Ilana Carmel-Gross,Etgar Levy,Leah Armon et al.
Ilana Carmel-Gross et al.
Epigenetic regulation by the SWI/SNF complex is essential for normal self-renewal capacity and pluripotency of human pluripotent stem cells (hPSCs). It has been shown that different subunits of the complex have a distinct role in this regul...
Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells [0.03%]
瘦素受体信号调节多能干细胞中的蛋白质合成途径和神经元分化
Manoj K Gupta,Heidrun Vethe,Samir Softic et al.
Manoj K Gupta et al.
The role of leptin receptor (OB-R) signaling in linking pluripotency with growth and development and the consequences of dysfunctional leptin signaling on progression of metabolic disease is poorly understood. Using a global unbiased proteo...
Relative Levels of Gli1 and Gli2 Determine the Response of Ventral Neural Stem Cells to Demyelination [0.03%]
Gli1和Gli2的相对水平决定背根神经节神经干细胞对脱髓鞘的反应
Daniel Z Radecki,Heather M Messling,James R Haggerty-Skeans et al.
Daniel Z Radecki et al.
Enhancing repair of myelin is an important therapeutic goal in many neurological disorders characterized by demyelination. In the healthy adult brain, ventral neural stem cells (vNSCs) in the subventricular zone, marked by GLI1 expression, ...
Quick Commitment and Efficient Reprogramming Route of Direct Induction of Retinal Ganglion Cell-like Neurons [0.03%]
快速诱导生成视网膜神经节细胞样神经元及其高效重编程路径
Jing Wang,Qinghai He,Ke Zhang et al.
Jing Wang et al.
Direct reprogramming has been widely explored to generate various types of neurons for neurobiological research and translational medicine applications, but there is still no efficient reprogramming method to generate retinal ganglion cell ...
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice [0.03%]
体内重编程改善小鼠齿状回细胞的衰老特征并提高记忆力
Alberto Rodríguez-Matellán,Noelia Alcazar,Félix Hernández et al.
Alberto Rodríguez-Matellán et al.
Post-translational epigenetic modifications take place in mouse neurons of the dentate gyrus (DG) with age. Here, we report that age-dependent reduction in H3K9 trimethylation (H3K9me3) is prevented by cyclic induction of the Yamanaka facto...
Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells [0.03%]
单细胞RNA序列揭示CD9是来自人类多能干细胞的葡萄糖响应性胰岛素样细胞的负向标记物
Xisheng Li,Kevin Y Yang,Vicken W Chan et al.
Xisheng Li et al.
To date, it remains unclear if there are specific cell-surface markers for purifying glucose-responsive pancreatic β-like cells derived from human pluripotent stem cells (hPSCs). In searching for this, we generated an efficient protocol fo...
Basal-like Progenitor Cells: A Review of Dysplastic Alveolar Regeneration and Remodeling in Lung Repair [0.03%]
基底样祖细胞：肺修复过程中异常肺泡再生和重塑的综述
Maria Fernanda de Mello Costa,Aaron I Weiner,Andrew E Vaughan
Maria Fernanda de Mello Costa
Despite the central importance of the respiratory system, the exact mechanisms governing lung repair after severe injury remain unclear. The notion that alveolar type 2 cells (AT2s) self-renew and differentiate into alveolar type 1 cells (A...
Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression [0.03%]
活体影像揭示小脑神经干细胞的动态及VNUT在谱系进展中的作用
Lucía Paniagua-Herranz,Aida Menéndez-Méndez,Rosa Gómez-Villafuertes et al.
Lucía Paniagua-Herranz et al.
Little is known about the intrinsic specification of postnatal cerebellar neural stem cells (NSCs) and to what extent they depend on information from their local niche. Here, we have used an adapted cell preparation of isolated postnatal NS...
Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format [0.03%]
用于工程心脏组织药筛的十种控制hPSC系的比较研究
Ingra Mannhardt,Umber Saleem,Diogo Mosqueira et al.
Ingra Mannhardt et al.
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are commercially available, and cardiac differentiation established routine. Systematic evaluation of several control hiPSC-CM is lacking. We investigated 10 different co...
Comparative Study
Stem cell reports. 2020 Oct 13;15(4):983-998. DOI:10.1016/j.stemcr.2020.09.002 2020
WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche [0.03%]
维持精原干细胞生态位需要支持细胞中的WTAP功能
Gong-Xue Jia,Zhen Lin,Rong-Ge Yan et al.
Gong-Xue Jia et al.
Sertoli cells are the major component of the spermatogonial stem cell (SSC) niche; however, regulatory mechanisms in Sertoli cells that dictate SSC fate decisions remain largely unknown. Here we revealed features of the N6-methyladenosine (...