A Manually Curated Database on Clinical Studies Involving Cell Products Derived from Human Pluripotent Stem Cells [0.03%]
一个关于临床研究的手动整理数据库，涉及由人类多能干细胞衍生的细胞产品
Sabine Kobold,Anke Guhr,Nancy Mah et al.
Sabine Kobold et al.
The last 5 years have witnessed a significant increase in the number of clinical studies based on human pluripotent stem cells (hPSCs). In parallel, concern is increasing about the proliferation of unregulated stem cell treatments worldwide...
UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters [0.03%]
UTX通过解析二价启动子调节人类神经分化和树突形态
Qing-Yuan Tang,Shuang-Feng Zhang,Shang-Kun Dai et al.
Qing-Yuan Tang et al.
UTX, a H3K27me3 demethylase, plays an important role in mouse brain development. However, so little is known about the function of UTX in human neural differentiation and dendritic morphology. In this study, we generated UTX-null human embr...
Intestinal Stem Cell Niche Defects Result in Impaired 3D Organoid Formation in Mouse Models of Crohn's Disease-like Ileitis [0.03%]
克罗恩病小鼠模型肠道干细胞生态位缺陷导致类器官三维重建障碍
Ludovica F Buttó,Adam Pelletier,Shyam K More et al.
Ludovica F Buttó et al.
Intestinal epithelial barrier dysfunction is a risk factor in the pathogenesis of Crohn's disease (CD); however, no corrective FDA-approved therapies exist. We used an enteroid (EnO)-based system in two murine models of experimental CD, SAM...
Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids [0.03%]
皮质脊髓束移植人脑器官轴突延伸的研究
Takahiro Kitahara,Hideya Sakaguchi,Asuka Morizane et al.
Takahiro Kitahara et al.
The reconstruction of lost neural circuits by cell replacement is a possible treatment for neurological deficits after cerebral cortex injury. Cerebral organoids can be a novel source for cell transplantation, but because the cellular compo...
H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline [0.03%]
组蛋白去甲基化酶JMJD1A和JMJD1B调控小鼠生精细胞 prospermatogonia到spermatogonia的过渡过程
Shunsuke Kuroki,Ryo Maeda,Masashi Yano et al.
Shunsuke Kuroki et al.
Histone H3 lysine 9 (H3K9) methylation is dynamically regulated by methyltransferases and demethylases. In spermatogenesis, prospermatogonia differentiate into differentiating or undifferentiated spermatogonia after birth. However, the epig...
Rong Wang,Roshan Sharma,Xiaojuan Shen et al.
Rong Wang et al.
Published Erratum
Stem cell reports. 2020 Jul 14;15(1):275-277. DOI:10.1016/j.stemcr.2020.06.002 2020
Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential [0.03%]
可诱导的前向编程将人体多能干细胞转化为具有血液生成潜能的血细胞内皮祖细胞
Lucas Lange,Dirk Hoffmann,Adrian Schwarzer et al.
Lucas Lange et al.
Published Erratum
Stem cell reports. 2020 Jul 14;15(1):274. DOI:10.1016/j.stemcr.2020.05.019 2020
Gli1+ Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation [0.03%]
Gli1阳性细胞与H型血管偶联，并且对于H型血管的形成是必需的
Ji Chen,Meng Li,An-Qi Liu et al.
Ji Chen et al.
Mesenchymal stem/stromal cells (MSCs) reside in the perivascular niche and modulate tissue/organ homeostasis; however, little is known about whether and how their localization and function are linked. Particularly, whether specific MSC subs...
Arachidonic Acid Promotes Intestinal Regeneration by Activating WNT Signaling [0.03%]
花生四烯酸通过激活Wnt信号促进肠再生
Qingyu Wang,Yingying Lin,Xiaole Sheng et al.
Qingyu Wang et al.
Intestinal regeneration is crucial for functional restoration after injury, and nutritional molecules can play an important role in this process. Here, we found that arachidonic acid (AA) serves as a direct proliferation promoter of intesti...
Human Aging Alters the Spatial Organization between CD34+ Hematopoietic Cells and Adipocytes in Bone Marrow [0.03%]
人类衰老改变了骨髓中CD34+造血细胞与脂肪细胞间的空间分布关系
Alicia G Aguilar-Navarro,Berenice Meza-León,Dita Gratzinger et al.
Alicia G Aguilar-Navarro et al.
Age-related clonal hematopoiesis is a major risk factor for myeloid malignancy and myeloid skewing is a hallmark of aging. However, while it is known that non-cell-autonomous components of the microenvironment can also influence this risk, ...