Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression [0.03%]
免疫抑制下将人视网膜色素上皮干细胞来源的视网膜色素上皮单层移植到非人灵长类动物中
Zengping Liu,Bhav Harshad Parikh,Queenie Shu Woon Tan et al.
Zengping Liu et al.
Recent trials of retinal pigment epithelium (RPE) transplantation for the treatment of disorders such as age-related macular degeneration have been promising. However, limitations of existing strategies include the uncertain survival of RPE...
Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation [0.03%]
携带患者特异性突变的干细胞分化肝细胞的胆汁酸转运和合成模型构建
Hisamitsu Hayashi,Shuhei Osaka,Kokoro Sakabe et al.
Hisamitsu Hayashi et al.
The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes. Impaired transcellular transport of bile acids in hepatocytes with mutations in BSEP causes cholestasis. Compensatory mechanisms to regulate the i...
Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone [0.03%]
甲状腺转运蛋白MCT8和OATP1C1的缺失会损害成年小鼠脑侧脑室区神经干细胞的命运决定
Cristina Luongo,Lucile Butruille,Anthony Sébillot et al.
Cristina Luongo et al.
Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population is unknown, although TH availability determines proliferation and neuronal versus glial progenitor determination ...
Challenges for Computational Stem Cell Biology: A Discussion for the Field [0.03%]
计算干细胞生物学的挑战：领域内的讨论
Owen Rackham,Patrick Cahan,Nancy Mah et al.
Owen Rackham et al.
The first meetup for Computational Stem Cell Biologists was held at the 2020 annual meeting of the International Society for Stem Cell Research. The discussions highlighted opportunities and barriers to computational stem cell research that...
A Genetic Screen Identifies Etl4-Deficiency Capable of Stabilizing the Haploidy in Embryonic Stem Cells [0.03%]
遗传筛选鉴定出Etl4缺失能在胚胎干细胞中稳定单倍体状态
Guozhong Zhang,Xiaowen Li,Yi Sun et al.
Guozhong Zhang et al.
Mammalian haploid embryonic stem cells (haESCs) hold great promise for functional genetic studies and forward screening. However, all established haploid cells are prone to spontaneous diploidization during long-term culture, rendering appl...
Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors [0.03%]
旋转壁血管生物反应器加速和改善多能干细胞向视网膜类器官的分化
Tyler J DiStefano,Holly Yu Chen,Christopher Panebianco et al.
Tyler J DiStefano et al.
Published Erratum
Stem cell reports. 2021 Jan 12;16(1):224. DOI:10.1016/j.stemcr.2020.12.006 2021
Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis [0.03%]
造血干细胞和红系祖细胞对核糖体生物合成受损的敏感性随蛋白质合成发育阶段特异性变化而不同地改变
Jeffrey A Magee,Robert A J Signer
Jeffrey A Magee
Adult hematopoietic stem cell (HSC) self-renewal requires precise control of protein synthesis, but fetal and adult HSCs have distinct self-renewal mechanisms and lineage outputs. This raises the question of whether protein synthesis rates ...
Mentorship in Science: Response to AlShebli et al., Nature Communications 2020 [0.03%]
对AlShebli等《自然-通讯》2020年文章的评论：科学领域的指导性关系
Christine Mummery,Melissa Little,Haifan Lin et al.
Christine Mummery et al.
Associate Editor Q&A: Jun Takahashi and Christine Wells [0.03%]
编辑室访谈： Takahashi Jun与Christine Wells
Two new associate editors, Jun Takahashi, M.D., Ph.D., and Christine Wells, Ph.D., have recently joined the editorial team at Stem Cell Reports, the ISSCR's open access journal. Jun Takahashi is a physician-scientist at the Center for iPS C...
Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells [0.03%]
内界膜在移植的人诱导多能干细胞源性视网膜神经节细胞结构整合和拓扑间距作用中的作用研究
Kevin Y Zhang,Caitlyn Tuffy,Joseph L Mertz et al.
Kevin Y Zhang et al.
Retinal ganglion cell (RGC) replacement holds potential for restoring vision lost to optic neuropathy. Transplanted RGCs must undergo neuroretinal integration to receive afferent visual signals for processing and efferent transmission. To d...