Massive caffeine overdose with extremely high blood caffeine concentration and prolonged toxidrome [0.03%]
大剂量咖啡因中毒伴极高血浆咖啡因浓度和长时间毒物药理表型
Yuka Okazaki,Suguru Hitomi,Shigemasa Taguchi et al.
Yuka Okazaki et al.
The easy availability of caffeine has led to an increased risk of ingesting toxic levels in recent years. Although several studies reported severe and fatal cases of massive caffeine poisoning, few cases of caffeine overdose with a protract...
Investigating a novel solid-state oxygenating therapeutic: Influence on oxidative stress and cellular responses in human lung cells [0.03%]
一种新型固体材料类携氧药物的研究及其对人肺细胞氧化应激和细胞反应的影响
Ashleigh A Jarrous,Asha Ashraf,Sini Macheri et al.
Ashleigh A Jarrous et al.
Hypoxia is a common pathological state found in a diverse array of diseases, including those associated with pulmonary dysfunctions such as ARDS, COPD, and emphysema. BaylorOx is a novel solid-state oxygenating therapeutic that aims to supp...
Cytotoxic and oxidative effects of commercially available propylene glycol (PG) and vegetable glycerin (VG): Common humectants in electronic cigarettes [0.03%]
商用丙二醇(PG)和植物甘油(VG):电子烟中常见的保湿剂的细胞毒性和氧化效应
Yehao Sun,Gagandeep Kaur,Felix Effah et al.
Yehao Sun et al.
The effects of commercially available brands of common e-liquid humectants - propylene glycol (PG) and vegetable glycerin (VG) are not known. This study evaluates the toxicities of commercially available PG and VG mixtures compared to their...
Lemborexant overdose presenting with mild sedation despite high plasma levels: A case report [0.03%]
一例高血药浓度下仅表现为轻度镇静反应的lemborexant中毒病例报告
Makoto Suzuki,Daisuke Usuda,Hiroki Takami et al.
Makoto Suzuki et al.
Introduction: Lemborexant is a dual orexin receptor antagonist (DORA) with a favorable safety profile at therapeutic doses. However, clinical data regarding its toxic effects in overdose scenarios are limited. This is the...
Collateral damage: Cardiovascular and respiratory implications of tear gas deployment during peaceful protest [0.03%]
防暴催泪气体的意外伤害：和平抗议期间部署催泪瓦斯对心血管系统和呼吸系统的潜在影响
Konstantine Chakhunashvili,Gela Gunashvili,Nino Jobava et al.
Konstantine Chakhunashvili et al.
Background: In December 2024, large-scale protests in front of Georgia's Parliament were met with crowd-control measures involving the widespread use of tear gas and pepper spray, mixed with water. This study examined whe...
Amino alkyl-alkyl/aryl sulphides (DRDE-07 and analogues) as promising cytoprotectants for sulphur and nitrogen mustards - A review [0.03%]
氨基烷基-烷基/芳族硫醚（DRDE-07和类似物）作为芥子气和氮芥的有前途的细胞保护剂-综述
R Vijayaraghavan,M Sharma
R Vijayaraghavan
Several antidotes and medical countermeasures were experimented for the protection of one of the notorious chemical warfare agents, the mustard gas, also known as sulphur mustard (SM). Among them, the DRDE series of compounds (amino alkyl-a...
A case series of hyperthermia crisis in cough mixture ingestion: Why early cooling save lives [0.03%]
儿童过量服用止咳糖浆的高热危象系列案例——为何早期降温可以救命
Hon Chun,Tin Yat Anthony Chow
Hon Chun
Objective: Hyperthermia (core body temperature >40°C) associated with cough mixture ingestion has been reported in case studies. However, clinical data and consensus on treatment remain limited. This study aimed to ident...
Pervasive food contaminant ochratoxin-A induces energy crisis: Mitochondrial dysfunction in human primary proximal tubule cells [0.03%]
遍布的食物污染物赭曲霉素A诱导能量危机：人类原发性近端小管细胞线粒体功能障碍
Anish Mahadeo,Theo K Bammler,James MacDonald et al.
Anish Mahadeo et al.
Ochratoxin-A (OTA) is a ubiquitous mycotoxin contaminant in food products and a known nephrotoxin that is not currently regulated in the United States. OTA is hypothesized to be a potential environmental agent causing chronic kidney disease...
Contamination level and dietary risk assessment of trace elements in Brassica pekinensis Lour. from gardening areas under tropical conditions [0.03%]
热带地区温室栽培白菜中微量元素的污染水平及膳食风险评估
Anaïs M Kipelo,Masi Jothilakshmi,Dhafer M M Al Salah et al.
Anaïs M Kipelo et al.
This study examined the levels of trace elements in Brassica pekinensis Lour. collected from urban gardening sites (Cecomaf and Lutendele) in Kinshasa (Democratic Republic of the Congo) and associated potential human health risks for the co...
Attenuation of cerebral ischemia-reperfusion induced neurotoxicity by telmisartan, ertugliflozin, and omaveloxolone through Nrf2/HO-1 pathway modulation: In vivo and in silico insights [0.03%]
通过Nrf2/HO-1通路调节 attenuation cerebral ischemia-reperfusion诱导的神经毒性 in vivo和in silico见解.telmisartan，ertugliflozin和omaveloxolone的作用：
Yasser J H Alyassery,Ahsan F Bairam,Carlos Medina Martin
Yasser J H Alyassery
Ischemia-reperfusion (IR) injury in the brain is a major cause of brain damage and neurotoxicity, particularly in patients with hypertension and diabetes, where oxidative stress and inflammation play critical roles. This study investigated ...