Synthetic biology of oncolytic bacteria: Comparative microbial chassis and precise killing strategies [0.03%]
溶瘤细菌合成生物学：比较微生物底盘和精确杀伤策略
Mustafa Attiyah Hadid,Nawfal Haitham Al Shaikhli,Omar Khalid Suhail et al.
Mustafa Attiyah Hadid et al.
The field of synthetic biology has become a revolutionary tool for engineering microorganisms capable of precise, programmed cancer treatment. Unlike conventional cancer treatments, which lack safe, selective toxicity, engineered microbial ...
Effects of dinotefuran and its metabolites on the early life stage development of medaka (Oryzias latipes): In vivo and in silico studies [0.03%]
新型杀虫剂哒硝菌酯及其代谢物对斑马鱼(Oryziaslatipes)早期发育影响的体内和体外研究
Masashi Hirano,Daishi Inoue,Masaya Uchida et al.
Masashi Hirano et al.
Dinotefuran (DINO), a widely used neonicotinoid insecticide, has attracted significant attention because of its environmental risks. Although DINO is metabolized in the environment, its specific toxicological risks remain unclear. In this s...
Silymarin attenuates oxidative, inflammatory and apoptotic damage induced by a fungicide mixture in rat liver, kidney and brain [0.03%]
奶蓟素减轻 fungicide混合物诱导的大鼠肝脏、肾脏和大脑的氧化损伤、炎症损伤和凋亡损伤
Hamada S Salem,Asmaa M R Gouda,Nesreen M Essam et al.
Hamada S Salem et al.
Fungicide exposure is associated with significant health hazards in both animals and humans. The present study examined the toxicological effects of a mixture of copper oxychloride, propiconazole, boscalid, and pyraclostrobin on the liver, ...
Acute toxicity assessment and metabolomic profiling of Taxus sumatrana leaf extract as a sustainable alternative to bark harvesting [0.03%]
一种从赤道红豆杉树叶中提取物的急性毒性评估和代谢组学分析作为从树皮采集的安全替代品
Pamungkas Rizki Ferdian,Wanda Kuswanda,Hadi Sukardi Alikodra et al.
Pamungkas Rizki Ferdian et al.
Taxus sumatrana (Taxaceae) is an Indonesian endemic species known for its anticancer activity due to taxane derivatives. Despite its pharmacological importance, T. sumatrana remains underexplored, and its populations are increasingly threat...
Lycopene supplementation during pregnancy and lactation attenuates thermally oxidized cooking oil-induced hepatic and cerebral damage in rat offspring: A comprehensive histomorphometric and molecular analysis [0.03%]
番茄红素补充剂对妊娠和哺乳期间热氧化烹饪油诱导的大鼠后代肝脑损伤的缓解作用：全面的组织形态学和分子分析
Ahmad Aulia Jusuf,Fadilah,Nimas Ayu Nirwanti
Ahmad Aulia Jusuf
Background: Thermally oxidized cooking oil (TOCO) generates reactive oxygen species and lipid peroxidation products that cross the placental barrier, posing risks to offspring organ development in low-to-middle income cou...
Kelulut honey (Heterotrigona itama) as a multi-target neuroprotective strategy against bisphenol A-induced neurotoxicity [0.03%]
以 Kelulut 蜂蜜作为多靶点神经保护策略对抗双酚A诱导的神经毒性
Siti Khadijah Azmi,Nur Faizah Ali,Rosfaiizah Siran
Siti Khadijah Azmi
Bisphenol A (BPA) is a synthetic chemical widely used in the production of plastics and epoxy resins due to its low cost, durability, and heat resistance.Recognised as an endocrine-disrupting chemical, BPA has raised growing concern regardi...
Toxic exposure and kidney function: Urinary creatinine and glomerular filtration rate in traditional sulfur miners [0.03%]
有毒物暴露与肾功能：传统硫矿工人尿肌酐和肾小球滤过率
Septian Hadi Susetyo,Azham Umar Abidin,Taiki Nagaya et al.
Septian Hadi Susetyo et al.
The Ijen Crater Volcano, recognized by UNESCO as a biosphere reserve, has a high sulfur content and is the main source of traditional sulfur mining work. However, exposure to natural sulfur in this area can cause health problems, especially...
Acute and sub-chronic oral toxicity evaluation and gut microbiota modulation of indigenous Lactobacillus helveticus strains from Indonesia in rats [0.03%]
源自印度尼西亚的土著乳酸菌肠球菌株在大鼠中的急性亚慢性口服毒性评价和肠道微生态调节作用评估研究
Hery Kristiana,Medicia Kartawijaya,Lita Tuentifiany et al.
Hery Kristiana et al.
Probiotics are widely used to support gastrointestinal health, but their safety must be evaluated on a strain-specific basis. Lactobacillus helveticus DLBSA201 and DLBSA202 are indigenous strains with previously demonstrated probiotic poten...
Assessment of genomic instability using the CBMN cytome assay in mother-newborn pairs prenatally exposed to pesticides in Colombia [0.03%]
哥伦比亚孕期接触农药的母子对的CBMN细胞基因组不稳定性的评估
Shirley Salcedo Arteaga,Ana Peñata Taborda,Sara Soto De Leon et al.
Shirley Salcedo Arteaga et al.
Agricultural communities in northern Colombia face high exposure to pesticides, posing significant health risks, particularly to vulnerable populations such as pregnant women and their developing fetuses. The genotoxic impact of in utero pe...
Investigating the microwave degradation of polypropylene microplastics and their impact on human intestinal cell models [0.03%]
微波降解聚丙烯微塑料及其对人肠细胞模型的影响研究
Raphaela O G Ferreira,Emine Merve Canga,Aoife Gowen et al.
Raphaela O G Ferreira et al.
Humans are inevitably exposed to microplastics (MPs) through various pathways, with ingestion being a primary route. Polypropylene (PP), commonly used for food storage and microwave (MW) heating, has the potential to release MPs when expose...