Cagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study [0.03%]
在2型糖尿病患者中比较卡格利汀德-索马鲁肽与司美鲁肽或卡格列汀的效果（REIMAGINE 2）：一项双盲、随机、对照的Ⅲ期临床试验
John B Buse,Harpreet S Bajaj,Stine-Mathilde Dalskov et al.
John B Buse et al.
Background: The amylin receptor agonist cagrilintide and the GLP-1 receptor agonist semaglutide have complementary effects on glycaemic control and bodyweight. We aimed to investigate the efficacy and safety of a fixed-do...
The Lancet Diabetes Endocrinology
The Lancet Diabetes Endocrinology
Genetics of pancreatic agenesis: a 21-year international cohort study [0.03%]
胰腺缺如的遗传学：一项为期21年的国际队列研究
Kathryn E Hinton,Sarah E Flanagan,Jayne A L Houghton et al.
Kathryn E Hinton et al.
Mesut Savas,Susanne Kuckuck,Mariëtte R Boon et al.
Mesut Savas et al.
Obesity is increasingly managed with medications as disease-modifying therapies, reflecting its role as a gateway disease driving metabolic, cardiovascular, reproductive, neuropsychiatric, and mechanical conditions. This Review synthesises ...
Effects of a 6-week subcutaneous infusion of native GIP alone or as add-on to semaglutide in people with type 2 diabetes: a single-centre, double-blind, parallel-group, randomised, placebo-controlled trial [0.03%]
为期6周原生GIP亚皮下输注或作为索马鲁肽添加治疗对2型糖尿病患者的效果：一项单中心、双盲、平行分组、安慰剂对照的随机试验
Mads M Helsted,Christiane Fonnesbech-Wulff,Nina L Schaltz et al.
Mads M Helsted et al.
Background: The long-term glycaemic effects of glucose-dependent insulinotropic polypeptide (GIP) remain unclear. We aimed to assess whether a 6-week subcutaneous infusion of GIP alone and in combination with the GLP-1 re...
Type 1 diabetes intervention clusters in resource-limited settings: a systematic review and economic evaluation [0.03%]
资源有限条件下的一型糖尿病干预措施：系统评价与经济性分析
Sanjay Basu,Jessica Hanae Zafra-Tanaka,David Beran
Sanjay Basu
Background: Over 9 million people are living with type 1 diabetes globally, with a disproportionate burden in resource-limited settings where access to care remains constrained. Individual interventions have shown modest ...
Faidon Magkos,Norbert Stefan
Faidon Magkos
Worldwide, approximately half of the general population is actively attempting to lose weight. However, weight loss is typically followed by substantial weight regain, often leading to repeated cycles of loss and gain of bodyweight. Weight ...
Michael G Ziegler
Michael G Ziegler