Haiyun Wang,Yusha Li,Chunkou Yin et al.
Haiyun Wang et al.
Nuclear receptors (NRs) are ligand-regulated transcription factors whose domains and dosage modulate gene networks. We systematically profiled 49 murine NRs in OKS (OCT4/KLF4/SOX2) reprogramming of mouse fibroblasts and identified the ROR s...
Hematopoietic stem and progenitor cell hierarchy is established by thrombopoietin-driven neonatal hematopoiesis [0.03%]
血小板生成素驱动的生后造血建立了造血干细胞层级体系
Makiko Mochizuki-Kashio,Ayano Yahagi,Tomomasa Yokomizo et al.
Makiko Mochizuki-Kashio et al.
The cytokine thrombopoietin (THPO) promotes both self-renewal and cell cycle quiescence of adult bone marrow (BM) hematopoietic stem cells (HSCs). It remains unclear how THPO differentially regulates HSC expansion versus quiescence and whet...
3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease [0.03%]
基于同基因hiPSC来源的VSMC的血管芯片揭示了脑小血管病中NOTCH3驱动的改变
Marc Vila Cuenca,Theano Tsikari,Minne N Cerfontaine et al.
Marc Vila Cuenca et al.
cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary brain small vessel disease caused by pathogenic variants in the NOTCH3 gene, leading to NOTCH3 protein accumulation and deg...
Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells [0.03%]
利用人类多能干细胞剖析微胶质细胞在神经退行性疾病病理生理学中的作用
Dayoung Kim,Takayuki Kondo,Haruhisa Inoue
Dayoung Kim
Neurodegenerative diseases are characterized by progressive neuronal dysfunction and loss. Microglia, the brain's resident macrophages, are key contributors to disease pathogenesis, with many genetic risk variants enriched in microglia-spec...
Roger A Barker,Agnete Kirkeby
Roger A Barker
The regenerative role of neural crest stem cells in physical stimuli-enhanced peripheral nerve repair [0.03%]
物理刺激促进外周神经再生中神经嵴干细胞的再生作用
Youyi Tai,Lu Jin,Thamidul Islam Tonmoy et al.
Youyi Tai et al.
Neural crest stem cells (NCSCs), capable of differentiating into neurons and Schwann cells, are essential for peripheral nerve regeneration. This study investigates the role of endogenous NCSC-like cells in mechano-electrical stimulation (M...
Deuterosomal cells are the responsible lineage for multiciliogenesis in human airway differentiation [0.03%]
人呼吸道分化过程中多纤毛发生由Deuterosomal细胞负责
Haruka Yamaki,Satoshi Konishi,Koji Tamai et al.
Haruka Yamaki et al.
Multiciliated cells (MCCs) are pivotal in airway defense via their motile cilia to eliminate inhaled pathogens and particles. Genetic variants in primary ciliary dyskinesia (PCD) disrupt ciliary function, resulting in chronic respiratory in...
Toward standardized iPSC testing: Insights from a multi-year international Quality Assessment Round [0.03%]
迈向标准化的 iPSC 检测：多年国际质量评估调查的启示
Alice Hägg,Rachel Wood,Ayako L Mochizuki et al.
Alice Hägg et al.
Despite rapid clinical translation, induced pluripotent stem cell (iPSC)-derived therapies face limited global adoption. Harmonized quality control (QC) remains absent, with even fundamental parameters evaluated inconsistently across labora...
Diversity-in-a-dish: A practical framework for hiPSC model development [0.03%]
盘中多样性的框架：一种hiPSC模型开发实用方法
Jesse Weidema,Hanna Lammertse,Martine de Vries et al.
Jesse Weidema et al.
Human induced pluripotent stem cell (hiPSC) models inherit donor-specific variation, affecting experimental outcomes and generalizability. While diversity is widely discussed in biomedical research and extensively theorized in genomics, com...
Anesthetic-induced neurodevelopmental changes with region-specific responses to propofol in forebrain organoids [0.03%]
丙泊酚诱导人脑类器官皮层区域特异性的神经发育改变
Hong-Qing She,Chang-Le Fang,Qi-Jun Li et al.
Hong-Qing She et al.
Propofol, a common anesthetic, has unclear effects on fetal brain development. While previous studies in animal models and 2D culture systems have reported neurotoxic effects, few have addressed the region-specific vulnerability of the deve...