner
A set of 5-phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic acid derivatives (16â32) showing anti-inflammatory activity was analyzed using a three-dimensional qualitative structure-selectivity relationship (3D QSSR) method. The Catalyst...
Synthesis and antimicrobial activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones [0.03%]
3-(1,3,4-噁二唑-2-基)喹唑啉-4(3H)-酮的合成及其抗菌活性研究
Navin B Patel,Jaymin C Patel
Navin B Patel
In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activity of various 3-(1,3,4-oxadiazol-2-yl)-quinazolin-4(3H)-ones. The antimicrobial activity of title compounds were examin...
Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones [0.03%]
新型2位取代的1,4-苯并二氮卓-2-酮的抗抑郁/抗焦虑及镇痛作用
Harjit Singh,Jintana Sattayasai,Pornthip Lattmann et al.
Harjit Singh et al.
Oxazepam (4a) has been used as overall starting material in the synthesis of novel 2-substituted 1,4-benzodiazepines.By reacting Oxazepam 4a with commercially available hydrazines, hydrazides, semicarbazide, aminoguanidine and N,N-dimethyla...
Syed Haris Omar
Syed Haris Omar
Olive from Olea europaea is native to the Mediterranean region and, both the oil and the fruit are some of the main components of the Mediterranean diet. The main active constituents of olive oil include oleic acid, phenolic constituents, a...
Acute administration of clozapine and risperidone altered dopamine metabolism more in rat caudate than in nucleus accumbens: a dose-response relationship [0.03%]
氯氮平和利培酮急性给药剂量反应关系对大鼠尾核多巴胺代谢的影响大于伏隔核
Farhat Batool,Muhammad A Haleem,Darakhshan J Haleem
Farhat Batool
The present study compares the extrapyramidal and neurochemical effects of clozapine and risperidone in rat caudate (corpus striatum) and nucleus accumbens (ventral striatum) dose-dependently. Animals injected with clozapine (2.5, 5.0 and 1...
Vipin Sharma,Rakesh Kumar Marwaha,Harish Dureja
Vipin Sharma
In the present study, chitosan membranes capable of imitating permeation characteristics of diclofenac diethylamine across animal skin were prepared using cast drying method. The effect of concentration of chitosan, concentration of cross-l...
Carbopol/chitosan based pH triggered in situ gelling system for ocular delivery of timolol maleate [0.03%]
卡波姆/壳聚糖基pH触发的体内凝胶系统用于美开朗的眼用递送
Swati Gupta,Suresh P Vyas
Swati Gupta
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic preparations due to rapid precorneal elimination, dilution and nasolacrimal drainage of the drug may be vanquished by the use of in situ gelling systems ...