Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons [0.03%]
PARKIN缺陷的人类多巴胺神经元中线粒体生物发生中的缺陷导致线粒体改变
Manoj Kumar,Jesús Acevedo-Cintrón,Aanishaa Jhaldiyal et al.
Manoj Kumar et al.
Mutations and loss of activity in PARKIN, an E3 ubiquitin ligase, play a role in the pathogenesis of Parkinson's disease (PD). PARKIN regulates many aspects of mitochondrial quality control including mitochondrial autophagy (mitophagy) and ...
"Reprogram Enablement" as an Assay for Identifying Early Oncogenic Pathways by Their Ability to Allow Neoplastic Cells to Reacquire an Epiblast State [0.03%]
"重新编程启用"作为检测早期致癌途径的试验，根据其允许新细胞重获上胚层状态的能力
Yanjun Kong,Ryan C Gimple,Rachael N McVicar et al.
Yanjun Kong et al.
One approach to understanding how tissue-specific cancers emerge is to determine the requirements for "reprograming" such neoplastic cells back to their developmentally normal primordial pre-malignant epiblast-like pluripotent state and the...
GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation [0.03%]
GATA6-AS1通过调节GATA6的表达来调控人类内胚层分化
Jie Yang,Pei Lu,Mao Li et al.
Jie Yang et al.
Transcriptome analysis has uncovered a series of long noncoding RNAs (lncRNAs) transcribed during cell differentiation, but how lncRNA is integrated with known transcriptional regulatory network is poorly understood. Here, we utilize human ...
Clonal Hematopoiesis of Indeterminate Potential as a Novel Risk Factor for Donor-Derived Leukemia [0.03%]
不确定潜能克隆性造血作为供者来源白血病的一个新风险因素
Sarah S Burns,Reuben Kapur
Sarah S Burns
Hematopoietic stem cell transplantation (HSCT) is a critical treatment modality for many hematological and non-hematological diseases that is being extended to treat older individuals. However, recent studies show that clonal hematopoiesis ...
Direct Comparison of Four Hematopoietic Differentiation Methods from Human Induced Pluripotent Stem Cells [0.03%]
人诱导多能干细胞向造血细胞分化四种方法的直接比较
Melinda L Tursky,To Ha Loi,Crisbel M Artuz et al.
Melinda L Tursky et al.
Induced pluripotent stem cells (iPSCs) are an invaluable resource for the study of human disease. However, there are no standardized methods for differentiation into hematopoietic cells, and there is a lack of robust, direct comparisons of ...
Comparative Study
Stem cell reports. 2020 Sep 8;15(3):735-748. DOI:10.1016/j.stemcr.2020.07.009 2020
A Semi-automated and Scalable 3D Spheroid Assay to Study Neuroblast Migration [0.03%]
用于研究神经元迁移的半自动且可扩展的3D球状体测定法
Martin Ducker,Valerie Millar,Daniel Ebner et al.
Martin Ducker et al.
The subventricular zone of the mammalian brain is the major source of adult born neurons. These neuroblasts normally migrate long distances to the olfactory bulbs but can be re-routed to locations of injury and promote neuroregeneration. Me...
Distinct Phases of Postnatal Skeletal Muscle Growth Govern the Progressive Establishment of Muscle Stem Cell Quiescence [0.03%]
产后骨骼肌生长的不同阶段决定肌肉干细胞静止状态的逐步建立
Francesca Gattazzo,Béatrice Laurent,Frédéric Relaix et al.
Francesca Gattazzo et al.
Muscle stem cells (or muscle satellite cells [MuSCs]) are required for postnatal growth. Yet, the detailed characterization of myogenic progression and establishment of quiescence during this process remains poorly documented. Here, we prov...
Jing Chen,Qiong Zhou,Man-Hua Liu et al.
Jing Chen et al.
FAM122A is a highly conserved housekeeping gene, but its physiological and pathophysiological roles remain greatly elusive. Based on the fact that FAM122A is highly expressed in human CD71+ early erythroid cells, herein we report that FAM12...
Two Functional Axes of Feedback-Enforced PRC2 Recruitment in Mouse Embryonic Stem Cells [0.03%]
小鼠胚胎干细胞中反馈诱导PRC2招募的两个功能轴
Matteo Perino,Guido van Mierlo,Chet Loh et al.
Matteo Perino et al.
Polycomb Repressive Complex 2 (PRC2) plays an essential role in gene repression during development, catalyzing H3 lysine 27 trimethylation (H3K27me3). MTF2 in the PRC2.1 sub-complex, and JARID2 in PRC2.2, are central in core PRC2 recruitmen...
Single-Cell Mechanical Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Testing and Pathophysiological Studies [0.03%]
人类多能干细胞衍生的心肌细胞的单细胞力学分析在药物检测和病理生理学研究中的应用
Nimer Ballan,Naim Shaheen,Gordon M Keller et al.
Nimer Ballan et al.
Current platforms for studying the mechanical properties of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) as single cells do not measure forces directly, require numerous assumptions, and cannot study cell mechanics at diffe...