Warfarin-Durian interaction: A case study bridging clinical outcomes and metabolic profiling through metabolomics [0.03%]
warfarin与榴莲的相互作用：通过代谢组学连接临床结局和代谢谱的案例研究
Natthapat Hiranchatchawal,Konwalin Wannaphueak,Piyapat Rattanasuwan et al.
Natthapat Hiranchatchawal et al.
Warfarin-food interactions present significant challenges in achieving optimal anticoagulation; however, comprehensive research remains limited. This preliminary study explores possible mechanisms underlying the effects of durian consumptio...
Fatal nicotine poisoning with an extremely high first available serum nicotine concentration and serial nicotine/cotinine measurements: A case report [0.03%]
一起因尼古丁致死的急性中毒首诊血清尼古丁浓度极高且有连续检测数据的病例报告
Yuka Miyazaki,Jun Monma-Otaki,Sanae Kanno et al.
Yuka Miyazaki et al.
Human toxicokinetic data after massive nicotine exposure are scarce, and the relationship between circulating nicotine kinetics and organ-specific pathophysiology remains poorly understood, particularly in the post-cardiac arrest setting. W...
In vivo toxicity of Dioctyl Phthalate in adult and zebrafish larvae [0.03%]
邻苯二甲酸二辛酯在成体和斑马鱼水溞中的体内毒性作用研究
Ali Rezazadeh,Jalal Hassan,Ali Pourshaban-Shahrestani et al.
Ali Rezazadeh et al.
Dioctyl phthalate (DOP), a widely used plasticizer in flexible plastics, was evaluated for acute toxicity in zebrafish (Danio rerio) embryos and adults as a vertebrate model. Embryos were exposed to 1.0-300 mg/L DOP following OECD guideline...
Microplastics and male reproductive system: A comprehensive review based on cellular and molecular effects [0.03%]
微塑料与男性生殖系统：基于细胞和分子效应的全面综述
Mohammad Karimian,Sahar Yaqubi
Mohammad Karimian
Microplastics (MPs) have emerged as an important environmental challenge and can threaten human health. These particles can enter the human body through food consumption, breathing and even skin absorption and cause disruption in the functi...
Evaluation of the safety of high-dose Lactobacillus gasseri CP2305 supplementation in healthy adults: A randomized, double-blind, placebo-controlled study [0.03%]
鼠李糖乳杆菌CP2305高剂量摄入的安全性评价：一项随机、双盲、安慰剂对照研究
Hajime Fuchida,Daisuke Sawada,Tatsuhiko Hirota et al.
Hajime Fuchida et al.
Objective: Lactobacillus gasseri CP2305 (L. gasseri CP2305) has been reported to exert intestinal regulatory, anti-stress, and sleep-improving effects in healthy adults. This study aimed to evaluate the safety of an exces...
Comparative hepatoprotective effects of Benzene Sulfonamide Derivatives in a rat model of ethylene glycol-induced liver injury [0.03%]
一类苯磺酰胺衍生物的肝保护作用比较及机制研究
Ahmed M Elgendy,Rasha A Al-Eisa,Zohour I Nabil et al.
Ahmed M Elgendy et al.
Ethylene glycol (EG), an alcohol derivative, is metabolized into toxic compounds contributing to liver damage. This study investigated the therapeutic potential of two benzene sulfonamide derivatives-SBCL and SBF-against EG-induced hepatoto...
Sarah A Stevens,Scott H Edwards,Glenys K Noble et al.
Sarah A Stevens et al.
Introduction: As part of a larger study to assess the potential value of industrial hemp biomass (the low Δ9-tetrahydrocannabinol (Δ9-THC) variety of Cannabis sativa L.) as a feed for ruminants, a pharmacokinetics study...
Chronic (180-day) and sub-chronic (90-Day) oral toxicity studies of a novel polyethyleneglycol (PEG)-carbohydrate-lipid conjugate in Wistar rats and beagle dogs [0.03%]
新型聚乙二醇(peg)-多糖-脂质缀合物在Wistar大鼠和比格犬中的慢性（180天）和亚慢性（90天）经口毒性研究
Nian Wu,Siva Rama Krishna Nutalapati,Lacarya Scott et al.
Nian Wu et al.
The toxicity of a new synthetic PEG-carbohydrate-lipid conjugate; 3,3-oleoyl-monomethoxy-polyethyleneglycol (n = 12 mean) ether-propanediamino-lactobionate or Oleoylpropane-diaminododecaethyleneglycolmonomethoxy ether-lactobionate ("DOPS-F0...
Unveiling melatonin's multifaceted actions against ferroptotic neurotoxicity in ischemic stroke [0.03%]
褪黑素对抗缺血性卒中铁死亡神经毒性的多重作用机制
Soraya Boonmag,Russel J Reiter,Piyarat Govitrapong
Soraya Boonmag
Ferroptosis, an iron-mediated form of programmed cell death, is increasingly recognized for its role in neurodegenerative diseases, with relevance to ischemic stroke, a condition that creates a permissive environment for this process. The p...
Telmisartan protects male reproductive function by modulating biochemical, oxidative stress, apoptosis, and DNA integrity in cyclophosphamide-exposed rats [0.03%]
替米沙坦通过调节生物化学、氧化应激、凋亡和DNA完整性来保护环磷酰胺暴露大鼠的雄性生殖功能
Ahmed Ageeb Kassid,Ahmed Mohammed Mahmood,Khalid Ali Obaid et al.
Ahmed Ageeb Kassid et al.
Background: Cyclophosphamide (CPA) is a common chemotherapy drug known to cause significant damage to testicular health. It induces oxidative stress, inflammation, cell death, and DNA damage. Telmisartan blocks the angiot...