Excessive by-product formation: A key contributor to low isobutanol yields of engineered Saccharomyces cerevisiae strains [0.03%]
副产物的过度生成：工程酵母异丁醇产量低的主要原因
N Milne,S A Wahl,A J A van Maris et al.
N Milne et al.
It is theoretically possible to engineer Saccharomyces cerevisiae strains in which isobutanol is the predominant catabolic product and high-yielding isobutanol-producing strains are already reported by industry. Conversely, isobutanol yield...
Liposomes modified with cardiolipin can act as a platform to regulate the potential flux of NADP+-dependent isocitrate dehydrogenase [0.03%]
角鲨烯前体药物递送系统中角鲨烯的药代动力学行为及其与递送效率的关系
Keishi Suga,Akari Hamasaki,Junpei Chinzaka et al.
Keishi Suga et al.
Cardiolipin (CL) is a phospholipid found in the outer mitochondrial membrane (OMM) and inner mitochondrial membrane (IMM) in animal cells. Isocitrate dehydrogenase (ICDH) is an important catalytic enzyme that is localized at the cytosol and...
Flux Balance Analysis Indicates that Methane Is the Lowest Cost Feedstock for Microbial Cell Factories [0.03%]
通量平衡分析表明甲烷是微生物细胞工厂中成本最低的原料
Austin D Comer,Matthew R Long,Jennifer L Reed et al.
Austin D Comer et al.
The low cost of natural gas has driven significant interest in using C1 carbon sources (e.g. methane, methanol, CO, syngas) as feedstocks for producing liquid transportation fuels and commodity chemicals. Given the large contribution of sug...
Field trial evaluation of the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Camelina sativa: Making fish oil substitutes in plants [0.03%]
田间试验评估转基因骆驼蓬中欧米伽-3高度不饱和脂肪酸的积累：在植物中制造鱼油替代品
Sarah Usher,Richard P Haslam,Noemi Ruiz-Lopez et al.
Sarah Usher et al.
The global consumption of fish oils currently exceeds one million tonnes, with the natural de novo source of these important fatty acids forming the base of marine foodwebs. Here we describe the first field-based evaluation of a terrestrial...
Microbial production of 1-octanol: A naturally excreted biofuel with diesel-like properties [0.03%]
微生物生产1-辛醇：一种像柴油一样性能的天然分泌生物燃料
M Kalim Akhtar,Hariharan Dandapani,Kati Thiel et al.
M Kalim Akhtar et al.
The development of sustainable, bio-based technologies to convert solar energy and carbon dioxide into fuels is a grand challenge. A core part of this challenge is to produce a fuel that is compatible with the existing transportation infras...
Improvement of glucaric acid production in E. coli via dynamic control of metabolic fluxes [0.03%]
通过代谢流的动态控制改善大肠杆菌中古洛糖酸的生产
Irene M Brockman Reizman,Andrew R Stenger,Chris R Reisch et al.
Irene M Brockman Reizman et al.
D-glucaric acid can be used as a building block for biopolymers as well as in the formulation of detergents and corrosion inhibitors. A biosynthetic route for production in E. coli has been developed (Moon et al., 2009), but previous work w...
Expanding Metabolic Engineering Algorithms Using Feasible Space and Shadow Price Constraint Modules [0.03%]
基于可行域和阴影价格的代谢工程算法拓展研究
Christopher J Tervo,Jennifer L Reed
Christopher J Tervo
While numerous computational methods have been developed that use genome-scale models to propose mutants for the purpose of metabolic engineering, they generally compare mutants based on a single criteria (e.g., production rate at a mutant'...