Quantification of 6-Mercaptopurine and Its Metabolites in Patients with Acute Lympoblastic Leukemia Using Dried Blood Spots and UPLC-MS/MS [0.03%]
采用干血滴纸片和UPLC-MS/MS法测定急性淋巴细胞白血病患者6-MP及其代谢产物的浓度分布
Supandi Supandi,Yahdiana Harahap,Harmita Harmita et al.
Supandi Supandi et al.
This research aimed to quantitatively bioanalyze 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5′-monophosphate (6-TGMP) in dried blood spots (DBS) prepared from a small volume of acute lymphoblastic leu...
Betulin-3,28-diphosphate as a Component of Combination Cytostatic Drugs for the Treatment of Ehrlich Ascites Carcinoma In Vitro and In Vivo Experiments [0.03%]
白桦脂醇-3,28-二磷酸作为抗肿瘤药物组合用于体外和体内艾氏腹水瘤治疗的成分
Olga Vorobyova,Olga Deryabina,Darina Malygina et al.
Olga Vorobyova et al.
The activity of betulin-3,28-diphosphate (BDP) in combination with the cytostatics such as 5-fluorouracil (5-FU) and hydrazine sulfate (HS) was demonstrated by using the transplanted Ehrlich ascites carcinoma (EAC) in mice. The dose-depende...
Ocular Delivery System for Propranolol Hydrochloride Based on Nanostructured Lipid Carrier [0.03%]
基于纳米结构脂质载体的普萘洛尔盐酸盐眼用递送系统
Behzad Sharif Makhmal Zadeh,Hassan Niro,Fakher Rahim et al.
Behzad Sharif Makhmal Zadeh et al.
One drawback of traditional forms of medical ocular dosage is drug dilution by tear; moreover, drugs are rapidly drained away from pre-corneal cavity by tear flow and lacrimo-nasal drainage. Prolonging contact time with different strategies...
Novel Mutations in pncA Gene of Pyrazinamide Resistant Clinical Isolates of Mycobacterium tuberculosis [0.03%]
吡嗪酰胺耐药临床分离结核分枝杆菌pncA基因新突变分析
Manijeh Kahbazi,Hossein Sarmadian,Azam Ahmadi et al.
Manijeh Kahbazi et al.
In clinical isolates of Mycobacterium tuberculosis (MTB), resistance to pyrazinamide occurs by mutations in any positions of the pncA gene (NC_000962.3) especially in nucleotides 359 and 374. In this study we examined the pncA gene sequence...
Honey Bee as Alternative Medicine to Treat Eleven Multidrug-Resistant Bacteria Causing Urinary Tract Infection during Pregnancy [0.03%]
蜜蜂作为治疗孕妇泌尿系统感染的 multidrug-resistant细菌的替代药物疗法
Mabrouka Bouacha,Hayette Ayed,Nedjoud Grara
Mabrouka Bouacha
Medicinal benefits of honey bee have been recognized in the medical community since ancient times as a remedy for many diseases and infections. This study aimed to investigate the in vitro susceptibility of 11 multidrug-resistant bacterial ...
Gliadin Peptide Facilitates FITC Dextran Transport across the Non Everted Gut Sac of Rat Small Intestine [0.03%]
葡萄球菌肠毒素基因型与宿主反应关系的研究进展
Ratna Annisa Utami,Aunillah Hakiki,Sukmadjaja Asyarie et al.
Ratna Annisa Utami et al.
Superoxide dismutase (SOD) is an antioxidant protein. When administered orally, it has low bioavailability due to its low permeation. In a previous study we fused gliadin peptide P51 (LGQQQPFPPQQPYPQPQPF) and gliadin peptide P61 (QQPYPQPQPF...
N-Aryl-7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido-[3,2,1-ij]quinoline-6-carboxamides. The Synthesis and Effects on Urinary Output [0.03%]
N-Aryl-7-羟基-5-氧代-2,3-二氢-1H,5H-吡啶并[3,2,1-ij]喹啉-6-甲酰胺类化合物的合成及其利尿作用研究
Igor V Ukrainets,Lyudmila V Sidorenko,Mykola Y Golik et al.
Igor V Ukrainets et al.
Continuing a targeted search for new leading structures with diuretic action among tricyclic derivatives of hydroxyquinolines, which are of interest as potential inhibitors of aldosterone synthase, the synthesis of a series of the correspon...
Acetylcholinesterase Inhibition and Antioxidant Activity of N- trans-Caffeoyldopamine and N- trans-Feruloyldopamine [0.03%]
反式咖啡酸多巴胺和反式阿魏酸多巴胺的乙酰胆碱酯酶抑制作用和抗氧化活性
Muamer Dizdar,Danijela Vidic,Franc Požgan et al.
Muamer Dizdar et al.
Phenolic acids and their derivatives found in nature are well-known for their potential biological activity. In this study, two amides derived from trans-caffeic/ferulic acid and dopamine were synthesized and characterized by Fourier-transf...
Application of the P300 Event-Related Potential in the Diagnosis of Epilepsy Disorder: A Review [0.03%]
P300事件相关电位在癫痫诊断中应用的研究进展综述
Kandhasamy Sowndhararajan,Minju Kim,Ponnuvel Deepa et al.
Kandhasamy Sowndhararajan et al.
Epilepsy is one of the most serious chronical neurological disorders, affecting more than 50 million people worldwide. It can be defined as a spectrum disorder, and patients with epilepsy possess abnormalities in cognitive functions. A numb...
4-Methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylic Acid. Peculiarities of Preparation, Structure, and Biological Properties [0.03%]
4-甲基-2,2-二氧代-1H-2λ⁶，1-苯并噻嗪-3-羧酸：制备、结构及生物性质的特殊性
Igor V Ukrainets,Ganna M Hamza,Anna A Burian et al.
Igor V Ukrainets et al.
In order to determine the regularities of the structure-analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylic acid and s...