Chrysin Protects Rat Kidney from Paracetamol-Induced Oxidative Stress, Inflammation, Apoptosis, and Autophagy: A Multi-Biomarker Approach [0.03%]
染料木素通过多生物标志物途径对乙酰氨基酚诱导的大鼠肾脏氧化应激、炎症、凋亡和自噬的保护作用研究
Fatih Mehmet Kandemir,Sefa Kucukler,Eyup Eldutar et al.
Fatih Mehmet Kandemir et al.
Paracetamol (PC) is a safe analgesic and antipyretic drug at therapeutic doses, and it is widely used in clinics. However, at high doses, it can induce hepatotoxicity and nephrotoxicity. Chrysin (CR) is a natural flavonoid that has biologic...
Quality Control of Traditional Cannabis Tinctures: Pattern, Markers, and Stability [0.03%]
传统大麻酊的质量控制：特征、标志物及稳定性研究
Wieland Peschel
Wieland Peschel
Traditional tinctures of Cannabis sativa L. became obsolete before elucidation of the main cannabinoids and routine quality testing for medicines. In view of increasing medicinal use of cannabinoids and associated safety concerns, tinctures...
Metabolite Profiles in Various Plant Organs of Justicia gendarussa Burm.f. and Its in Vitro Cultures [0.03%]
米仔兰不同组织及离体培养物的次生代谢产物分析
Putu Indrayoni,Diah Intan Purwanti,Suwidji Wongso et al.
Putu Indrayoni et al.
Metabolite profiles of plant organs and their in vitro cultures of Justicia gendarussa have been studied by using Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometry (UPLC-Qtof-MS). Samples of leaves, stems, ...
In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb [0.03%]
福马利亚草(Schleicher)fumaria中提取物及原阿片碱的体内抗惊厥作用
Yuliya Prokopenko,Vadim Tsyvunin,Sergey Shtrygol&#x; et al.
Yuliya Prokopenko et al.
The present study aimed to investigate the role of several biologically active compounds from Fumaria schleicheri Soy.-Will. in anticonvulsant models. The flavonoid fraction, alkaloid fraction, individual alkaloid protopine, and polysacchar...
Investigation of the Bioequivalence of Rosuvastatin 20 mg Tablets after a Single Oral Administration in Mediterranean Arabs Using a Validated LC-MS/MS Method [0.03%]
用LC-MS/MS验证的方法单次口服20毫克罗苏伐他汀片在地中海阿拉伯人中的生物等效性研究
Abdel Naser Zaid,Rowa Al Ramahi,Rita Cortesi et al.
Abdel Naser Zaid et al.
There is a wide inter-individual response to statin therapy including rosuvastatin calcium (RC), and it has been hypothesized that genetic differences may contribute to these variations. In fact, several studies have shown that pharmacokine...
Synthesis, Structure, and Analgesic Properties of Halogen-Substituted 4-Hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxanilides [0.03%]
卤素取代的4-羟基-2,2-二氧代-1H-2λ⁶，1-苯并噻嗪-3-羧基苯胺类化合物的合成、结构及镇痛性质研究
Igor V Ukrainets,Lidiya A Petrushova,Svitlana V Shishkina et al.
Igor V Ukrainets et al.
As potential new analgesics, the corresponding 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxanilides have been obtained by amidation of ethyl 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylate with aniline and its halogenate...
Bioequivalence Study of Two Orodispersible Rizatriptan Formulations of 10 mg in Healthy Volunteers [0.03%]
两种利扎曲普坦舌下含片（每片10mg）在健康志愿者中的生物等效性研究
Mercè Cánovas,Francisco Polonio,Francesc Cabré
Mercè Cánovas
The aim of the study was to assess the bioequivalence and tolerability of two different oral formulations of rizatriptan. A bioequivalence study was carried out in 40 healthy volunteers according to an open label, randomized, two-period, tw...
Anomalous Separation of Small Y-Chromosomal DNA Fragments on Microchip Electrophoresis [0.03%]
微芯片电泳中Y染色体DNA小片段的反常分离现象研究
Mohammad Jabasini,Ashraf Ewis,Youichi Sato et al.
Mohammad Jabasini et al.
We investigated an anomalous DNA separation where two DNA fragments from the human Y-chromosome sY638 (64 bp) and sY592 (65 bp), with only one base pair difference, were separated. This result is abnormal since in a previous study, we found...
The Study of Structure-Analgesic Activity Relationships in a Series of 4-Hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylic Acid Toluidides and Xylidides [0.03%]
一类对氨苯甲基及对硝基苯甲基4-羟基-2，2-二氧代-1H-2λ6，1-苯并噻唑-3-羧酸酯类镇痛作用与结构关系的研究
Igor V Ukrainets,Lidiya A Petrushova,Lyudmila V Sidorenko et al.
Igor V Ukrainets et al.
In continuing the search for new analgesics among derivatives of 2,1-benzothiazines, a series of corresponding toluidides and xylidides of 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylic acid has been synthesized by the reaction o...
Benzotriazole-Mediated Synthesis and Antibacterial Activity of Novel N-Acylcephalexins [0.03%]
新型N-酰基cephalexin的合成及其抗菌活性研究 benzotriazole介导法
Khalid A Agha,Nader E Abo-Dya,Tarek S Ibrahim et al.
Khalid A Agha et al.
Cephalexin (1) was acylated using N-acylbenzotriazoles (3a-k') derived from various carboxylic acids including aromatic, heterocyclic and N-Pg-α-amino acid to afford N-acylcephalexins in excellent yields (82%-96%). Antibacterial screening ...