Metabolic engineering of Pseudomonas taiwanensis VLB120 for rhamnolipid biosynthesis from biomass-derived aromatics [0.03%]
利用生物质衍生物芳香族化合物进行副胎单胞菌VB120次生代谢产物鼠李糖脂的合成与分泌代谢工程研究
Vaishnavi Sivapuratharasan,Christoph Lenzen,Carina Michel et al.
Vaishnavi Sivapuratharasan et al.
Lignin is a ubiquitously available and sustainable feedstock that is underused as its depolymerization yields a range of aromatic monomers that are challenging substrates for microbes. In this study, we investigated the growth of Pseudomona...
Development of a dedicated Golden Gate Assembly Platform (RtGGA) for Rhodotorula toruloides [0.03%]
用于Rhodotorula toruloides的专用Golden Gate组装平台（RtGGA）开发
Nemailla Bonturi,Marina Julio Pinheiro,Paola Monteiro de Oliveira et al.
Nemailla Bonturi et al.
Rhodotorula toruloides is a potential chassis for microbial cell factories as this yeast can metabolise different substrates into a diverse range of natural products, but the lack of efficient synthetic biology tools hinders its applicabili...
Control of D-lactic acid content in P(LA-3HB) copolymer in the yeast Saccharomyces cerevisiae using a synthetic gene expression system [0.03%]
利用合成基因表达系统控制酵母中的D-型乳酸含量以调节P(LA-3HB)共聚物的组成
Anna Ylinen,Laura Salusjärvi,Mervi Toivari et al.
Anna Ylinen et al.
The fully biobased polyhydroxyalkanoate (PHA) polymers provide interesting alternatives for petrochemical derived plastic materials. The mechanical properties of some PHAs, including the common poly(3-hydroxybutyrate) (PHB), are limited, bu...
Dina Kačar,Carmen Schleissner,Librada M Cañedo et al.
Dina Kačar et al.
Pederin is a potent polyketide toxin that causes severe skin lesions in humans after contact with insects of genus Paederus. Due to its potent anticancer activities, pederin family compounds have raised the interest of pharmaceutical indust...
Engineering of Yarrowia lipolytica for the production of plant triterpenoids: Asiatic, madecassic, and arjunolic acids [0.03%]
工程改造圆褐固氮酵母用于生产植物三萜酸：齐墩果酸、尿苏酸和阿贾那酸
Jonathan Asmund Arnesen,Arian Belmonte Del Ama,Sidharth Jayachandran et al.
Jonathan Asmund Arnesen et al.
Several plant triterpenoids have valuable pharmaceutical properties, but their production and usage is limited since extraction from plants can burden natural resources, and result in low yields and purity. Here, we engineered oleaginous ye...
Development of an E. coli-based norbaeocystin production platform and evaluation of behavioral effects in rats [0.03%]
大肠杆菌次 Boehemicyn 生产平台的开发及对大鼠行为的影响评价
Alexandra M Adams,Nicholas A Anas,Abhishek K Sen et al.
Alexandra M Adams et al.
Interest in the potential therapeutic efficacy of psilocybin and other psychedelic compounds has escalated significantly in recent years. To date, little is known regarding the biological activity of the psilocybin pathway intermediate, nor...
De novo biosynthesis of diverse plant-derived styrylpyrones in Saccharomyces cerevisiae [0.03%]
从头合成多种来源于植物的茋衍生物 Styrylpyrones 在酿酒酵母中合成多种植物衍生的styrylpyrone化合物
Yinan Wu,Maple N Chen,Sijin Li
Yinan Wu
Plant styrylpyrones exerting well-established neuroprotective properties have attracted increasing attention in recent years. The ability to synthesize each individual styrylpyrone in engineered microorganisms is important to understanding ...
Application of metabolic engineering to enhance the content of alkaloids in medicinal plants [0.03%]
代谢工程学在提高药用植物生物碱含量方面的应用
Soledad Mora-Vásquez,Guillermo Gael Wells-Abascal,Claudia Espinosa-Leal et al.
Soledad Mora-Vásquez et al.
Plants are a rich source of bioactive compounds, many of which have been exploited for cosmetic, nutritional, and medicinal purposes. Through the characterization of metabolic pathways, as well as the mechanisms responsible for the accumula...
Thermodynamics contributes to high limonene productivity in cyanobacteria [0.03%]
热力学有助于蓝藻中柠檬烯高产量的产生
Shrameeta Shinde,Sonali Singapuri,Zhenxiong Jiang et al.
Shrameeta Shinde et al.
Terpenoids are a large group of secondary metabolites with broad industrial applications. Engineering cyanobacteria is an attractive route for the sustainable production of commodity terpenoids. Currently, a major obstacle lies in the low p...
Production of human milk fat substitute by engineered strains of Yarrowia lipolytica [0.03%]
产脂肪毕赤酵母工程菌株用于生产人类乳脂替代品
Govindprasad Bhutada,Guillaume Menard,Rupam Kumar Bhunia et al.
Govindprasad Bhutada et al.
Human milk fat has a distinctive stereoisomeric structure where palmitic acid is esterified to the middle (sn-2) position on the glycerol backbone of the triacylglycerol and unsaturated fatty acids to the outer (sn-1/3) positions. This conf...