Comprehensive sub-chronic toxicological profiling of illegal artisanal small-scale mining-polluted river bodies in four regions of Ghana [0.03%]
加纳四个地区非法手工小型采矿污染河流的全面亚慢性毒理学特征分析
Du-Bois Asante,George Yaw Hadzi,Samuel Naaman et al.
Du-Bois Asante et al.
Illegal artisanal mining, or 'Galamsey', in Ghana poses serious public health risks by contaminating water bodies with toxic heavy metals. This study assessed the sub-chronic toxicological effects of mining-polluted rivers in four Ghanaian ...
Safety evaluation of an effervescent curcuminoids-ascorbic acid-polysaccharide-β-cyclodextrin (CUR-A-Poly-β-CD) inclusion complex powder in healthy volunteers: A non-placebo-controlled pilot study [0.03%]
姜黄素茋维生素C多糖-β-环糊精包合物固体饮料I期临床安全性评价非盲法试点研究
Chanatip Pramvichai,Wariya Mongkolwat,Siripat Aluksanasuwan et al.
Chanatip Pramvichai et al.
Colorectal cancer (CRC) is a prevalent and aggressive malignancy with a high mortality rate. Although chemotherapy can improve survival outcomes, it is frequently associated with undesirable side effects. Curcuminoids, the principal polyphe...
Establishment of the Kuwait Poison Control Center: From concept to operations [0.03%]
从理念到运营：科威特中毒控制中心的建立
Abdullatif Aloumi,Fatema Alkandari,Muneera Al Asfour et al.
Abdullatif Aloumi et al.
Poisoning is a significant and largely preventable public health problem, encompassing a wide range of exposures that require specialized toxicological expertise. Poison control centers play a key role in healthcare systems by centralizing ...
Comparative analysis of test tube and volumetric drinking monitor methods in voluntary ethanol consumption in female mice for prenatal alcohol exposure [0.03%]
小鼠孕期酒精暴露下自愿摄入乙醇的试管法和量筒法对比分析
Arasely M Rodriguez,Korbin C Bauer,Lee Anna Cunningham
Arasely M Rodriguez
Objective: We directly compared a low-tech test tube (TT) method and a high-tech volumetric drinking monitor (VDM) to assess their impact on female mice alcohol drinking. ...
Tsukasa Tamamori,Keita Tanigaki,Sasaki Naoko et al.
Tsukasa Tamamori et al.
Neonicotinoid pesticides are highly persistent in the environment, with detection in periodontal blood reported. Although an association with gingival inflammation has been shown, the mechanism related to periodontal disease remains unclear...
When herbal supplements cause heart problems: Clinical case report and forensic toxicological analysis [0.03%]
当草药补充剂引起心脏问题时：临床案例报告和法医毒物学分析
Theresa Theuer,Katrin Faber,Lisa Oberli et al.
Theresa Theuer et al.
The global expansion of travel and online supplement markets has eliminated traditional geographic barriers to toxic plant exposures. We report a case of a 42-year-old female presenting with digoxin-like intoxication symptoms, including nau...
Toxicological effects of volatile organic compounds are mediated by aggravated oxidative stress and neuroinflammatory processes in piglets [0.03%]
挥发性有机化合物的毒性作用通过加重氧化应激和神经炎症过程介导：猪模型研究
Evaristus Nwulia,Temitayo Olabisi Ajibade,Charles Etang Onukak et al.
Evaristus Nwulia et al.
Anthropogenic and natural sources of volatile organic compounds (VOCs) have been associated with hematological, cardiovascular, and respiratory diseases. VOCs can also track directly from the nose to the olfactory bulb (OB). This study inve...
Optimization of an ex vivo model to test the ability of chemicals to disrupt thyroid hormone synthesis [0.03%]
优化体外模型以测试化学品干扰甲状腺激素合成的能力
Mikala Melchiors,Mette Stub,Louise Ramhøj et al.
Mikala Melchiors et al.
Thyroid hormone (TH) synthesis and secretion can be perturbed by endocrine disrupting chemicals (EDCs). Traditional 2D cell culture models are useful for studying specific effects on enzymes and transporters involved in hormone synthesis; h...
L-Methionine attenuates methotrexate-induced cardiotoxicity by modulating oxidative stress, inflammation, and dyslipidemia in rats [0.03%]
L-蛋氨酸通过调节氧化应激、炎症和脂质异常减轻大鼠甲氨蝶呤引起的心脏毒性
Wessam M Abdel-Wahab,Nada S Daifalla,Amina E Essawy
Wessam M Abdel-Wahab
Methotrexate (MTX) is a potent chemotherapeutic agent with a wide range of anticancer effects; however, its clinical efficacy is restricted due to its cardiomyopathy. This research examined the protective potential of L-Methionine (L-Met) a...
Current insights into long non-coding RNAs role for insulin resistance emerging in type 2 diabetes mellitus and its complications [0.03%]
长链非编码RNA在2型糖尿病及其并发症中作用的最新见解
Rehab M Abdel-Megeed
Rehab M Abdel-Megeed
Insulin resistance (IR) is a key factor in the development and progression of diabetes and other metabolic disorders. It occurs when insulin target tissues do not respond to normal insulin levels. Further research is needed to identify the ...