Optimization of levan biosynthesis from Bacillus siamensis using batch and continuous stirred-tank bioreactors: A response surface methodology approach [0.03%]
响应面法优化枯草芽孢杆菌胞液多糖的分批发酵和连续发酵条件
Pongtorn Phengnoi,Nuttinee Teerakulkittipong,Kosin Teeparuksapun et al.
Pongtorn Phengnoi et al.
Levan, a promising fructan polysaccharide for biopharmaceuticals, has limited large-scale production studies. This research optimized and scaled up levan biosynthesis from Bacillus siamensis in continuous stirred-tank bioreactors based on r...
Prioritizing repurposable drugs for Alzheimer's disease using network-based analysis with concurrent assessment of Long QT syndrome risk [0.03%]
基于网络的阿尔茨海默病再定位药物筛选及其诱发长QT综合症的风险评估
Alessio Funari,Enrico De Smaele,Paola Paci et al.
Alessio Funari et al.
Alzheimer's disease affects 6.9 million Americans aged 65 and older, a number expected to double by 2060. Eight FDA-approved drugs target Alzheimer's, but no cure is available, and most treatments are symptomatic. Drug repurposing, the use ...
Methylene blue removal using alginate-PVA- Pseudomonas aeruginosa biocomposite: Kinetics and biodegradation studies [0.03%]
利用海藻酸盐-PVA-铜绿假单胞菌生物复合材料去除亚甲基蓝：动力学和生物降解研究
Silvia Abdi Pratama,Adi Setyo Purnomo,Asranudin Asranudin
Silvia Abdi Pratama
Methylene blue (MB) is a common synthetic dye used in various industries due to its abundance and cost-effectiveness. However, the presence of this synthetic dye in industrial wastewater has the potential to cause significant effects on the...
Enhancement of the duckweed biomass and starch production utilizing biogenic MnO and ZnO microparticles [0.03%]
利用生物源MnO和ZnO微粒强化水绵生物质及淀粉的生成
Maryam Anar,Sajjad Kamal Shuvro,Muhammad Farooq Hussain Munis et al.
Maryam Anar et al.
The effects of biologically synthesized MnO and ZnO microparticles (MPs), were evaluated on the growth of Lemna minor. Both MnO and ZnO MPs promoted the growth of L. minor at low concentrations of 1-8 mg/L. In contrast, 1000 mg/L MnO and Zn...
Enhancing cell characterization with microfluidics and AI: a comprehensive review of mechanical, electrical, and hybrid techniques [0.03%]
微流控和AI增强细胞表征：机械、电学及混合技术全面回顾
Marwan Taha,Anna-Maria Pappa,Hani Saleh et al.
Marwan Taha et al.
This paper examines recent advancements in cell characterization using microfluidic devices, emphasizing mechanical, electrical, and hybrid methodologies. These technologies have substantially improved throughput, precision, and the range o...
Investigation and optimization of DNA isolation efficiency using ferrite-based magnetic nanoparticles [0.03%]
基于铁基磁性纳米颗粒的DNA提取效率的研究与优化
Tímea B Gerzsenyi,Ágnes M Ilosvai,Ferenc Kristály et al.
Tímea B Gerzsenyi et al.
DNA isolation is a crucial step in many molecular biological applications for diagnostic and research purposes, like detection of infectious diseases or gene expression studies. However, due to the requirement of toxic reagents in tradition...
Integrative analysis of RAS signaling effectors reveals stage-dependent oncogenic patterns in colon adenocarcinoma [0.03%]
整合分析RAS信号转导分子效应物揭示结肠腺癌中阶段依赖性的致癌模式
Loretta László,Anna Lovrics,Álmos Tilajka et al.
Loretta László et al.
Cancer rarely results from a single gene defect but emerges from disruptions in complex cellular networks. The Network Medicine perspective guides our investigation of cancer-driving interactions, particularly focusing on RAS signaling path...
Cultivation of Cupriavidus necatorstrains on hydrolyzed lignocellulosic feedstocks widely available in Europe [0.03%]
欧洲各地广泛存在的木质纤维素原料的水解物培养库瓦式梭菌亚种氮化细菌(strains)
Halima Aliyu Alhafiz,Karin Longus,Rob A J Verlinden et al.
Halima Aliyu Alhafiz et al.
Today, 85 % of the carbon in organic chemicals and their derivatives comes from fossil sources. Replacing fossil-based materials with sustainable sources requires large quantities of feedstocks and mature technologies. Biorefineries based o...
Scale-down optimization of a robust, parallelizable human induced pluripotent stem cell bioprocess for high-throughput research [0.03%]
一种稳健且可并行化的诱导多能干细胞生物工艺的缩放优化以用于高通量研究
James Colter,Tiffany Dang,Julia Malinovska et al.
James Colter et al.
Human induced pluripotent stem cell (hiPSC) derived therapeutics require clinically relevant quantities of high-quality cell populations for applications in regenerative medicine. The lack of efficacy exhibited across clinical trials sugges...
Induction conditions that promote the effect of glycerol on recombinant protein production in Escherichia coli [0.03%]
甘油对大肠杆菌中重组蛋白生产影响的诱导条件研究
Yoshihiro Ojima,Hajime Saito,Shintaro Miyuki et al.
Yoshihiro Ojima et al.
Proinsulin was expressed by Escherichia coli SHuffle T7 with pET system in minimal medium containing glucose (Glu medium), glucose and glycerol (GluGly medium) or glycerol (Gly medium). With 100 μM IPTG, proinsulin production did not incre...