Jonathan E Shaw,Dianna J Magliano
Jonathan E Shaw
Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis [0.03%]
甲状腺功能亢进的病因、发病机制、诊断、治疗、并发症和预后
Wilmar M Wiersinga,Kris G Poppe,Grigoris Effraimidis
Wilmar M Wiersinga
Hyperthyroidism is a common condition with a global prevalence of 0·2-1·3%. When clinical suspicion of hyperthyroidism arises, it should be confirmed by biochemical tests (eg, low TSH, high free thyroxine [FT4], or high free tri-iodothyon...
Mechanisms of ageing: growth hormone, dietary restriction, and metformin [0.03%]
衰老机制：生长激素、饮食限制和二甲双胍的作用
Jansher Khan,Ida Pernicova,Kiran Nisar et al.
Jansher Khan et al.
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone-insulin-like growth factor 1 (IGF-1) ...
Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study [0.03%]
PCSK1杂合子变异体对肥胖的贡献及其在精准医学中的意义：病例对照研究
Lise Folon,Morgane Baron,Bénédicte Toussaint et al.
Lise Folon et al.
Background: Rare biallelic pathogenic mutations in PCSK1 (encoding proprotein convertase subtilisin/kexin type 1 [PC1/3]) cause early-onset obesity associated with various endocrinopathies. Setmelanotide has been approved...
Anita P Courcoulas
Anita P Courcoulas
Can non-equilibrium thermodynamics explain skeletal muscle insulin resistance due to low mitochondrial content? [0.03%]
非平衡态热力学能解释线粒体含量低引起的骨骼肌胰岛素抵抗吗？
Lawrence J Mandarino,Wayne T Willis
Lawrence J Mandarino
Beyond genetic screening-functionality-based precision medicine in monogenic obesity [0.03%]
超越基因筛查——单基因肥胖的功能性精准医疗
Antje Körner,Robert Stein,Kathrin Landgraf
Antje Körner
The Lancet Diabetes Endocrinology
The Lancet Diabetes Endocrinology
Michael Bergman,Martin Buysschaert,Antonio Ceriello et al.
Michael Bergman et al.
Talha Burki
Talha Burki