Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells [0.03%]
人和猕猴多能干细胞低嵌合 competence 与细胞凋亡、G1 期阻滞及过早分化相关
Irène Aksoy,Cloé Rognard,Anaïs Moulin et al.
Irène Aksoy et al.
After reprogramming to naive pluripotency, human pluripotent stem cells (PSCs) still exhibit very low ability to make interspecies chimeras. Whether this is because they are inherently devoid of the attributes of chimeric competency or beca...
Ablating Adult Neural Stem Cells Improves Synaptic and Cognitive Functions in Alzheimer Models [0.03%]
在阿尔茨海默病模型中消融成人神经干细胞可改善突触和认知功能
Xiaoqin Zhang,Yufei Mei,Yang He et al.
Xiaoqin Zhang et al.
Adult neurogenesis is impaired in the hippocampus of patients with Alzheimer disease (AD) as well as AD models. However, it is far from clear how modulating adult neurogenesis affects AD neuropathology. We confirm that adult hippocampal neu...
Vivian W Gu,Edward Cho,Dakota T Thompson et al.
Vivian W Gu et al.
Mammary gland ductal morphogenesis depends on the differentiation of mammary stem cells (MaSCs) into basal and luminal lineages. The AP-2γ transcription factor, encoded by Tfap2c, has a central role in mammary gland development but its eff...
Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells [0.03%]
Bach2缺陷通过加速肠道干细胞中的DNA修复促进肠上皮再生
Yuanchuang Li,Xinxin Rao,Peiyuan Tang et al.
Yuanchuang Li et al.
Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury, although the repair mechanisms are unclear. Here, we found that Bach2 deficiency promotes intestinal epithelial cell proliferation durin...
Azimeh Akhlaghpour,Adeleh Taei,Seyyed Abolghasem Ghadami et al.
Azimeh Akhlaghpour et al.
Human pluripotent stem cells (hPSCs) are commonly kept in a primed state but also able to acquire a more immature naive state under specific conditions in vitro. Acquisition of naive state changes several properties of hPSCs and might affec...
Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors [0.03%]
五羟色胺受体6固有活性调节人脑类器官形成及类似抑郁的行为
Qinying Wang,Xiaoxu Dong,Tingting Hu et al.
Qinying Wang et al.
Serotonin receptor 6 (5-HT6R), a typical G protein-coupled receptor (GPCR) mainly expressed in the neurogenic area with constitutive activity, is of particular interest as a promising target for emotional impairment. Here, we found that 5-H...
Effects of Cryopreservation on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Assessing Drug Safety Response Profiles [0.03%]
cryopreservation对人诱导多能干细胞源性心肌细胞药物安全评价作用的影响profiling评估的作用影响
Joe Z Zhang,Nadjet Belbachir,Tiejun Zhang et al.
Joe Z Zhang et al.
Burgeoning applications of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in disease modeling, regenerative medicine, and drug screening have broadened the usage of hiPSC-CMs and entailed their long-term storage. Cry...
Jeroen M Stein,Christine L Mummery,Milena Bellin
Jeroen M Stein
Human heart (patho)physiology is now widely studied using human pluripotent stem cells, but the immaturity of derivative cardiomyocytes has largely limited disease modeling to conditions associated with mutations in cardiac ion channel gene...
Extraembryonic Endoderm (XEN) Cells Capable of Contributing to Embryonic Chimeras Established from Pig Embryos [0.03%]
源自猪胚胎的能够嵌合到胚胎中的额外胚内胚层(XEN)细胞
Chi-Hun Park,Young-Hee Jeoung,Kyung-Jun Uh et al.
Chi-Hun Park et al.
Most of our current knowledge regarding early lineage specification and embryo-derived stem cells comes from studies in rodent models. However, key gaps remain in our understanding of these developmental processes from nonrodent species. He...
A Scalable Suspension Platform for Generating High-Density Cultures of Universal Red Blood Cells from Human Induced Pluripotent Stem Cells [0.03%]
一种可扩展的悬架平台 用于从人类诱导多能干细胞生成高密度的通用红血细胞文化
Jaichandran Sivalingam,Yu SuE,Zhong Ri Lim et al.
Jaichandran Sivalingam et al.
Universal red blood cells (RBCs) differentiated from O-negative human induced pluripotent stem cells (hiPSCs) could find applications in transfusion medicine. Given that each transfusion unit of blood requires 2 trillion RBCs, efficient bio...