Micaela Chacón,Neil Dixon
Micaela Chacón
Current plastic production and consumption routes are unsustainable due to impact upon climate change and pollution, and therefore reform across the entire value chain is required. Biotechnology offers solutions for production from renewabl...
From plastic waste to bioprocesses: Using ethylene glycol from polyethylene terephthalate biodegradation to fuel Escherichia coli metabolism and produce value-added compounds [0.03%]
从塑料废弃物到生物过程：利用聚对苯二甲酸乙二醇酯生物降解产生的乙二醇来为大肠杆菌代谢供能并生产高附加值化合物
Alexandra Balola,Sofia Ferreira,Isabel Rocha
Alexandra Balola
Polyethylene Terephthalate (PET) is a petroleum-based plastic polymer that, by design, can last decades, if not hundreds of years, when released into the environment through plastic waste leakage. In the pursuit of sustainable solutions to ...
Cutting-edge developments in plastic biodegradation and upcycling via engineering approaches [0.03%]
工程学视角下塑料生物降解及升级回收的最新研究进展
Zeinab Rezaei,Amir Soleimani Dinani,Hamid Moghimi
Zeinab Rezaei
The increasing use of plastics has resulted in the production of high quantities of plastic waste that pose a serious risk to the environment. The upcycling of plastics into value-added products offers a potential solution for resolving the...
Selective production of the itaconic acid-derived compounds 2-hydroxyparaconic and itatartaric acid [0.03%]
从衣康酸衍生的2-羟基巴金酸和衣塔酒石酸的选择性合成
Philipp Ernst,Felicia Zlati,Larissa Kever et al.
Philipp Ernst et al.
There is a strong interest in itaconic acid in the medical and pharmaceutical sectors, both as an anti-bacterial compound and as an immunoregulator in mammalian macrophages. Fungal hosts also produce itaconic acid, and in addition they can ...
Reconstruction and analyses of genome-scale halomonas metabolic network yield a highly efficient PHA production [0.03%]
泛基因组规模的卤单胞菌代谢网络重建与分析揭示了一种高效的PHA生产途径
Luhui Zhang,Xinpei Sun,Jianwen Ye et al.
Luhui Zhang et al.
In pursuit of reliable and efficient industrial microbes, this study integrates cutting-edge systems biology tools with Halomonas bluephagenesis TD01, a robust halophilic bacterium. We generated the complete and annotated circular genome se...
Tuning the performance of a TphR-based terephthalate biosensor with a design of experiments approach [0.03%]
基于实验设计的TphR生物传感器对苯二甲酸性能的调节
Guadalupe Alvarez Gonzalez,Micaela Chacón,Thomas Butterfield et al.
Guadalupe Alvarez Gonzalez et al.
Transcription factor-based biosensors are genetic tools that aim to predictability link the presence of a specific input stimuli to a tailored gene expression output. The performance characteristics of a biosensor fundamentally determines i...
Metabolic engineering of Acinetobacter baylyi ADP1 for naringenin production [0.03%]
用于柚皮素生产的阿 Klebsiella oxytoca 代谢工程菌株的开发
Kesi Kurnia,Elena Efimova,Ville Santala et al.
Kesi Kurnia et al.
Naringenin, a flavanone and a precursor for a variety of flavonoids, has potential applications in the health and pharmaceutical sectors. The biological production of naringenin using genetically engineered microbes is considered as a promi...
PEZy-miner: An artificial intelligence driven approach for the discovery of plastic-degrading enzyme candidates [0.03%]
一种人工智能驱动的发现降解塑料候选酶的方法PEZy-miner
Renjing Jiang,Zhenrui Yue,Lanyu Shang et al.
Renjing Jiang et al.
Plastic waste has caused a global environmental crisis. Biocatalytic depolymerization mediated by enzymes has emerged as an efficient and sustainable alternative for plastic treatment and recycling. However, it is challenging and time-consu...
Ryosuke Mitsui,Akihiko Kondo,Tomokazu Shirai
Ryosuke Mitsui
The budding yeast, Saccharomyces cerevisiae, has a high tolerance to organic acids and alcohols, and thus grows well under toxic concentrations of various compounds in the culture medium, potentially allowing for highly efficient compound p...
Engineering thioesterase as a driving force for novel itaconate production via its degradation scheme [0.03%]
通过硫酯酶的降解机制工程化硫酯酶以驱动新型衣康酸生物制造
Ryan S Wang,Siang-Wun Siao,Jessica C Wang et al.
Ryan S Wang et al.
Incorporation of irreversible steps in pathway design enhances the overall thermodynamic favorability and often leads to better bioconversion yield given functional enzymes. Using this concept, here we constructed the first non-natural itac...