MiR-126 Regulates Properties of SOX9+ Liver Progenitor Cells during Liver Repair by Targeting Hoxb6 [0.03%]
通过靶向Hoxb6 MiR-126在肝脏修复过程中调控SOX9+肝祖细胞的特性
Yi Yan,Rui Wang,Xiongji Hu et al.
Yi Yan et al.
Liver progenitor cells (LPCs) have a remarkable contribution to the hepatocytes and ductal cells when normal hepatocyte proliferation is severely impaired. As a biomarker for LPCs, Sry-box 9 (Sox9) plays critical roles in liver homeostasis ...
A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells [0.03%]
单剂量的前列腺素E2放射防护剂可阻止辐射诱导的造血干细胞凋亡信号和早期循环
Andrea M Patterson,Liqiong Liu,Carol H Sampson et al.
Andrea M Patterson et al.
Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E2 (dmPGE2) prior to lethal ionizing radiation (IR) facilitates survival, but the cellular and molecular m...
Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease [0.03%]
诱导多能干细胞系统性淀粉样变模型中淀粉样前体运甲状腺蛋白表达推动肝蛋白质稳态重塑
Richard M Giadone,Derek C Liberti,Taylor M Matte et al.
Richard M Giadone et al.
The systemic amyloidoses are diverse disorders in which misfolded proteins are secreted by effector organs and deposited as proteotoxic aggregates at downstream tissues. Although well described clinically, the contribution of synthesizing o...
Bumwhee Lee,Shree Panda,Hye Young Lee
Bumwhee Lee
The primary cilium is the non-motile cilium present in most mammalian cell types and functions as an antenna for cells to sense signals. Ablating primary cilia in postnatal newborn neurons of the dentate gyrus (DG) results in both reduced d...
Putative Mechanisms Underlying Cardiovascular Disease Associated with Clonal Hematopoiesis of Indeterminate Potential [0.03%]
克隆性造血不定潜能可能引起心血管疾病的潜在机制
Sarah S Burns,Reuben Kapur
Sarah S Burns
Characterized by the expansion of somatic mutations in the hematopoietic lineages of aging individuals, clonal hematopoiesis of indeterminate potential (CHIP) is a common condition that increases the risk of developing hematological maligna...
Conversion of Fibroblast into Functional Leydig-like Cell Using Defined Small Molecules [0.03%]
使用特定小分子将成纤维细胞转化为功能性类间质细胞
Yan Yang,Chenxing Zhou,Tiantian Zhang et al.
Yan Yang et al.
Recent studies have demonstrated that fibroblasts can be directly converted into functional Leydig cells by transcription factors. However, the transgenic approach used in these studies raises safety concerns for its future application. Her...
The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver [0.03%]
periostin/integrin-αv轴调节胎儿肝中血液干细胞的数量
Atreyi Biswas,Irene M Roy,Prathibha C Babu et al.
Atreyi Biswas et al.
We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult hematopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of p...
Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem Cells [0.03%]
抗雌激素耐药ALDH+乳腺癌干细胞的特征是白细胞介素-1受体表达增强
Aida Sarmiento-Castro,Eva Caamaño-Gutiérrez,Andrew H Sims et al.
Aida Sarmiento-Castro et al.
Estrogen-receptor-positive breast tumors are treated with anti-estrogen (AE) therapies but frequently develop resistance. Cancer stem cells (CSCs) with high aldehyde dehydrogenase activity (ALDH+ cells) are enriched following AE treatment. ...
Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution [0.03%]
以单细胞分辨率在活体非人灵长类动物中成像移植视网膜感光细胞
Ebrahim Aboualizadeh,M Joseph Phillips,Juliette E McGregor et al.
Ebrahim Aboualizadeh et al.
Stem cell-based transplantation therapies offer hope for currently untreatable retinal degenerations; however, preclinical progress has been largely confined to rodent models. Here, we describe an experimental platform for accelerating phot...
Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells [0.03%]
Mthfd2通过调节线粒体功能和DNA修复维持小鼠干细胞的多能性
Liang Yue,Yangli Pei,Liang Zhong et al.
Liang Yue et al.
The pluripotency of stem cells determines their developmental potential. While the pluripotency states of pluripotent stem cells are variable and interconvertible, the mechanisms underlying the acquisition and maintenance of pluripotency re...