Alejandro De Los Angeles
Alejandro De Los Angeles
Naive human pluripotent stem cells (hPSCs) closely mirror the pre-implantation epiblast but risk imprint erosion under strong MEK/ERK inhibition, jeopardizing disease modeling and regenerative applications. In Stem Cell Reports, Fischer et ...
Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation [0.03%]
女性hiPSCs中X染色体失活侵蚀引起的基因重新激活是可预测的但具有差异性并持续到分化过程中
Ana Cláudia Raposo,Paulo Caldas,Joana Jeremias et al.
Ana Cláudia Raposo et al.
Female human induced pluripotent stem cells frequently undergo X-chromosome inactivation (XCI) erosion, marked by X-inactive specific transcript (XIST) RNA loss and partial reactivation of the inactive X (Xi). This overlooked phenomenon lim...
Competing dynamic gene regulatory networks involved in fibroblast reprogramming to hematopoietic progenitor cells [0.03%]
竞争的动态基因调控网络参与成纤维细胞重编程为造血祖细胞的过程中
Samiyah Shafiq,Kiyofumi Hamashima,Laura A Guest et al.
Samiyah Shafiq et al.
Direct reprogramming of somatic cells offers a potentially safer therapeutic approach to generate patient-specific hematopoietic cells. However, this strategy is limited by stochasticity of reprogramming. Investigating the gene regulatory n...
Large-scale analysis of loss of chromosome Y in human pluripotent stem cells: Implications for Turner syndrome and ribosomopathies [0.03%]
人类多能干细胞中Y染色体丢失的大规模分析：对特纳综合症和核糖体病的启示
Roni Sarel-Gallily,Keith M Gunapala,Nissim Benvenisty
Roni Sarel-Gallily
Loss of chromosome Y (LOY) occurs in aging and cancers, but its extent and implications in human embryonic stem cells (hESCs) have not been studied. Here, we analyzed over 2,650 RNA sequencing (RNA-seq) samples from hESCs and their differen...
ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons [0.03%]
与ALS相关的p97 R155H突变会破坏由iPSC分化而来的运动神经元中的溶酶体自噬过程
Jacob A Klickstein,Michelle A Johnson,Pantelis Antonoudiou et al.
Jacob A Klickstein et al.
Published Erratum
Stem cell reports. 2025 Mar 28:102478. DOI:10.1016/j.stemcr.2025.102478 2025
Human cone photoreceptor transplantation stimulates remodeling and restores function in AIPL1 model of end-stage Leber congenital amaurosis [0.03%]
人类锥体光感受器移植刺激AIPL1型终末期勒伯先天性黑矇的重建和功能恢复
Christopher A Procyk,Anna Melati,Joana Ribeiro et al.
Christopher A Procyk et al.
Photoreceptor degeneration is a leading cause of untreatable sight loss. Previously, we showed that human pluripotent stem cell-derived cone photoreceptors (hCones) can rescue retinal function in the Rd1 mouse model of rod-cone dystrophy. H...
Dissecting cardiovascular disease-associated noncoding genetic variants using human iPSC models [0.03%]
使用人类iPSC模型解析与心血管疾病相关的非编码遗传变异
Saif F Dababneh,Hosna Babini,Verónica Jiménez-Sábado et al.
Saif F Dababneh et al.
Advancements in genomics have revealed hundreds of loci associated with cardiovascular diseases, highlighting the role genetic variants play in disease pathogenesis. Notably, most variants lie within noncoding genomic regions that modulate ...
Long-term preservation of muscle function and structure by repeated administration of cardiosphere-derived cells in mdx mice [0.03%]
通过重复给予心球衍生细胞来长期保持mdx小鼠的肌肉功能和结构
Russell G Rogers,Jack Antich,Mario Fournier et al.
Russell G Rogers et al.
Duchenne muscular dystrophy (DMD) is a progressive myodegenerative disease that leads to severe muscle weakness and premature death. Mouse cardiosphere-derived cells (mCDCs) and extracellular vesicles (EVs) secreted by human cardiosphere-de...
Stefania Apostolou,Vanessa Donega
Stefania Apostolou
Neural stem cells (NSCs) of the subventricular zone (SVZ) could be a potential source for brain repair. These are heterogeneous cells with distinct activation states. To identify NSCs in the SVZ, different markers are used, including Gfap, ...
The lung microvasculature promotes alveolar type 2 cell differentiation via secreted SPARCL1 [0.03%]
肺微血管通过分泌SPARCL1促进II型肺泡细胞的分化
Paolo Panza,Hyun-Taek Kim,Till Lautenschläger et al.
Paolo Panza et al.
Lung endothelial cells (ECs) and pericytes are closely juxtaposed with the respiratory epithelium before birth and thus may have instructive roles during development. To test this hypothesis, we screened EC-secreted proteins for their abili...