Embryo size regulates the timing and mechanism of pluripotent tissue morphogenesis [0.03%]
胚胎大小调节多能性组织形态发生的时机和机制
Lorenzo C Orietti,Viviane Souza Rosa,Francesco Antonica et al.
Lorenzo C Orietti et al.
Mammalian embryogenesis is a paradigm of regulative development as mouse embryos show plasticity in the regulation of cell fate, cell number, and tissue morphogenesis. However, the mechanisms behind embryo plasticity remain largely unknown....
Weikun Xia,Wei Xie
Weikun Xia
Upon fertilization, terminally differentiated gametes are transformed to a totipotent zygote, which gives rise to an embryo. How parental epigenetic memories are inherited and reprogrammed to accommodate parental-to-zygotic transition remai...
Andrew T Crane,Francis X Shen,Jennifer L Brown et al.
Andrew T Crane et al.
We report findings from a new survey of US public attitudes toward human-animal chimeric embryo (HACE) research, designed to compare with recently reported Japanese survey data. We find that 59% of the US public can personally accept the pr...
Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization [0.03%]
胚胎干细胞中核仁的调控及作用：从核糖体生物发生到基因组组织
Shivani Gupta,Raffaella Santoro
Shivani Gupta
The nucleolus is the largest compartment of the eukaryotic cell's nucleus. It acts as a ribosome factory, thereby sustaining the translation machinery. The nucleolus is also the subnuclear compartment with the highest transcriptional activi...
Anteroposterior Wnt-RA Gradient Defines Adhesion and Migration Properties of Neural Progenitors in Developing Spinal Cord [0.03%]
前后Wnt-RA梯度定义了发育脊髓中神经前体细胞的粘附和迁移特性
Mohammed R Shaker,Ju-Hyun Lee,Si-Hyung Park et al.
Mohammed R Shaker et al.
Mammalian embryos exhibit a transition from head morphogenesis to trunk elongation to meet the demand of axial elongation. The caudal neural tube (NT) is formed with neural progenitors (NPCs) derived from neuromesodermal progenitors localiz...
Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection [0.03%]
通过基因组编辑和同胞选择精确纠正来自房颤患者的hiPSC中的杂合SHOX2突变
Simon Alexander Sumer,Sandra Hoffmann,Svenja Laue et al.
Simon Alexander Sumer et al.
Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillati...
Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons [0.03%]
人胎和干细胞来源的胶质前体细胞直接重编程为中脑多巴胺能神经元
Sara Nolbrant,Jessica Giacomoni,Deirdre B Hoban et al.
Sara Nolbrant et al.
Human glial progenitor cells (hGPCs) are promising cellular substrates to explore for the in situ production of new neurons for brain repair. Proof of concept for direct neuronal reprogramming of glial progenitors has been obtained in mouse...
Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development [0.03%]
脑类器官的电生理成熟与动态形态和细胞发育相关
Summer R Fair,Dominic Julian,Annalisa M Hartlaub et al.
Summer R Fair et al.
Cerebral organoids (COs) are rapidly accelerating the rate of translational neuroscience based on their potential to model complex features of the developing human brain. Several studies have examined the electrophysiological and neural net...
Long Non-coding RNA T-UCstem1 Controls Progenitor Proliferation and Neurogenesis in the Postnatal Mouse Olfactory Bulb through Interaction with miR-9 [0.03%]
长非编码RNA T-UCstem1通过与miR-9的相互作用调控后代小鼠嗅球祖细胞增殖和神经发生
Emilia Pascale,Christophe Beclin,Alessandro Fiorenzano et al.
Emilia Pascale et al.
Neural stem cell populations generate a wide spectrum of neuronal and glial cell types in a highly ordered fashion. MicroRNAs are essential regulators of this process. T-UCstem1 is a long non-coding RNA containing an ultraconserved element,...
Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage [0.03%]
鉴定Qk作为前体细胞标记物在神经干细胞向胶质细胞命运转化中的作用
Akihide Takeuchi,Yuji Takahashi,Kei Iida et al.
Akihide Takeuchi et al.
During brain development, neural stem cells (NSCs) initially produce neurons and change their fate to generate glias. While the regulation of neurogenesis is well characterized, specific markers for glial precursor cells (GPCs) and the mast...