Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency [0.03%]
重新编程到多能性的过程中 euchromatic 组蛋白甲基转移酶活性依赖于特定的细胞环境
Simon E Vidal,Alexander Polyzos,Kaushiki Chatterjee et al.
Simon E Vidal et al.
Methylation of histone 3 at lysine 9 (H3K9) constitutes a roadblock for cellular reprogramming. Interference with methyltransferases or activation of demethylases by the cofactor ascorbic acid (AA) facilitates the derivation of induced plur...
Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells [0.03%]
人中胚层间充质干细胞在稳态、炎症条件下以及在SARS-CoV-2感染细胞的存在下对SARS-CoV-2感染具有抗性
Richard Schäfer,Gabriele Spohn,Marco Bechtel et al.
Richard Schäfer et al.
Previous studies reported on the safety and applicability of mesenchymal stem/stromal cells (MSCs) to ameliorate pulmonary inflammation in acute respiratory distress syndrome (ARDS). Thus, multiple clinical trials assessing the potential of...
Vast Self-Renewal Potential of Human AGM Region HSCs Dramatically Declines in the Umbilical Cord Blood [0.03%]
人胎肝区域的HSCs具有巨大的自我更新潜能，这一潜能在其进入脐带血后则会急剧降低
Andrejs Ivanovs,Stanislav Rybtsov,Richard A Anderson et al.
Andrejs Ivanovs et al.
Human hematopoietic stem cells (HSCs) emerge in the aorta-gonad-mesonephros (AGM) region during Carnegie stages (CS) 14-17. Although we previously reported that these HSCs can generate no less than 300 daughter HSCs, their actual number has...
Centrosome Reduction Promotes Terminal Differentiation of Human Cardiomyocytes [0.03%]
中心体减少促进人心肌细胞的终末分化
Dominic C H Ng,Dominic K Richards,Richard J Mills et al.
Dominic C H Ng et al.
Centrosome reduction and redistribution of pericentriolar material (PCM) coincides with cardiomyocyte transitions to a post-mitotic and matured state. However, it is unclear whether centrosome changes are a cause or consequence of terminal ...
Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A [0.03%]
人类脑器官揭示UBE3A早期时空动力学和药理反应
Dilara Sen,Alexis Voulgaropoulos,Zuzana Drobna et al.
Dilara Sen et al.
Angelman syndrome is a complex neurodevelopmental disorder characterized by delayed development, intellectual disability, speech impairment, and ataxia. It results from the loss of UBE3A protein, an E3 ubiquitin ligase, in neurons of the br...
FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair [0.03%]
periosteum细胞中的FGFR3导致骨修复过程中软骨向骨的转化
Anais Julien,Simon Perrin,Oriane Duchamp de Lageneste et al.
Anais Julien et al.
Most organs and tissues in the body, including bone, can repair after an injury due to the activation of endogenous adult stem/progenitor cells to replace the damaged tissue. Inherent dysfunctions of the endogenous stem/progenitor cells in ...
Martin Pera
Martin Pera
Androgen Maintains Intestinal Homeostasis by Inhibiting BMP Signaling via Intestinal Stromal Cells [0.03%]
雄性激素通过肠道基质细胞抑制BMP信号来维持肠道稳态
Xin Yu,Shiguang Li,Yiming Xu et al.
Xin Yu et al.
Research shows a higher incidence of colorectal cancer in men. However, the molecular mechanisms for this gender disparity remain unknown. We report the roles of androgen in proliferation and differentiation of intestinal stem cells via tar...
Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells [0.03%]
受损肌纤维来源的代谢酶充当肌肉卫星细胞激活剂
Yoshifumi Tsuchiya,Yasuo Kitajima,Hiroshi Masumoto et al.
Yoshifumi Tsuchiya et al.
Muscle satellite cells are normally quiescent but are rapidly activated following muscle damage. Here, we investigated whether damaged myofibers influence the activation of satellite cells. Our findings revealed that satellite cells are dir...
A p53-Dependent Checkpoint Induced upon DNA Damage Alters Cell Fate during hiPSC Differentiation [0.03%]
DNA损伤引起的一种p53依赖的检测点在hiPSC分化过程中改变了细胞命运
Cara B Eldridge,Finian J Allen,Alastair Crisp et al.
Cara B Eldridge et al.
The ability of human induced pluripotent stem cells (hiPSCs) to differentiate in vitro to each of the three germ layer lineages has made them an important model of early human development and a tool for tissue engineering. However, the fact...