Splicing Factor SRSF1 Is Essential for Satellite Cell Proliferation and Postnatal Maturation of Neuromuscular Junctions in Mice [0.03%]
剪接因子SRSF1对小鼠卫星细胞增殖和神经肌肉突触的产后成熟至关重要
Yuguo Liu,Yangjun Luo,Lei Shen et al.
Yuguo Liu et al.
Satellite cells are main muscle stem cells that could provide myonuclei for myofiber growth and synaptic-specific gene expression during the early postnatal development. Here, we observed that splicing factor SRSF1 is highly expressed in my...
Recapitulation of Neural Crest Specification and EMT via Induction from Neural Plate Border-like Cells [0.03%]
通过神经板边缘样细胞的诱导对神经嵴命中的规定性和上皮间充质转化进行整理
Gerson Shigeru Kobayashi,Camila Manso Musso,Danielle de Paula Moreira et al.
Gerson Shigeru Kobayashi et al.
Neural crest cells (NCCs) contribute to several tissues during embryonic development. NCC formation depends on activation of tightly regulated molecular programs at the neural plate border (NPB) region, which initiate NCC specification and ...
Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures [0.03%]
软矩阵通过抑制YAP / TAZ和抑制成纤维细胞特征促进心脏重编程
Shota Kurotsu,Taketaro Sadahiro,Ryo Fujita et al.
Shota Kurotsu et al.
Direct cardiac reprogramming holds great potential for regenerative medicine. However, it remains inefficient, and induced cardiomyocytes (iCMs) generated in vitro are less mature than those in vivo, suggesting that undefined extrinsic fact...
A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution [0.03%]
一个调节脂质代谢的代谢物改变造血干细胞/祖细胞行为并促进淋巴重建
Sonja Giger,Larisa V Kovtonyuk,Sebastian G Utz et al.
Sonja Giger et al.
Fatty acid β-oxidation (FAO), the breakdown of lipids, is a metabolic pathway used by various stem cells. FAO levels are generally high during quiescence and downregulated with proliferation. The endogenous metabolite malonyl-CoA modulates...
Retinoic Acid Accelerates the Specification of Enteric Neural Progenitors from In-Vitro-Derived Neural Crest [0.03%]
维甲酸能加速由体外培养的神经嵴分化出的肠神经前体细胞的特化过程
Thomas J R Frith,Antigoni Gogolou,James O S Hackland et al.
Thomas J R Frith et al.
The enteric nervous system (ENS) is derived primarily from the vagal neural crest, a migratory multipotent cell population emerging from the dorsal neural tube between somites 1 and 7. Defects in the development and function of the ENS caus...
β-Catenin and Associated Proteins Regulate Lineage Differentiation in Ground State Mouse Embryonic Stem Cells [0.03%]
β-连环蛋白及其相关蛋白质调控小鼠胚胎干细胞的谱系分化
Fang Tao,Jelly Soffers,Deqing Hu et al.
Fang Tao et al.
Mouse embryonic stem cells (ESCs) cultured in defined medium resemble the pre-implantation epiblast in the ground state, with full developmental capacity including the germline. β-Catenin is required to maintain ground state pluripotency i...
Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells [0.03%]
用于同种或异种移植正常细胞和恶性细胞的foxn1/Casper突变斑马鱼的建立
Peng Lv,Dongyuan Ma,Shuai Gao et al.
Peng Lv et al.
Cell transplantation into immunodeficient recipients is a widely used approach to study stem cell and cancer biology; however, studying cell states post transplantation in vivo is inconvenient in mammals. Here, we generated a foxn1/Casper m...
Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions [0.03%]
经典的Wnt信号通路通过β-连环蛋白/ TCF / LEF 功能抑制内源性分化从而控制mESC的自我更新
Francesco Aulicino,Elisa Pedone,Francesco Sottile et al.
Francesco Aulicino et al.
The Wnt/β-catenin signaling pathway is a key regulator of embryonic stem cell (ESC) self-renewal and differentiation. Constitutive activation of this pathway has been shown to increase mouse ESC (mESC) self-renewal and pluripotency gene ex...
Estrogen Receptor β Controls Muscle Growth and Regeneration in Young Female Mice [0.03%]
雌激素受体β控制年轻雌鼠的肌肉生长和再生
Daiki Seko,Ryo Fujita,Yuriko Kitajima et al.
Daiki Seko et al.
Estrogens are female sex hormones that are important for comprehensively maintaining muscle function, and an insufficiency affects muscle strength and regeneration in females. However, it is still unclear whether estrogen signaling is media...
Mutation-Specific Guide RNA for Compound Heterozygous Porphyria On-target Scarless Correction by CRISPR/Cas9 in Stem Cells [0.03%]
干细胞中CRISPR / Cas9对复合杂合卟啉症的特定位点无痕修复研究
Florence Prat,Jérôme Toutain,Julian Boutin et al.
Florence Prat et al.
CRISPR/Cas9 is a promising technology for gene correction. However, the edition is often biallelic, and uncontrolled small insertions and deletions (indels) concomitant to precise correction are created. Mutation-specific guide RNAs were re...