The miR-199a/214 Cluster Controls Nephrogenesis and Vascularization in a Human Embryonic Stem Cell Model [0.03%]
miR-199a/214簇通过人类胚胎干细胞模型控制肾生成和血管化
Ioannis Bantounas,Filipa M Lopes,Kirsty M Rooney et al.
Ioannis Bantounas et al.
MicroRNAs (miRNAs) are gene expression regulators and they have been implicated in acquired kidney diseases and in renal development, mostly through animal studies. We hypothesized that the miR-199a/214 cluster regulates human kidney develo...
Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart Fails [0.03%]
利用人类多能干细胞进行心血管细胞的COVID-19研究：为什么心脏会衰竭
Loukia Yiangou,Richard P Davis,Christine L Mummery
Loukia Yiangou
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the coronavirus disease (COVID-19) outbreak that became a pandemic in 2020, causing more than 30 million infections and 1 million deaths to date. As the scientific comm...
MeCP2 and Major Satellite Forward RNA Cooperate for Pericentric Heterochromatin Organization [0.03%]
MeCP2和主要卫星前向RNA合作以实现着丝粒异染色质的组织
Salvatore Fioriniello,Eva Csukonyi,Domenico Marano et al.
Salvatore Fioriniello et al.
Methyl-CpG binding protein 2 (MeCP2) has historically been linked to heterochromatin organization, and in mouse cells it accumulates at pericentric heterochromatin (PCH), closely following major satellite (MajSat) DNA distribution. However,...
Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and β-Catenin [0.03%]
组蛋白甲基转移酶SET通过与p53和β-catenin的相互作用调节胚胎干细胞分化
Arigela Harikumar,Patrick S L Lim,Malka Nissim-Rafinia et al.
Arigela Harikumar et al.
The multifunctional histone chaperone, SET, is essential for embryonic development in the mouse. Previously, we identified SET as a factor that is rapidly downregulated during embryonic stem cell (ESC) differentiation, suggesting a possible...
TINC- A Method to Dissect Regulatory Complexes at Single-Locus Resolution- Reveals an Extensive Protein Complex at the Nanog Promoter [0.03%]
基于单基因分辨率剖析调控复合体的方法-TINC-揭示了NANOG启动子处的一个大型蛋白质复合体
Anja S Knaupp,Monika Mohenska,Michael R Larcombe et al.
Anja S Knaupp et al.
Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory elements (REs) to control gene expression. Advances in epigenome profiling techniques have significantly increased our understanding of cel...
Histone Modifications in Stem Cell Development and Their Clinical Implications [0.03%]
组蛋白修饰在干细胞发育及其临床意义中的作用
Moritz Völker-Albert,Abel Bronkhorst,Stefan Holdenrieder et al.
Moritz Völker-Albert et al.
Human stem cells bear a great potential for multiple therapeutic applications but at the same time constitute a major threat to human health in the form of cancer stem cells. The molecular processes that govern stem cell maintenance or diff...
Eran Meshorer,Kathrin Plath
Eran Meshorer
Here we outline the contents of Stem Cell Reports' first special issue, on chromatin and nuclear architecture in stem cells. It features both reviews and original research articles, covering emerging topics in nuclear architecture including...
Genomic Safe Harbor Expression of PAX7 for the Generation of Engraftable Myogenic Progenitors [0.03%]
PAX7安全港表达生成可植入肌原细胞
Hyunkee Kim,Sridhar Selvaraj,James Kiley et al.
Hyunkee Kim et al.
Inducible expression of PAX7 in differentiating pluripotent stem cells (PSCs) allows massively scalable generation of human myogenic progenitors, which upon transplantation into dystrophic muscles give rise to donor-derived myofibers and sa...
Peter Lansdorp
Peter Lansdorp
We are pleased to introduce a new feature in this issue of Stem Cell Reports in which we invite an author to share a personal narrative about his or her paper, also published in this edition. In this Q&A format, the author shares perspectiv...