Anne Gompel,Richard Simcock
Anne Gompel
Breast cancer risk is a central concern in shared decision-making when considering menopausal hormone treatment (MHT). Women spend approximately 40% of their lives in menopause, and climacteric symptoms can substantially impair quality of l...
Temporal changes and genetic susceptibility to type 2 diabetes (1984-2019; HUNT): a longitudinal, population-based study [0.03%]
1984年至2019年 Hunt研究中2型糖尿病的时变特征及其遗传易感性：一项纵向队列研究
Vera Vik Bjarkø,Brooke N Wolford,Eirin B Haug et al.
Vera Vik Bjarkø et al.
Background: The global prevalence of type 2 diabetes has nearly doubled between 1990 and 2020. Genetic susceptibility confers increased risk of type 2 diabetes, but environmental exposures could modify this risk. We aimed...
Lluís Masana,Daiana Ibarretxe
Lluís Masana
Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial [0.03%]
青少年纯合子家族性高胆固醇血症患者inclisiran有效性和安全性的研究（ORION-16）：一项两阶段、随机、多中心临床试验
Albert Wiegman,Amy L Peterson,Eric Bruckert et al.
Albert Wiegman et al.
Background: Inclisiran, a small interfering RNA targeting hepatic PCSK9, was previously studied in various adult patient populations, but it has not yet been assessed in paediatric patients with heterozygous familial hype...
Jiawen Dong,Stefanie Hahner,Irina Bancos et al.
Jiawen Dong et al.
Addison's disease is the manifestation of adrenal glucocorticoid and mineralocorticoid deficiency from T-cell mediated destruction of the adrenal cortex, and is the commonest cause of primary adrenal insufficiency in adults. Due to its vagu...
Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study [0.03%]
手术与保守治疗对双侧肾上腺肿瘤和皮质醇增多症患者心血管结局影响的国际回顾性队列研究
Elisabeth Nowak,Charlotte L Viëtor,Richard A Feelders et al.
Elisabeth Nowak et al.
Background: Treatment for patients with bilateral adrenal tumours and cortisol excess is not standardised and poses a therapeutic dilemma. Untreated cortisol excess is associated with cardiometabolic morbidity and mortali...
More liberal use of bilateral adrenalectomy for bilateral adrenal tumours with cortisol excess [0.03%]
单侧或双侧肾上腺全切术治疗双侧皮质醇增多症肿瘤的效果及安全性分析
Quan-Yang Duh,Michelle B Mulder
Quan-Yang Duh
Feasibility of general population screening for type 1 diabetes in the UK: the ELSA study [0.03%]
英国1型糖尿病全民筛查可行性研究：ELSA研究
Lauren M Quinn,Josephine Elliott,Theodora Papanikolaou et al.
Lauren M Quinn et al.