Mycoflora, mycotoxin exposure and cancer risk assessment in Tuo-Zaafi, a fermented cereal meal consumed in northern Ghana [0.03%]
加纳吐奥-扎阿菲（发酵谷物食品）中的霉菌、霉菌毒素及其致癌风险评估
Nii Korley Kortei,Amos Adugbire Aduko,Lydia Quansah et al.
Nii Korley Kortei et al.
Tuo zaafi, a traditional dish prepared from cereals and often accompanied by dark green vegetable soup, is a revered dish well known for its medicinal and nutritional attributes. The cereals are usually prone to mycotoxin contamination. Thi...
Regulatory integration of new approach methodologies for human-relevant developmental and reproductive toxicity (DART) assessment: A systematic cross-sector review [0.03%]
人相关发育和生殖毒性(DART)评估的新方法监管整合:系统跨部门回顾
Smita Kumbhar,Shrikant Borude,Rahil Deshmukh
Smita Kumbhar
Developmental and reproductive toxicity (DART) assessment is a critical component of regulatory safety evaluation across pharmaceutical, chemical, environmental, and consumer product sectors. Traditionally, DART testing has relied on animal...
Repeated oral administration of gamma-aminobutyric acid (GABA) does not cause reproductive or developmental toxicity in rats [0.03%]
γ-氨基丁酸(GABA)的重复经口染毒不引起生殖和发育毒性
Xuan Li,Aditya Kulkarni,Hiroaki Yamada et al.
Xuan Li et al.
Gamma-aminobutyric acid (GABA) occurs naturally in a variety of foods and has a long history of dietary consumption, yet its effects on reproduction and development have not been evaluated in a guideline-compliant toxicological study. We ex...
Toxicological profile of anti-diabetic drugs and emerging measures to reduce the toxic burden [0.03%]
抗糖尿病药物的毒理学特征及降低毒性负担的新举措
George J Dugbartey,Karl K Alornyo,Christabel O Dapaa-Addo et al.
George J Dugbartey et al.
Diabetes mellitus (DM) is a major public health concern of the 21st century, with global figures of the diabetic population expected to reach approximately 700 million by 2045. In the face of this rapidly increasing trend in global prevalen...
Ethylene glycol toxicity presenting as a rapidly deteriorating focal neurological exam and reversible cerebral herniation syndrome [0.03%]
乙二醇中毒导致的进行性局灶神经功能缺损和可逆性脑疝综合征病例报告
Andrea L Klein,Hayley H Rose-Inman,Paul E Stromberg et al.
Andrea L Klein et al.
Ethylene glycol toxicity is an exceedingly rare toxic encephalopathy. Ethylene glycol is the primary toxin in antifreeze and exhibits its toxicologic effects via metabolites glycolic and oxalic acids, driving a profound metabolic acidemia. ...
Unravelling the multi-target mechanism of methoxylated flavonoids in Parkinson's disease: Insights from network pharmacology and molecular dynamics [0.03%]
基于网络药理学和分子动力学的帕金森病多靶标甲基化黄酮类化合物作用机制研究
Chetan Ashok,Srikanth Jeyabalan,Parasuraman Pavadai et al.
Chetan Ashok et al.
Current therapy for Parkinson's disease (PD), a neurodegenerative disorder that progresses over time marked by protein aggregation, dopaminergic neuronal death and oxidative stress, only provides symptomatic alleviation. By using an integra...
National survey of Dutch emergency physicians on pharmacological sedation practices for extreme agitation [0.03%]
荷兰急诊医师对重度兴奋的药物镇静实践的全国调查
J J J Ouwerkerk,N Kraaijvanger,N J A van der Wee et al.
J J J Ouwerkerk et al.
Background and importance: Extreme agitation in the emergency department (ED) is a high-risk scenario requiring rapid, safe sedation. International evidence and guidance on first line and rescue agents are variable, howev...
The Venom Revolution in Biomedicine: Unlocking Nature's Toxin Toolkit for Therapeutic Innovation [0.03%]
生物医学的毒液革命：解锁自然毒素工具箱以实现治疗创新
Debalina Bose,Kishore Srinivasan,Sanskruti Shrenik Patil et al.
Debalina Bose et al.
Once known only for its deadly effects, venom is now valued for its medicinal potential. The transformation of venomous substances into therapeutic agents, focusing on the synergy between natural toxins and drugs, is a recent topic of inter...
The autophagy switch: A critical determinant of arsenic-induced carcinogenesis and cancer therapy [0.03%]
自噬调控开关：砷致致癌和癌症治疗的关键因素
Marzieh Zeinvand-Lorestani,Fakher Rahim,Hamed Zeinvand-Lorestani
Marzieh Zeinvand-Lorestani
Arsenic, a widespread environmental toxicant and unexpectedly effective chemotherapeutic agent, has complex and significant effects on cellular homeostasis. Autophagy, a conserved lysosomal degradation process, plays a key role in arsenic's...
Supalak Kongsri,Chunyapuk Kukusamude
Supalak Kongsri
Concentrations of cadmium (Cd) in 46 jasmine rice samples were measured by inductively coupled plasma mass spectrometer (ICP-MS). The rice samples were digested using microwave-assisted acid digestion prior to ICP-MS analysis. The recovery ...